Local Therapy Can Enhance the Prognosis of Certain Patients with Pathologically Diagnosed Neuroendocrine Prostate Carcinoma
Neuroendocrine prostate cancer (NEPC) has a poor prognosis. We performed a retrospective analysis of the factors contributing to survival in patients with histologically diagnosed NEPC. Patients pathologically diagnosed with NEPC between 2007 and 2018 were retrospectively analyzed. Overall survival...
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2025-05-01
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| author | Shoichi Kimura Naoki Terada Shinnya Soumiya Takayuki Goto Hiromitsu Negoro Shoichiro Mukai Osamu Ogawa Shusuke Akamatsu Takashi Kobayashi Atsuro Sawada Toshiyuki Kamoto |
| author_facet | Shoichi Kimura Naoki Terada Shinnya Soumiya Takayuki Goto Hiromitsu Negoro Shoichiro Mukai Osamu Ogawa Shusuke Akamatsu Takashi Kobayashi Atsuro Sawada Toshiyuki Kamoto |
| author_sort | Shoichi Kimura |
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| description | Neuroendocrine prostate cancer (NEPC) has a poor prognosis. We performed a retrospective analysis of the factors contributing to survival in patients with histologically diagnosed NEPC. Patients pathologically diagnosed with NEPC between 2007 and 2018 were retrospectively analyzed. Overall survival (OS) from the time of the initial prostate cancer diagnosis was evaluated using the Kaplan–Meier method. Cox proportional hazards analyses were performed to evaluate the association of OS with variables including the presence of metastasis, receipt of local therapy, and disease classification (primary NEPC [p-NEPC] or treatment-related NEPC [t-NEPC]). Among 32 patients (p-NEPC, 22; t-NEPC, 10), distant metastases were identified in 25 (78%) patients, and local therapies including radical prostatectomy and local radiotherapy were provided to 21 (66%) patients. In the univariate Cox proportional hazard analyses, patients who received local therapy had a significantly lower risk of death than those who did not receive local therapy (hazard ratio = 0.284, 95% confidence interval = 0.109–0.738, <i>p</i> = 0.01). OS was significantly longer for patients receiving local therapy than for those who did not receive local therapy (36 months vs. 13 months, <i>p</i> = 0.0058). Our findings suggest the potential benefit of local therapy in the treatment of NEPC. |
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| issn | 2075-1729 |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-0c17c8d2a3924891a1b3bd2cdc45caa72025-08-20T01:56:31ZengMDPI AGLife2075-17292025-05-0115579710.3390/life15050797Local Therapy Can Enhance the Prognosis of Certain Patients with Pathologically Diagnosed Neuroendocrine Prostate CarcinomaShoichi Kimura0Naoki Terada1Shinnya Soumiya2Takayuki Goto3Hiromitsu Negoro4Shoichiro Mukai5Osamu Ogawa6Shusuke Akamatsu7Takashi Kobayashi8Atsuro Sawada9Toshiyuki Kamoto10Department of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1601, JapanDepartment of Urology, Faculty of Medicine, University of Fukui Hospital, Fukui 910-1193, JapanDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, JapanDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, JapanDepartment of Urology, Institute of Medicine, University of Tsukuba, Ibaraki 305-8576, JapanDepartment of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1601, JapanDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, JapanDepartment of Urology, Faculty of Medicine, Nagoya University Graduate School of Medicine, Aichi 466-8550, JapanDepartment of Urology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, JapanDepartment of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1601, JapanDepartment of Urology, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1601, JapanNeuroendocrine prostate cancer (NEPC) has a poor prognosis. We performed a retrospective analysis of the factors contributing to survival in patients with histologically diagnosed NEPC. Patients pathologically diagnosed with NEPC between 2007 and 2018 were retrospectively analyzed. Overall survival (OS) from the time of the initial prostate cancer diagnosis was evaluated using the Kaplan–Meier method. Cox proportional hazards analyses were performed to evaluate the association of OS with variables including the presence of metastasis, receipt of local therapy, and disease classification (primary NEPC [p-NEPC] or treatment-related NEPC [t-NEPC]). Among 32 patients (p-NEPC, 22; t-NEPC, 10), distant metastases were identified in 25 (78%) patients, and local therapies including radical prostatectomy and local radiotherapy were provided to 21 (66%) patients. In the univariate Cox proportional hazard analyses, patients who received local therapy had a significantly lower risk of death than those who did not receive local therapy (hazard ratio = 0.284, 95% confidence interval = 0.109–0.738, <i>p</i> = 0.01). OS was significantly longer for patients receiving local therapy than for those who did not receive local therapy (36 months vs. 13 months, <i>p</i> = 0.0058). Our findings suggest the potential benefit of local therapy in the treatment of NEPC.https://www.mdpi.com/2075-1729/15/5/797neuroendocrine prostate carcinomalocal therapyprostate cancer |
| spellingShingle | Shoichi Kimura Naoki Terada Shinnya Soumiya Takayuki Goto Hiromitsu Negoro Shoichiro Mukai Osamu Ogawa Shusuke Akamatsu Takashi Kobayashi Atsuro Sawada Toshiyuki Kamoto Local Therapy Can Enhance the Prognosis of Certain Patients with Pathologically Diagnosed Neuroendocrine Prostate Carcinoma Life neuroendocrine prostate carcinoma local therapy prostate cancer |
| title | Local Therapy Can Enhance the Prognosis of Certain Patients with Pathologically Diagnosed Neuroendocrine Prostate Carcinoma |
| title_full | Local Therapy Can Enhance the Prognosis of Certain Patients with Pathologically Diagnosed Neuroendocrine Prostate Carcinoma |
| title_fullStr | Local Therapy Can Enhance the Prognosis of Certain Patients with Pathologically Diagnosed Neuroendocrine Prostate Carcinoma |
| title_full_unstemmed | Local Therapy Can Enhance the Prognosis of Certain Patients with Pathologically Diagnosed Neuroendocrine Prostate Carcinoma |
| title_short | Local Therapy Can Enhance the Prognosis of Certain Patients with Pathologically Diagnosed Neuroendocrine Prostate Carcinoma |
| title_sort | local therapy can enhance the prognosis of certain patients with pathologically diagnosed neuroendocrine prostate carcinoma |
| topic | neuroendocrine prostate carcinoma local therapy prostate cancer |
| url | https://www.mdpi.com/2075-1729/15/5/797 |
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