Incorporation of Silver into Sulfate Groups Enhances Antimicrobial and Antiviral Effects of Fucoidan
The COVID-19 pandemic has significantly impacted our daily lives. Routine infection-control measures present an effective preventive strategy for a new infectious disease outbreak. Fucoidan, a fucose-rich sulfated polysaccharide found in brown algae, exhibits antiviral activity. Moreover, fucoidan e...
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MDPI AG
2024-10-01
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| author | Akira Iwata Mayuko Yamamoto-Fujimura Suzuka Fujiwara Saya Tajima Takahide Shigeyama Moriya Tsukimoto Tatsuya Ibuki Akito Kataoka-Kato |
| author_facet | Akira Iwata Mayuko Yamamoto-Fujimura Suzuka Fujiwara Saya Tajima Takahide Shigeyama Moriya Tsukimoto Tatsuya Ibuki Akito Kataoka-Kato |
| author_sort | Akira Iwata |
| collection | DOAJ |
| description | The COVID-19 pandemic has significantly impacted our daily lives. Routine infection-control measures present an effective preventive strategy for a new infectious disease outbreak. Fucoidan, a fucose-rich sulfated polysaccharide found in brown algae, exhibits antiviral activity. Moreover, fucoidan exerts an antimicrobial effect; however, it requires considerably higher concentrations than those needed for its antiviral effect. In this study, we aimed to enhance the antimicrobial activity of fucoidan and prepared a fucoidan silver salt (Ag-Fuc) by incorporating silver ions into the sulfate groups of Yakult Fucoidan derived from <i>Cladosiphon okamuranus</i> Tokida. The fucoidan exhibited a weak inhibitory effect on <i>Escherichia coli</i> growth at significantly higher concentrations, whereas Ag-Fuc inhibited the growth of <i>E. coli</i> and <i>Staphylococcus epidermidis</i> at concentrations comparable to those required for its antiviral effects. Moreover, Ag-Fuc inhibited the growth of <i>Cladosporium cladosporioides</i>. Infections of human cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus were more effectively inhibited by lower concentrations of Ag-Fuc compared with fucoidan. Overall, silver ions added to the sulfate groups induced strong antimicrobial activity and enhanced the antiviral effect of fucoidan. We suggest a wide application of Ag-Fuc as a routine preventive material to avoid new infectious disease pandemics. |
| format | Article |
| id | doaj-art-0c1df2c8c804443dbfb64e5e3aefdc96 |
| institution | DOAJ |
| issn | 1660-3397 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
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| series | Marine Drugs |
| spelling | doaj-art-0c1df2c8c804443dbfb64e5e3aefdc962025-08-20T02:47:59ZengMDPI AGMarine Drugs1660-33972024-10-01221148610.3390/md22110486Incorporation of Silver into Sulfate Groups Enhances Antimicrobial and Antiviral Effects of FucoidanAkira Iwata0Mayuko Yamamoto-Fujimura1Suzuka Fujiwara2Saya Tajima3Takahide Shigeyama4Moriya Tsukimoto5Tatsuya Ibuki6Akito Kataoka-Kato7Yakult Central Institute, 5-11 Izumi, Kunitachi, Tokyo 186-8650, JapanYakult Central Institute, 5-11 Izumi, Kunitachi, Tokyo 186-8650, JapanYakult Central Institute, 5-11 Izumi, Kunitachi, Tokyo 186-8650, JapanYakult Central Institute, 5-11 Izumi, Kunitachi, Tokyo 186-8650, JapanYakult Central Institute, 5-11 Izumi, Kunitachi, Tokyo 186-8650, JapanYakult Central Institute, 5-11 Izumi, Kunitachi, Tokyo 186-8650, JapanYakult Central Institute, 5-11 Izumi, Kunitachi, Tokyo 186-8650, JapanYakult Central Institute, 5-11 Izumi, Kunitachi, Tokyo 186-8650, JapanThe COVID-19 pandemic has significantly impacted our daily lives. Routine infection-control measures present an effective preventive strategy for a new infectious disease outbreak. Fucoidan, a fucose-rich sulfated polysaccharide found in brown algae, exhibits antiviral activity. Moreover, fucoidan exerts an antimicrobial effect; however, it requires considerably higher concentrations than those needed for its antiviral effect. In this study, we aimed to enhance the antimicrobial activity of fucoidan and prepared a fucoidan silver salt (Ag-Fuc) by incorporating silver ions into the sulfate groups of Yakult Fucoidan derived from <i>Cladosiphon okamuranus</i> Tokida. The fucoidan exhibited a weak inhibitory effect on <i>Escherichia coli</i> growth at significantly higher concentrations, whereas Ag-Fuc inhibited the growth of <i>E. coli</i> and <i>Staphylococcus epidermidis</i> at concentrations comparable to those required for its antiviral effects. Moreover, Ag-Fuc inhibited the growth of <i>Cladosporium cladosporioides</i>. Infections of human cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus were more effectively inhibited by lower concentrations of Ag-Fuc compared with fucoidan. Overall, silver ions added to the sulfate groups induced strong antimicrobial activity and enhanced the antiviral effect of fucoidan. We suggest a wide application of Ag-Fuc as a routine preventive material to avoid new infectious disease pandemics.https://www.mdpi.com/1660-3397/22/11/486SARS-CoV-2fucoidansilverinfluenza virusantibacterial activityantifungal activity |
| spellingShingle | Akira Iwata Mayuko Yamamoto-Fujimura Suzuka Fujiwara Saya Tajima Takahide Shigeyama Moriya Tsukimoto Tatsuya Ibuki Akito Kataoka-Kato Incorporation of Silver into Sulfate Groups Enhances Antimicrobial and Antiviral Effects of Fucoidan Marine Drugs SARS-CoV-2 fucoidan silver influenza virus antibacterial activity antifungal activity |
| title | Incorporation of Silver into Sulfate Groups Enhances Antimicrobial and Antiviral Effects of Fucoidan |
| title_full | Incorporation of Silver into Sulfate Groups Enhances Antimicrobial and Antiviral Effects of Fucoidan |
| title_fullStr | Incorporation of Silver into Sulfate Groups Enhances Antimicrobial and Antiviral Effects of Fucoidan |
| title_full_unstemmed | Incorporation of Silver into Sulfate Groups Enhances Antimicrobial and Antiviral Effects of Fucoidan |
| title_short | Incorporation of Silver into Sulfate Groups Enhances Antimicrobial and Antiviral Effects of Fucoidan |
| title_sort | incorporation of silver into sulfate groups enhances antimicrobial and antiviral effects of fucoidan |
| topic | SARS-CoV-2 fucoidan silver influenza virus antibacterial activity antifungal activity |
| url | https://www.mdpi.com/1660-3397/22/11/486 |
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