Characterisation of an autochthonous mouse ccRCC model of immune checkpoint inhibitor therapy resistance

Characterisation of an autochthonous mouse ccRCC model of immune checkpoint inhibitor therapy resistance

Abstract Many metastatic clear cell renal cell carcinomas (ccRCC) are resistant to immune checkpoint inhibitor therapies, however the mechanisms underlying sensitivity or resistance remain incompletely characterised. We demonstrate that ccRCCs in the Vhl/Trp53/Rb1 mutant mouse model are resistant to...

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Main Authors: Asin Peighambari, Hsin Huang, Patrick Metzger, Mojca Adlesic, Kyra Zodel, Silvia Schäfer, Philipp Seidel, Lukas M. Braun, Jan Hülsdünker, Wolfgang Melchinger, Marie Follo, Manching Ku, Stefan Haug, Yong Li, Anna Köttgen, Christoph Schell, Dominik von Elverfeldt, Wilfried Reichardt, Robert Zeiser, Mathias Heikenwalder, Rouven Höfflin, Melanie Börries, Ian J. Frew
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-04917-1
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