Lipoprotein(a) and Atherosclerotic Cardiovascular Diseases: Evidence from Chinese Population
Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Multiple factors are involved in CVD, and emerging data indicate that lipoprotein(a) (Lp(a)) may be associated with atherosclerotic cardiovascular disease (ASCVD) independent of other traditional risk factors. Lp(a) has been i...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2023-03-01
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| Series: | Cardiology Discovery |
| Online Access: | http://journals.lww.com/10.1097/CD9.0000000000000059 |
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| author | Jianjun Li |
| author_facet | Jianjun Li |
| author_sort | Jianjun Li |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Multiple factors are involved in CVD, and emerging data indicate that lipoprotein(a) (Lp(a)) may be associated with atherosclerotic cardiovascular disease (ASCVD) independent of other traditional risk factors. Lp(a) has been identified as a novel therapeutic target. Previous studies on the influence of Lp(a) in CVD have mainly used in western populations. In this review, the association of plasma Lp(a) concentration with ASCVD was summarized, with regards to epidemiological, population-based observational, and pathological studies in Chinese populations. Lp(a) mutations and copy number variations in Chinese populations are also explored. Finally, the impact of plasma Lp(a) levels on patients with type 2 diabetes mellitus, cancer, and familial hypercholesterolemia are discussed. |
| format | Article |
| id | doaj-art-0c44d3a271ea4d8aa3baacd8d9ccc81d |
| institution | OA Journals |
| issn | 2096-952X 2693-8499 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Cardiology Discovery |
| spelling | doaj-art-0c44d3a271ea4d8aa3baacd8d9ccc81d2025-08-20T02:26:09ZengWolters Kluwer Health/LWWCardiology Discovery2096-952X2693-84992023-03-0131404710.1097/CD9.0000000000000059202303000-00006Lipoprotein(a) and Atherosclerotic Cardiovascular Diseases: Evidence from Chinese PopulationJianjun Li0Cardiometabolic Center, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China.Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Multiple factors are involved in CVD, and emerging data indicate that lipoprotein(a) (Lp(a)) may be associated with atherosclerotic cardiovascular disease (ASCVD) independent of other traditional risk factors. Lp(a) has been identified as a novel therapeutic target. Previous studies on the influence of Lp(a) in CVD have mainly used in western populations. In this review, the association of plasma Lp(a) concentration with ASCVD was summarized, with regards to epidemiological, population-based observational, and pathological studies in Chinese populations. Lp(a) mutations and copy number variations in Chinese populations are also explored. Finally, the impact of plasma Lp(a) levels on patients with type 2 diabetes mellitus, cancer, and familial hypercholesterolemia are discussed.http://journals.lww.com/10.1097/CD9.0000000000000059 |
| spellingShingle | Jianjun Li Lipoprotein(a) and Atherosclerotic Cardiovascular Diseases: Evidence from Chinese Population Cardiology Discovery |
| title | Lipoprotein(a) and Atherosclerotic Cardiovascular Diseases: Evidence from Chinese Population |
| title_full | Lipoprotein(a) and Atherosclerotic Cardiovascular Diseases: Evidence from Chinese Population |
| title_fullStr | Lipoprotein(a) and Atherosclerotic Cardiovascular Diseases: Evidence from Chinese Population |
| title_full_unstemmed | Lipoprotein(a) and Atherosclerotic Cardiovascular Diseases: Evidence from Chinese Population |
| title_short | Lipoprotein(a) and Atherosclerotic Cardiovascular Diseases: Evidence from Chinese Population |
| title_sort | lipoprotein a and atherosclerotic cardiovascular diseases evidence from chinese population |
| url | http://journals.lww.com/10.1097/CD9.0000000000000059 |
| work_keys_str_mv | AT jianjunli lipoproteinaandatheroscleroticcardiovasculardiseasesevidencefromchinesepopulation |