Correlation of Hepatitis C Antibody Levels in Gingival Crevicular Fluid and Saliva of Hepatitis C Seropositive Hemodialysis Patients
Search for hepatitis C virus (HCV) in body fluids other than blood is important when assessing possible nonparenteral routes of viral transmission. However, the role of oral fluids in HCV transmission remains controversial. Our aim was to compare the prevalence of HCV antibody (HCV Ab) levels in sal...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
|
| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2009/247121 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849308987812478976 |
|---|---|
| author | Gökhan Açıkgöz Murat İnanç Cengiz İlker Keskiner Şereften Açıkgöz Murat Can Aydan Açıkgöz |
| author_facet | Gökhan Açıkgöz Murat İnanç Cengiz İlker Keskiner Şereften Açıkgöz Murat Can Aydan Açıkgöz |
| author_sort | Gökhan Açıkgöz |
| collection | DOAJ |
| description | Search for hepatitis C virus (HCV) in body fluids other than blood is important when assessing possible nonparenteral routes of viral transmission. However, the role of oral fluids in HCV transmission remains controversial. Our aim was to compare the prevalence of HCV antibody (HCV Ab) levels in saliva, and gingival crevicular fluid (GCF) of HCV seropositive hemodialysis patients. Serum, saliva and GCF samples were collected from thirty-nine patients. Samples were analyzed for HCV Ab using the Ortho HCV 3.0 SAVe enzyme-linked immunosorbent assay (ELISA). HCH Ab levels in saliva and GCF of all HCV-seropositive patients were statistically compared. Reported here are the results of the study designed to determine the correlation between HCV-RNA positivity in serum and the detection of antibodies in GCF and saliva. One hundred percent (100%) of the 39 patients have antibodies to HCV in their serum, 15.4% have antibodies to HCV in GCF, and saliva found out. HCV Ab seropositivity in GCF and saliva was significantly correlated (kappa = 0.462; 𝑃<.001). This study supports the concept that GCF may be a significant source of HCV in saliva. |
| format | Article |
| id | doaj-art-0c326a95f91c4f0c8dba80ac5c2f3ad8 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-0c326a95f91c4f0c8dba80ac5c2f3ad82025-08-20T03:54:19ZengWileyInternational Journal of Dentistry1687-87281687-87362009-01-01200910.1155/2009/247121247121Correlation of Hepatitis C Antibody Levels in Gingival Crevicular Fluid and Saliva of Hepatitis C Seropositive Hemodialysis PatientsGökhan Açıkgöz0Murat İnanç Cengiz1İlker Keskiner2Şereften Açıkgöz3Murat Can4Aydan Açıkgöz5Department of Periodontology, Faculty of Dentistry, Ondokuz Mayis University, Samsun, TurkeyDepartment of Periodontology, Faculty of Dentistry, Ondokuz Mayis University, Samsun, TurkeyDepartment of Periodontology, Faculty of Dentistry, Ondokuz Mayis University, Samsun, TurkeyDepartment of Biochemistry, Faculty of Medicine, Karaelmas University, Zonguldak, TurkeyDepartment of Biochemistry, Faculty of Medicine, Karaelmas University, Zonguldak, TurkeyDepartment of Oral Diagnosis and Radiology, Faculty of Dentistry, Ondokuz Mayis University, Samsun, TurkeySearch for hepatitis C virus (HCV) in body fluids other than blood is important when assessing possible nonparenteral routes of viral transmission. However, the role of oral fluids in HCV transmission remains controversial. Our aim was to compare the prevalence of HCV antibody (HCV Ab) levels in saliva, and gingival crevicular fluid (GCF) of HCV seropositive hemodialysis patients. Serum, saliva and GCF samples were collected from thirty-nine patients. Samples were analyzed for HCV Ab using the Ortho HCV 3.0 SAVe enzyme-linked immunosorbent assay (ELISA). HCH Ab levels in saliva and GCF of all HCV-seropositive patients were statistically compared. Reported here are the results of the study designed to determine the correlation between HCV-RNA positivity in serum and the detection of antibodies in GCF and saliva. One hundred percent (100%) of the 39 patients have antibodies to HCV in their serum, 15.4% have antibodies to HCV in GCF, and saliva found out. HCV Ab seropositivity in GCF and saliva was significantly correlated (kappa = 0.462; 𝑃<.001). This study supports the concept that GCF may be a significant source of HCV in saliva.http://dx.doi.org/10.1155/2009/247121 |
| spellingShingle | Gökhan Açıkgöz Murat İnanç Cengiz İlker Keskiner Şereften Açıkgöz Murat Can Aydan Açıkgöz Correlation of Hepatitis C Antibody Levels in Gingival Crevicular Fluid and Saliva of Hepatitis C Seropositive Hemodialysis Patients International Journal of Dentistry |
| title | Correlation of Hepatitis C Antibody Levels in Gingival Crevicular Fluid and Saliva of Hepatitis C Seropositive Hemodialysis Patients |
| title_full | Correlation of Hepatitis C Antibody Levels in Gingival Crevicular Fluid and Saliva of Hepatitis C Seropositive Hemodialysis Patients |
| title_fullStr | Correlation of Hepatitis C Antibody Levels in Gingival Crevicular Fluid and Saliva of Hepatitis C Seropositive Hemodialysis Patients |
| title_full_unstemmed | Correlation of Hepatitis C Antibody Levels in Gingival Crevicular Fluid and Saliva of Hepatitis C Seropositive Hemodialysis Patients |
| title_short | Correlation of Hepatitis C Antibody Levels in Gingival Crevicular Fluid and Saliva of Hepatitis C Seropositive Hemodialysis Patients |
| title_sort | correlation of hepatitis c antibody levels in gingival crevicular fluid and saliva of hepatitis c seropositive hemodialysis patients |
| url | http://dx.doi.org/10.1155/2009/247121 |
| work_keys_str_mv | AT gokhanacıkgoz correlationofhepatitiscantibodylevelsingingivalcrevicularfluidandsalivaofhepatitiscseropositivehemodialysispatients AT muratinanccengiz correlationofhepatitiscantibodylevelsingingivalcrevicularfluidandsalivaofhepatitiscseropositivehemodialysispatients AT ilkerkeskiner correlationofhepatitiscantibodylevelsingingivalcrevicularfluidandsalivaofhepatitiscseropositivehemodialysispatients AT sereftenacıkgoz correlationofhepatitiscantibodylevelsingingivalcrevicularfluidandsalivaofhepatitiscseropositivehemodialysispatients AT muratcan correlationofhepatitiscantibodylevelsingingivalcrevicularfluidandsalivaofhepatitiscseropositivehemodialysispatients AT aydanacıkgoz correlationofhepatitiscantibodylevelsingingivalcrevicularfluidandsalivaofhepatitiscseropositivehemodialysispatients |