Modern approaches for the screening of epigenetically active xenobiotics
Objective. Review of the modern methodological approaches for testing and studying the epigenetic activity of xenobiotics.Materials and methods. In preparing the review, we used information databases of biomedical literature SciVerse Scopus (538), PubMed (746), Web of Science (625), RSCI (45). To ob...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-11-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/229 |
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| author | V. P. Maksimova P. E. Bugaeva E. M. Zhidkova O. G. Usalka E. A. Lesovaya G. A. Belitsky M. G. Yakubovskaya K. I. Kirsanov |
| author_facet | V. P. Maksimova P. E. Bugaeva E. M. Zhidkova O. G. Usalka E. A. Lesovaya G. A. Belitsky M. G. Yakubovskaya K. I. Kirsanov |
| author_sort | V. P. Maksimova |
| collection | DOAJ |
| description | Objective. Review of the modern methodological approaches for testing and studying the epigenetic activity of xenobiotics.Materials and methods. In preparing the review, we used information databases of biomedical literature SciVerse Scopus (538), PubMed (746), Web of Science (625), RSCI (45). To obtain full-text documents, electronic resources of PubMed Central (PMC), Research Gate, RSCI, CyberLeninka were used. In the text of the review, 87 modern publications (2010–2019) were cited, as well as 17 earlier articles published by the founders of the methods, which are used today.Results. In the review, current data on epigenetic regulation for gene expression at the level of DNA methylation and histone modification are discussed, in vitro model systems and model organisms are described, and modern methods for screening of epigenetically active xenobiotics are presented.Conclusion. Modern data concerning the mechanisms of epigenetic regulation of gene expression, the usage of existing model systems and model organisms, as well as the application of various methodological approaches and techniques, allow extensive screening of xenobiotics (including drugs and compounds synthesized for national economic tasks) for epigenetic activity. The identification of epigenetically active compounds is important in terms of improving the prevention and treatment of a number of diseases and, in particular, malignant neoplasms. |
| format | Article |
| id | doaj-art-0c0e894ead4a4c1da5079f47138cbabe |
| institution | Kabale University |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2019-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-0c0e894ead4a4c1da5079f47138cbabe2025-08-20T04:00:14ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872019-11-016382710.17650/2313-805X-2019-6-3-8-27164Modern approaches for the screening of epigenetically active xenobioticsV. P. Maksimova0P. E. Bugaeva1E. M. Zhidkova2O. G. Usalka3E. A. Lesovaya4G. A. Belitsky5M. G. Yakubovskaya6K. I. Kirsanov7N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaSechenov First Moscow State Medical University, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaSechenov First Moscow State Medical University, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; I.P. Pavlov Ryazan State Medical UniversityN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia; Peoples’ Friendship University of RussiaObjective. Review of the modern methodological approaches for testing and studying the epigenetic activity of xenobiotics.Materials and methods. In preparing the review, we used information databases of biomedical literature SciVerse Scopus (538), PubMed (746), Web of Science (625), RSCI (45). To obtain full-text documents, electronic resources of PubMed Central (PMC), Research Gate, RSCI, CyberLeninka were used. In the text of the review, 87 modern publications (2010–2019) were cited, as well as 17 earlier articles published by the founders of the methods, which are used today.Results. In the review, current data on epigenetic regulation for gene expression at the level of DNA methylation and histone modification are discussed, in vitro model systems and model organisms are described, and modern methods for screening of epigenetically active xenobiotics are presented.Conclusion. Modern data concerning the mechanisms of epigenetic regulation of gene expression, the usage of existing model systems and model organisms, as well as the application of various methodological approaches and techniques, allow extensive screening of xenobiotics (including drugs and compounds synthesized for national economic tasks) for epigenetic activity. The identification of epigenetically active compounds is important in terms of improving the prevention and treatment of a number of diseases and, in particular, malignant neoplasms.https://umo.abvpress.ru/jour/article/view/229dna methylationhistone acetylationmodel organismsbisulfite conversionsequencingwestern blottingrestriction analysis |
| spellingShingle | V. P. Maksimova P. E. Bugaeva E. M. Zhidkova O. G. Usalka E. A. Lesovaya G. A. Belitsky M. G. Yakubovskaya K. I. Kirsanov Modern approaches for the screening of epigenetically active xenobiotics Успехи молекулярной онкологии dna methylation histone acetylation model organisms bisulfite conversion sequencing western blotting restriction analysis |
| title | Modern approaches for the screening of epigenetically active xenobiotics |
| title_full | Modern approaches for the screening of epigenetically active xenobiotics |
| title_fullStr | Modern approaches for the screening of epigenetically active xenobiotics |
| title_full_unstemmed | Modern approaches for the screening of epigenetically active xenobiotics |
| title_short | Modern approaches for the screening of epigenetically active xenobiotics |
| title_sort | modern approaches for the screening of epigenetically active xenobiotics |
| topic | dna methylation histone acetylation model organisms bisulfite conversion sequencing western blotting restriction analysis |
| url | https://umo.abvpress.ru/jour/article/view/229 |
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