Novel insights into the Leishmania infantum transcriptome diversity of protein-coding and non-coding sequences in both stages of parasite development using nanopore direct RNA sequencing

Novel insights into the Leishmania infantum transcriptome diversity of protein-coding and non-coding sequences in both stages of parasite development using nanopore direct RNA sequencing

Abstract Background Leishmania relies on posttranscriptional control to regulate gene expression. Protein-coding genes are synthesised as polycistronic precursors that are processed into individual mRNAs by trans-splicing adding the spliced leader (SL) RNA to the 5’-end and 3’ cleavage-polyadenylati...

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Bibliographic Details
Main Authors: Jean-Guillaume Emond-Rheault, Gabriel Reis Ferreira, Camille Lavoie-Ouellet, Martin A. Smith, Barbara Papadopoulou
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Genomics
Subjects:
Leishmania infantum
Nanopore direct RNA sequencing
Illumina RNA-Seq
trans-splicing
Polyadenylation
Alternative RNA processing
Online Access:https://doi.org/10.1186/s12864-025-11767-8
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