Evaluation of the effects of sodium valproate on plasma homocysteine, folate and vitamin B12 levels in epileptic patients
Objective: to investigate the effects of sodium valproate on plasma concentrations of homocysteine, folate and vitamin B12 levels in epileptic patients with long-standing tonic-clonic seizures compared to newly diagnosed epileptic patients and healthy controls.Material and methods. The study include...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2024-07-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/1045 |
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| author | A. Aman-Mohammady D. Qujeq P. Saadat K. Hajian-Tilaki |
| author_facet | A. Aman-Mohammady D. Qujeq P. Saadat K. Hajian-Tilaki |
| author_sort | A. Aman-Mohammady |
| collection | DOAJ |
| description | Objective: to investigate the effects of sodium valproate on plasma concentrations of homocysteine, folate and vitamin B12 levels in epileptic patients with long-standing tonic-clonic seizures compared to newly diagnosed epileptic patients and healthy controls.Material and methods. The study included 90 participants (mean age 36.30±12.83 years, the majority (58.89%) were males) divided into three groups: 30 non-epileptic people (control Group 1), 30 newly diagnosed epileptic patients (Group 2), and 30 patients with long-term tonic-clonic seizures epilepsy (Group 3). In Group 3, patients received sodium valproate therapy. All subjects underwent clinical and neurological examinations. Differences in plasma levels of homocysteine, folic acid and vitamin B12 in three groups were investigated after 6 months of follow-up.Results. Homocysteine level in Groups 2 and 3 was increased; for Group 2 it was significantly higher than for Groups 3 and 1 (p=0.001). Plasma folate level in Groups 2 and 3 was decreased; for Group 3 it was significantly higher than for Group 2 and lower than for Group 1 (p=0.001). Vitamin B12 level in Groups 2 and 3 was decreased, but the difference was not significant (p=0.090). In Groups 1 and 2, a significant correlation was observed between the indicators.Conclusion. Sodium valproate аdministration might disrupt the homeostatic level of homocysteine, folate and vitamin B12 and cause irregularity of their plasma contents in epileptic patients with long-standing tonic-clonic seizures. |
| format | Article |
| id | doaj-art-0c292e9ada2048d4b940c070e8befbd0 |
| institution | Kabale University |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| publishDate | 2024-07-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj-art-0c292e9ada2048d4b940c070e8befbd02025-08-20T03:39:32ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882024-07-0116210410910.17749/2077-8333/epi.par.con.2024.169643Evaluation of the effects of sodium valproate on plasma homocysteine, folate and vitamin B12 levels in epileptic patientsA. Aman-Mohammady0D. Qujeq1P. Saadat2K. Hajian-Tilaki3Babol University of Medical SciencesBabol University of Medical SciencesBabol University of Medical SciencesBabol University of Medical SciencesObjective: to investigate the effects of sodium valproate on plasma concentrations of homocysteine, folate and vitamin B12 levels in epileptic patients with long-standing tonic-clonic seizures compared to newly diagnosed epileptic patients and healthy controls.Material and methods. The study included 90 participants (mean age 36.30±12.83 years, the majority (58.89%) were males) divided into three groups: 30 non-epileptic people (control Group 1), 30 newly diagnosed epileptic patients (Group 2), and 30 patients with long-term tonic-clonic seizures epilepsy (Group 3). In Group 3, patients received sodium valproate therapy. All subjects underwent clinical and neurological examinations. Differences in plasma levels of homocysteine, folic acid and vitamin B12 in three groups were investigated after 6 months of follow-up.Results. Homocysteine level in Groups 2 and 3 was increased; for Group 2 it was significantly higher than for Groups 3 and 1 (p=0.001). Plasma folate level in Groups 2 and 3 was decreased; for Group 3 it was significantly higher than for Group 2 and lower than for Group 1 (p=0.001). Vitamin B12 level in Groups 2 and 3 was decreased, but the difference was not significant (p=0.090). In Groups 1 and 2, a significant correlation was observed between the indicators.Conclusion. Sodium valproate аdministration might disrupt the homeostatic level of homocysteine, folate and vitamin B12 and cause irregularity of their plasma contents in epileptic patients with long-standing tonic-clonic seizures.https://www.epilepsia.su/jour/article/view/1045newly diagnosed epileptic seizureslong-standing epilepsysodium valproatefolatehomocysteinevitamin b12 |
| spellingShingle | A. Aman-Mohammady D. Qujeq P. Saadat K. Hajian-Tilaki Evaluation of the effects of sodium valproate on plasma homocysteine, folate and vitamin B12 levels in epileptic patients Эпилепсия и пароксизмальные состояния newly diagnosed epileptic seizures long-standing epilepsy sodium valproate folate homocysteine vitamin b12 |
| title | Evaluation of the effects of sodium valproate on plasma homocysteine, folate and vitamin B12 levels in epileptic patients |
| title_full | Evaluation of the effects of sodium valproate on plasma homocysteine, folate and vitamin B12 levels in epileptic patients |
| title_fullStr | Evaluation of the effects of sodium valproate on plasma homocysteine, folate and vitamin B12 levels in epileptic patients |
| title_full_unstemmed | Evaluation of the effects of sodium valproate on plasma homocysteine, folate and vitamin B12 levels in epileptic patients |
| title_short | Evaluation of the effects of sodium valproate on plasma homocysteine, folate and vitamin B12 levels in epileptic patients |
| title_sort | evaluation of the effects of sodium valproate on plasma homocysteine folate and vitamin b12 levels in epileptic patients |
| topic | newly diagnosed epileptic seizures long-standing epilepsy sodium valproate folate homocysteine vitamin b12 |
| url | https://www.epilepsia.su/jour/article/view/1045 |
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