CTHRC1 Derived From Cancer‐Associated Fibroblasts Promotes Pancreatic Cancer Progression and Metastasis via the LIF‐STAT3 Pathway

CTHRC1 Derived From Cancer‐Associated Fibroblasts Promotes Pancreatic Cancer Progression and Metastasis via the LIF‐STAT3 Pathway

ABSTRACT Background Collagen triple helix repeat containing 1 (CTHRC1) is a secreted protein involved in tissue remodeling and fibrotic processes, which also suggests emerging roles in cancer. Studies have shown that it is mainly expressed in the outer membrane fibroblasts of injured arteries and in...

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Bibliographic Details
Main Authors: Hang Yin, Yue Pan, Zhuang Li, Yong Liu, Jiatong Chen, Xin Chen, Chengfei Zhang, Feng Zhu, Chunzhao Yu
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Cancer Medicine
Subjects:
cancer‐associated fibroblast
CTHRC1
pancreatic cancer
STAT3 signaling pathway
tumor microenvironment
Online Access:https://doi.org/10.1002/cam4.71126
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