Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough?
Background Recently, cough reflex hypersensitivity has been proposed as a common underlying feature of chronic cough in adults. However, symptoms and clinical characteristics of cough hypersensitivity have not been studied amongst phenotypes of chronic cough. This study aimed to compare symptom feat...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-11-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/6/00260-2024.full |
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| author | Mi-Yeong Kim Ha-Kyeong Won Ji-Yoon Oh Ji-Hyang Lee Eun-Jung Jo Sung-Yoon Kang Ji-Ho Lee Seung-Eun Lee Noeul Kang Young-Chan Kim Hwa Young Lee Jin An Youngsang Yoo Ji-Su Shim So-Young Park Han-Ki Park Min-Hye Kim Sae-Hoon Kim Sang-Heon Kim Yoon-Seok Chang Sang-Hoon Kim Byung-Jae Lee Surinder S. Birring Woo-Jung Song |
| author_facet | Mi-Yeong Kim Ha-Kyeong Won Ji-Yoon Oh Ji-Hyang Lee Eun-Jung Jo Sung-Yoon Kang Ji-Ho Lee Seung-Eun Lee Noeul Kang Young-Chan Kim Hwa Young Lee Jin An Youngsang Yoo Ji-Su Shim So-Young Park Han-Ki Park Min-Hye Kim Sae-Hoon Kim Sang-Heon Kim Yoon-Seok Chang Sang-Hoon Kim Byung-Jae Lee Surinder S. Birring Woo-Jung Song |
| author_sort | Mi-Yeong Kim |
| collection | DOAJ |
| description | Background
Recently, cough reflex hypersensitivity has been proposed as a common underlying feature of chronic cough in adults. However, symptoms and clinical characteristics of cough hypersensitivity have not been studied amongst phenotypes of chronic cough. This study aimed to compare symptom features, such as cough triggers and associated throat sensations, of cough hypersensitivity in patients with asthmatic chronic cough and those with refractory chronic cough (RCC).
Methods
Patients with chronic cough from the Korean Chronic Cough Registry were prospectively evaluated over 6 months. Physicians determined the aetiological diagnosis based on clinical evaluations and responses to treatment at the 6-month follow-up visit. Symptoms of cough hypersensitivity and cough-specific quality of life were assessed using the Cough Hypersensitivity Questionnaire (CHQ) and the Leicester Cough Questionnaire (LCQ), respectively.
Results
The analysis included 280 patients who completed the follow-up: 79 with asthmatic cough (cough variant asthma or eosinophilic bronchitis) and 201 with RCC. Baseline CHQ scores were similar between the groups (8.3±3.7 in asthmatic cough versus 8.9±3.9 in RCC; p=0.215, adjusted for age, sex and LCQ score). There were no significant between-group differences in the LCQ and cough severity Visual Analog Scale scores. Both groups showed a similar negative correlation with LCQ scores (asthmatic cough: r=−0.427, p<0.001; RCC: r=−0.306, p<0.001).
Conclusions
The symptoms of cough hypersensitivity may not distinguish between asthmatic cough and RCC. This suggests that chronic cough is the primary diagnosis in both phenotypes. It indicates a shared mechanism in their cough pathogenesis, despite having potentially different treatable traits. |
| format | Article |
| id | doaj-art-0c1d19f2f50d4441961aa54ebe12653e |
| institution | Kabale University |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-0c1d19f2f50d4441961aa54ebe12653e2025-01-14T09:50:21ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-11-0110610.1183/23120541.00260-202400260-2024Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough?Mi-Yeong Kim0Ha-Kyeong Won1Ji-Yoon Oh2Ji-Hyang Lee3Eun-Jung Jo4Sung-Yoon Kang5Ji-Ho Lee6Seung-Eun Lee7Noeul Kang8Young-Chan Kim9Hwa Young Lee10Jin An11Youngsang Yoo12Ji-Su Shim13So-Young Park14Han-Ki Park15Min-Hye Kim16Sae-Hoon Kim17Sang-Heon Kim18Yoon-Seok Chang19Sang-Hoon Kim20Byung-Jae Lee21Surinder S. Birring22Woo-Jung Song23 Department of Internal Medicine, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Internal Medicine, School of Medicine, Pusan National University, Busan, Korea Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Internal Medicine, School of Medicine, Pusan National University, Busan, Korea Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea Division of Allergy, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea Department of Internal Medicine, Gangneung Asan Hospital, Gangneung, Korea Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea Department of Internal Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Chung-Ang University College of Medicine, Seoul, Korea Division of Allergy and Clinical Immunology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Korea Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea Division of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Background Recently, cough reflex hypersensitivity has been proposed as a common underlying feature of chronic cough in adults. However, symptoms and clinical characteristics of cough hypersensitivity have not been studied amongst phenotypes of chronic cough. This study aimed to compare symptom features, such as cough triggers and associated throat sensations, of cough hypersensitivity in patients with asthmatic chronic cough and those with refractory chronic cough (RCC). Methods Patients with chronic cough from the Korean Chronic Cough Registry were prospectively evaluated over 6 months. Physicians determined the aetiological diagnosis based on clinical evaluations and responses to treatment at the 6-month follow-up visit. Symptoms of cough hypersensitivity and cough-specific quality of life were assessed using the Cough Hypersensitivity Questionnaire (CHQ) and the Leicester Cough Questionnaire (LCQ), respectively. Results The analysis included 280 patients who completed the follow-up: 79 with asthmatic cough (cough variant asthma or eosinophilic bronchitis) and 201 with RCC. Baseline CHQ scores were similar between the groups (8.3±3.7 in asthmatic cough versus 8.9±3.9 in RCC; p=0.215, adjusted for age, sex and LCQ score). There were no significant between-group differences in the LCQ and cough severity Visual Analog Scale scores. Both groups showed a similar negative correlation with LCQ scores (asthmatic cough: r=−0.427, p<0.001; RCC: r=−0.306, p<0.001). Conclusions The symptoms of cough hypersensitivity may not distinguish between asthmatic cough and RCC. This suggests that chronic cough is the primary diagnosis in both phenotypes. It indicates a shared mechanism in their cough pathogenesis, despite having potentially different treatable traits.http://openres.ersjournals.com/content/10/6/00260-2024.full |
| spellingShingle | Mi-Yeong Kim Ha-Kyeong Won Ji-Yoon Oh Ji-Hyang Lee Eun-Jung Jo Sung-Yoon Kang Ji-Ho Lee Seung-Eun Lee Noeul Kang Young-Chan Kim Hwa Young Lee Jin An Youngsang Yoo Ji-Su Shim So-Young Park Han-Ki Park Min-Hye Kim Sae-Hoon Kim Sang-Heon Kim Yoon-Seok Chang Sang-Hoon Kim Byung-Jae Lee Surinder S. Birring Woo-Jung Song Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough? ERJ Open Research |
| title | Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough? |
| title_full | Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough? |
| title_fullStr | Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough? |
| title_full_unstemmed | Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough? |
| title_short | Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough? |
| title_sort | could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough |
| url | http://openres.ersjournals.com/content/10/6/00260-2024.full |
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