The antiarrhythmic activity comparative study of Lappaconitine hydrobromide and LMG-124 on the model of aconitine arrhythmia
Two models of the aconitin-induced cardiac arrhythmias were used to compare the antiarrhythmic and antifibrillatory activity of the reference drug Lappaconitine hydrobromide and the LMG-124 compound. It is shown that both compounds have antiarrhythmic action. At the same time, the compound LMG-124 r...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2017-03-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/12 |
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| author | V. N. Stolyaruk I. B. Tsorin M. B. Vititnova T. D. Nikiforova Yu. I. Murinov M. S. Yunusov S. A. Kryzhanovskii |
| author_facet | V. N. Stolyaruk I. B. Tsorin M. B. Vititnova T. D. Nikiforova Yu. I. Murinov M. S. Yunusov S. A. Kryzhanovskii |
| author_sort | V. N. Stolyaruk |
| collection | DOAJ |
| description | Two models of the aconitin-induced cardiac arrhythmias were used to compare the antiarrhythmic and antifibrillatory activity of the reference drug Lappaconitine hydrobromide and the LMG-124 compound. It is shown that both compounds have antiarrhythmic action. At the same time, the compound LMG-124 realizes its antiarrhythmic effect in a significantly lower dose. In this case, the compound LMG-124 shows a pronounced antifibrillatory activity, in contrast to the reference drug Lappaconitine hydrobromide, which in the studied dose does not exhibit similar activity. |
| format | Article |
| id | doaj-art-0c1048a0516b4cbfb0d58fa34c6a1a8b |
| institution | DOAJ |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2017-03-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-0c1048a0516b4cbfb0d58fa34c6a1a8b2025-08-20T02:49:52ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302017-03-0102121511The antiarrhythmic activity comparative study of Lappaconitine hydrobromide and LMG-124 on the model of aconitine arrhythmiaV. N. Stolyaruk0I. B. Tsorin1M. B. Vititnova2T. D. Nikiforova3Yu. I. Murinov4M. S. Yunusov5S. A. Kryzhanovskii6FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBI «Zakusov Institute of Pharmacology»FSBIS «Ufa Institute of Chemistry of the Russian Academy of Sciences» (UIC RAS)FSBIS «Ufa Institute of Chemistry of the Russian Academy of Sciences» (UIC RAS)FSBI «Zakusov Institute of Pharmacology»Two models of the aconitin-induced cardiac arrhythmias were used to compare the antiarrhythmic and antifibrillatory activity of the reference drug Lappaconitine hydrobromide and the LMG-124 compound. It is shown that both compounds have antiarrhythmic action. At the same time, the compound LMG-124 realizes its antiarrhythmic effect in a significantly lower dose. In this case, the compound LMG-124 shows a pronounced antifibrillatory activity, in contrast to the reference drug Lappaconitine hydrobromide, which in the studied dose does not exhibit similar activity.https://www.pharmacokinetica.ru/jour/article/view/12аконитинлаппаконитина гидробромидлмг-124аритмияфибрилляцияaconitinelappaconitine hydrobromidelmg-124arrhythmiafibrillation |
| spellingShingle | V. N. Stolyaruk I. B. Tsorin M. B. Vititnova T. D. Nikiforova Yu. I. Murinov M. S. Yunusov S. A. Kryzhanovskii The antiarrhythmic activity comparative study of Lappaconitine hydrobromide and LMG-124 on the model of aconitine arrhythmia Фармакокинетика и Фармакодинамика аконитин лаппаконитина гидробромид лмг-124 аритмия фибрилляция aconitine lappaconitine hydrobromide lmg-124 arrhythmia fibrillation |
| title | The antiarrhythmic activity comparative study of Lappaconitine hydrobromide and LMG-124 on the model of aconitine arrhythmia |
| title_full | The antiarrhythmic activity comparative study of Lappaconitine hydrobromide and LMG-124 on the model of aconitine arrhythmia |
| title_fullStr | The antiarrhythmic activity comparative study of Lappaconitine hydrobromide and LMG-124 on the model of aconitine arrhythmia |
| title_full_unstemmed | The antiarrhythmic activity comparative study of Lappaconitine hydrobromide and LMG-124 on the model of aconitine arrhythmia |
| title_short | The antiarrhythmic activity comparative study of Lappaconitine hydrobromide and LMG-124 on the model of aconitine arrhythmia |
| title_sort | antiarrhythmic activity comparative study of lappaconitine hydrobromide and lmg 124 on the model of aconitine arrhythmia |
| topic | аконитин лаппаконитина гидробромид лмг-124 аритмия фибрилляция aconitine lappaconitine hydrobromide lmg-124 arrhythmia fibrillation |
| url | https://www.pharmacokinetica.ru/jour/article/view/12 |
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