Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis
Purpose. The prognostic value of pretreatment lymphocyte monocyte ratio (LMR) in digestive system cancer patients remains controversial. The aim of this study was to quantify the prognostic impact of this biomarker and assess its consistency in digestive system tumors. Methods. We searched “PubMed,”...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/9801063 |
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| _version_ | 1849308971850006528 |
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| author | Jingwen Zhang Lishan Chen Rui Zhou Huiying Sun Yulin Liao Wangjun Liao |
| author_facet | Jingwen Zhang Lishan Chen Rui Zhou Huiying Sun Yulin Liao Wangjun Liao |
| author_sort | Jingwen Zhang |
| collection | DOAJ |
| description | Purpose. The prognostic value of pretreatment lymphocyte monocyte ratio (LMR) in digestive system cancer patients remains controversial. The aim of this study was to quantify the prognostic impact of this biomarker and assess its consistency in digestive system tumors. Methods. We searched “PubMed,” “Embase,” and “CBM” for published eligible studies before June 2016 and conducted a meta-analysis to estimate the pooled hazard ratios (HRs) for disease recurrence and mortality focusing on LMR. Subgroup analyses, meta-regression, and sensitivity analyses were also performed. Results. A total of 22 cohort studies enrolling 12829 patients with digestive system cancer were included. The summary results showed that lower LMR was significantly associated with worse overall survival (OS), cancer-specific survival (CSS), and tumor disease or recurrence-free survival (DFS/RFS) in analyses using the studies reporting HRs either by the univariate analyses (HR = 1.32, HR = 1.35, and HR = 1.26 for OS, CSS, and DFS/RFS, resp.) or by multivariate analyses (HR = 1.21, HR = 1.18, and HR = 1.26 for OS, CSS, and DFS/RFS, resp.). Conclusion. Our results support the fact that decreased LMR indicates worse prognosis in multiple digestive system tumors. |
| format | Article |
| id | doaj-art-0c02c9d1d23b4ea3a2bd154916ce0cea |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-0c02c9d1d23b4ea3a2bd154916ce0cea2025-08-20T03:54:19ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/98010639801063Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-AnalysisJingwen Zhang0Lishan Chen1Rui Zhou2Huiying Sun3Yulin Liao4Wangjun Liao5Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaHuiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaDepartment of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaPurpose. The prognostic value of pretreatment lymphocyte monocyte ratio (LMR) in digestive system cancer patients remains controversial. The aim of this study was to quantify the prognostic impact of this biomarker and assess its consistency in digestive system tumors. Methods. We searched “PubMed,” “Embase,” and “CBM” for published eligible studies before June 2016 and conducted a meta-analysis to estimate the pooled hazard ratios (HRs) for disease recurrence and mortality focusing on LMR. Subgroup analyses, meta-regression, and sensitivity analyses were also performed. Results. A total of 22 cohort studies enrolling 12829 patients with digestive system cancer were included. The summary results showed that lower LMR was significantly associated with worse overall survival (OS), cancer-specific survival (CSS), and tumor disease or recurrence-free survival (DFS/RFS) in analyses using the studies reporting HRs either by the univariate analyses (HR = 1.32, HR = 1.35, and HR = 1.26 for OS, CSS, and DFS/RFS, resp.) or by multivariate analyses (HR = 1.21, HR = 1.18, and HR = 1.26 for OS, CSS, and DFS/RFS, resp.). Conclusion. Our results support the fact that decreased LMR indicates worse prognosis in multiple digestive system tumors.http://dx.doi.org/10.1155/2016/9801063 |
| spellingShingle | Jingwen Zhang Lishan Chen Rui Zhou Huiying Sun Yulin Liao Wangjun Liao Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis Gastroenterology Research and Practice |
| title | Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis |
| title_full | Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis |
| title_fullStr | Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis |
| title_full_unstemmed | Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis |
| title_short | Pretreatment Lymphocyte Monocyte Ratio Predicts Long-Term Outcomes in Patients with Digestive System Tumor: A Meta-Analysis |
| title_sort | pretreatment lymphocyte monocyte ratio predicts long term outcomes in patients with digestive system tumor a meta analysis |
| url | http://dx.doi.org/10.1155/2016/9801063 |
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