Risk Factors and Awareness of Bone Fragility in Inflammatory Bowel Disease in Taiwan: A Cross-Sectional Study
<b>Background/Objectives:</b> Patients with inflammatory bowel disease (IBD) are at a higher risk of developing bone disorders. Awareness and understanding of the disease are crucial for prevention and early diagnosis. Currently, there is no research on the risk factors and knowledge of...
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2025-03-01
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| author | Yao-Wei Kuo Chia-Jung Kuo Puo-Hsien Le Ming-Ling Chang Cheng-Yu Lin Chen-Ming Hsu Wei-Pin Lin Chun-Wei Chen Wey-Ran Lin Yu-Pin Ho Ming-Yao Su Cheng-Tang Chiu |
| author_facet | Yao-Wei Kuo Chia-Jung Kuo Puo-Hsien Le Ming-Ling Chang Cheng-Yu Lin Chen-Ming Hsu Wei-Pin Lin Chun-Wei Chen Wey-Ran Lin Yu-Pin Ho Ming-Yao Su Cheng-Tang Chiu |
| author_sort | Yao-Wei Kuo |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> Patients with inflammatory bowel disease (IBD) are at a higher risk of developing bone disorders. Awareness and understanding of the disease are crucial for prevention and early diagnosis. Currently, there is no research on the risk factors and knowledge of bone fragility in the population with IBD in Taiwan. This study aimed to evaluate the risk factors and self-assessed knowledge levels of bone health among patients with IBD in Taiwan. <b>Methods:</b> This single-center cross-sectional study included 59 adult patients. Clinical data, blood tests, bone mineral density (BMD), T-score, Z-score, and questionnaires covering self-assessed knowledge, fracture risks, and physical activity were assessed. The patients were divided into normal and low BMD groups. <b>Results:</b> Of all participants, eighteen (30.5%) had low BMD: six (10.2%) had BMD below the expected range, ten (16.9%) had osteopenia, and two (3.4%) had osteoporosis. Vitamin D insufficiency and deficiency were observed in 26.3% and 66.6% of the patients, respectively. According to multivariate analysis, age and sex hormone deficiency are strongly associated with low BMD. Educational interventions significantly improved the patients’ self-assessed knowledge levels. <b>Conclusions:</b> Age and sex hormone deficiency are significant factors contributing to low BMD in IBD patients. Not only women but also men with IBD who had symptoms of hypogonadism are at high risk for low BMD. Educational interventions improve self-assessment knowledge regarding the relationship between IBD and bone health. |
| format | Article |
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| institution | DOAJ |
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| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-0c344d2035f94247a4b39392364346eb2025-08-20T02:42:35ZengMDPI AGBiomedicines2227-90592025-03-0113363810.3390/biomedicines13030638Risk Factors and Awareness of Bone Fragility in Inflammatory Bowel Disease in Taiwan: A Cross-Sectional StudyYao-Wei Kuo0Chia-Jung Kuo1Puo-Hsien Le2Ming-Ling Chang3Cheng-Yu Lin4Chen-Ming Hsu5Wei-Pin Lin6Chun-Wei Chen7Wey-Ran Lin8Yu-Pin Ho9Ming-Yao Su10Cheng-Tang Chiu11Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou 333423, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou 333423, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou 333423, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou 333423, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou 333423, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou 333423, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou 333423, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou 333423, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou 333423, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou 333423, TaiwanCollege of Medicine, Chang Gung University, Taoyuan 333001, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou 333423, Taiwan<b>Background/Objectives:</b> Patients with inflammatory bowel disease (IBD) are at a higher risk of developing bone disorders. Awareness and understanding of the disease are crucial for prevention and early diagnosis. Currently, there is no research on the risk factors and knowledge of bone fragility in the population with IBD in Taiwan. This study aimed to evaluate the risk factors and self-assessed knowledge levels of bone health among patients with IBD in Taiwan. <b>Methods:</b> This single-center cross-sectional study included 59 adult patients. Clinical data, blood tests, bone mineral density (BMD), T-score, Z-score, and questionnaires covering self-assessed knowledge, fracture risks, and physical activity were assessed. The patients were divided into normal and low BMD groups. <b>Results:</b> Of all participants, eighteen (30.5%) had low BMD: six (10.2%) had BMD below the expected range, ten (16.9%) had osteopenia, and two (3.4%) had osteoporosis. Vitamin D insufficiency and deficiency were observed in 26.3% and 66.6% of the patients, respectively. According to multivariate analysis, age and sex hormone deficiency are strongly associated with low BMD. Educational interventions significantly improved the patients’ self-assessed knowledge levels. <b>Conclusions:</b> Age and sex hormone deficiency are significant factors contributing to low BMD in IBD patients. Not only women but also men with IBD who had symptoms of hypogonadism are at high risk for low BMD. Educational interventions improve self-assessment knowledge regarding the relationship between IBD and bone health.https://www.mdpi.com/2227-9059/13/3/638Crohn’s diseaseulcerative colitisinflammatory bowel diseaseosteoporosisawarenessknowledge |
| spellingShingle | Yao-Wei Kuo Chia-Jung Kuo Puo-Hsien Le Ming-Ling Chang Cheng-Yu Lin Chen-Ming Hsu Wei-Pin Lin Chun-Wei Chen Wey-Ran Lin Yu-Pin Ho Ming-Yao Su Cheng-Tang Chiu Risk Factors and Awareness of Bone Fragility in Inflammatory Bowel Disease in Taiwan: A Cross-Sectional Study Biomedicines Crohn’s disease ulcerative colitis inflammatory bowel disease osteoporosis awareness knowledge |
| title | Risk Factors and Awareness of Bone Fragility in Inflammatory Bowel Disease in Taiwan: A Cross-Sectional Study |
| title_full | Risk Factors and Awareness of Bone Fragility in Inflammatory Bowel Disease in Taiwan: A Cross-Sectional Study |
| title_fullStr | Risk Factors and Awareness of Bone Fragility in Inflammatory Bowel Disease in Taiwan: A Cross-Sectional Study |
| title_full_unstemmed | Risk Factors and Awareness of Bone Fragility in Inflammatory Bowel Disease in Taiwan: A Cross-Sectional Study |
| title_short | Risk Factors and Awareness of Bone Fragility in Inflammatory Bowel Disease in Taiwan: A Cross-Sectional Study |
| title_sort | risk factors and awareness of bone fragility in inflammatory bowel disease in taiwan a cross sectional study |
| topic | Crohn’s disease ulcerative colitis inflammatory bowel disease osteoporosis awareness knowledge |
| url | https://www.mdpi.com/2227-9059/13/3/638 |
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