Construction of organoids using bioprinting technology: a frontier exploration of cartilage repair
Articular cartilage defects caused by trauma or degeneration severely impair patient function. Cartilage repair organoids represent a transformative approach in regenerative medicine to address these challenges. This review focuses on the development and therapeutic potential of such organoids, deta...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Journal of Orthopaedic Translation |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X25001135 |
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| author | Jingtao Huang Shicheng Jia Rongji Liang Aikang Li Lin Li Haojian Wang Jiayou Chen Haoxian Tang Xuan Zhang Jianjing Lin Xintao Zhang |
| author_facet | Jingtao Huang Shicheng Jia Rongji Liang Aikang Li Lin Li Haojian Wang Jiayou Chen Haoxian Tang Xuan Zhang Jianjing Lin Xintao Zhang |
| author_sort | Jingtao Huang |
| collection | DOAJ |
| description | Articular cartilage defects caused by trauma or degeneration severely impair patient function. Cartilage repair organoids represent a transformative approach in regenerative medicine to address these challenges. This review focuses on the development and therapeutic potential of such organoids, detailing their role in overcoming limitations of conventional treatments. Central to this progress, bioprinting technology enables precise organoid fabrication by advancing organoid-compatible bioinks and printing techniques. We further examine applications in disease modeling and drug screening, alongside pathways for clinical translation. As organoid engineering matures, it promises to deliver effective, patient-specific solutions for cartilage restoration.The Translational Potential Statement: The Translational Potential of this Article: 3D-bioprinted cartilage organoids exhibit outstanding efficacy in animal models and hold promise for future clinical trials. The bioinks and printing technologies are distilled to promote basic research toward translation of cartilage repair. |
| format | Article |
| id | doaj-art-0c2d19e9baa242ecb763b940b830a717 |
| institution | Kabale University |
| issn | 2214-031X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj-art-0c2d19e9baa242ecb763b940b830a7172025-08-20T03:50:54ZengElsevierJournal of Orthopaedic Translation2214-031X2025-09-0154375010.1016/j.jot.2025.06.020Construction of organoids using bioprinting technology: a frontier exploration of cartilage repairJingtao Huang0Shicheng Jia1Rongji Liang2Aikang Li3Lin Li4Haojian Wang5Jiayou Chen6Haoxian Tang7Xuan Zhang8Jianjing Lin9Xintao Zhang10Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China; Department of Clinical Medicine, Shantou University Medical College, Shantou, Guangdong, 515041, ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China; Department of Clinical Medicine, Shantou University Medical College, Shantou, Guangdong, 515041, ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China; Department of Clinical Medicine, Shantou University Medical College, Shantou, Guangdong, 515041, ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China; Department of Clinical Medicine, Shantou University Medical College, Shantou, Guangdong, 515041, ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China; Department of Clinical Medicine, Shantou University Medical College, Shantou, Guangdong, 515041, ChinaDepartment of Clinical Medicine, Shantou University Medical College, Shantou, Guangdong, 515041, China; Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China; Corresponding author. Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China.Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China; Corresponding author. Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, 518036, China.Articular cartilage defects caused by trauma or degeneration severely impair patient function. Cartilage repair organoids represent a transformative approach in regenerative medicine to address these challenges. This review focuses on the development and therapeutic potential of such organoids, detailing their role in overcoming limitations of conventional treatments. Central to this progress, bioprinting technology enables precise organoid fabrication by advancing organoid-compatible bioinks and printing techniques. We further examine applications in disease modeling and drug screening, alongside pathways for clinical translation. As organoid engineering matures, it promises to deliver effective, patient-specific solutions for cartilage restoration.The Translational Potential Statement: The Translational Potential of this Article: 3D-bioprinted cartilage organoids exhibit outstanding efficacy in animal models and hold promise for future clinical trials. The bioinks and printing technologies are distilled to promote basic research toward translation of cartilage repair.http://www.sciencedirect.com/science/article/pii/S2214031X25001135Cartilage repairOrganoidsTissue engineeringBioprintingBiomaterials |
| spellingShingle | Jingtao Huang Shicheng Jia Rongji Liang Aikang Li Lin Li Haojian Wang Jiayou Chen Haoxian Tang Xuan Zhang Jianjing Lin Xintao Zhang Construction of organoids using bioprinting technology: a frontier exploration of cartilage repair Journal of Orthopaedic Translation Cartilage repair Organoids Tissue engineering Bioprinting Biomaterials |
| title | Construction of organoids using bioprinting technology: a frontier exploration of cartilage repair |
| title_full | Construction of organoids using bioprinting technology: a frontier exploration of cartilage repair |
| title_fullStr | Construction of organoids using bioprinting technology: a frontier exploration of cartilage repair |
| title_full_unstemmed | Construction of organoids using bioprinting technology: a frontier exploration of cartilage repair |
| title_short | Construction of organoids using bioprinting technology: a frontier exploration of cartilage repair |
| title_sort | construction of organoids using bioprinting technology a frontier exploration of cartilage repair |
| topic | Cartilage repair Organoids Tissue engineering Bioprinting Biomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X25001135 |
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