Sirt5 affects the metabolic remodeling of eosinophils by negatively regulating the level of succinylation modification of Pkm2 in eosinophilic chronic rhinosinusitis

Sirt5 affects the metabolic remodeling of eosinophils by negatively regulating the level of succinylation modification of Pkm2 in eosinophilic chronic rhinosinusitis

Abstract Objectives This study aims to investigate the role of Sirt5 in regulating eosinophil maturation and activation, specifically focusing on primary eosinophils in mice at the genetic level. Additionally, the study aims to elucidate the underlying mechanism of Sirt5 in eosinophilic inflammation...

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Bibliographic Details
Main Authors: Shun‐Yu Wu, Bo‐Yu Cai, Zhi‐Wen Cao, Tian‐Yu Wang, Cai‐Quan Liang, En‐Hong Xu, Hu Peng, Jianchun‐Liao, Huan‐Hai Liu
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:World Journal of Otorhinolaryngology-Head and Neck Surgery
Subjects:
eosinophilic chronic rhinosinusitis
eosinophils
epigenetics
histone deacetylases
succinylation
Online Access:https://doi.org/10.1002/wjo2.186
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