Synthesis of Spirooxindole-<em>O</em>-Naphthoquinone-Tetrazolo[1,5-<em>a</em>]Pyrimidine Hybrids as Potential Anticancer Agents
A series of novel spirooxindole-<i>O</i>-naphthoquinone-tetrazolo[1,5-<i>a</i>]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These hybrids exhibited relatively high cytotoxic activity against cancer cell line HepG2 (IC<sub>50<...
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MDPI AG
2018-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/23/9/2330 |
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| _version_ | 1846124705822539776 |
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| author | Liqiang Wu Yunxia Liu Yazhen Li |
| author_facet | Liqiang Wu Yunxia Liu Yazhen Li |
| author_sort | Liqiang Wu |
| collection | DOAJ |
| description | A series of novel spirooxindole-<i>O</i>-naphthoquinone-tetrazolo[1,5-<i>a</i>]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These hybrids exhibited relatively high cytotoxic activity against cancer cell line HepG2 (IC<sub>50</sub> = 2.86–36.34 μM), while normal cell line LO2 was less sensitive to these hybrids (IC<sub>50</sub> = 36.37–248.39 μM). On the whole, among all the compounds tested, compound <b>4e</b>, with a mean IC<sub>50</sub> value of 2.86 μM, was the most active. The novel hybrids may find their pharmaceutical applications after further investigations. |
| format | Article |
| id | doaj-art-0bed47455eda41b4a249dda5f0718315 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-0bed47455eda41b4a249dda5f07183152024-12-13T13:30:31ZengMDPI AGMolecules1420-30492018-09-01239233010.3390/molecules23092330molecules23092330Synthesis of Spirooxindole-<em>O</em>-Naphthoquinone-Tetrazolo[1,5-<em>a</em>]Pyrimidine Hybrids as Potential Anticancer AgentsLiqiang Wu0Yunxia Liu1Yazhen Li2School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, ChinaSanQuan Medical College, Xinxiang Medical University, Xinxiang 453003, ChinaSanQuan Medical College, Xinxiang Medical University, Xinxiang 453003, ChinaA series of novel spirooxindole-<i>O</i>-naphthoquinone-tetrazolo[1,5-<i>a</i>]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents. These hybrids exhibited relatively high cytotoxic activity against cancer cell line HepG2 (IC<sub>50</sub> = 2.86–36.34 μM), while normal cell line LO2 was less sensitive to these hybrids (IC<sub>50</sub> = 36.37–248.39 μM). On the whole, among all the compounds tested, compound <b>4e</b>, with a mean IC<sub>50</sub> value of 2.86 μM, was the most active. The novel hybrids may find their pharmaceutical applications after further investigations.https://www.mdpi.com/1420-3049/23/9/2330spirooxindole<i>O</i>-naphthoquinonehybridsantitumor activity |
| spellingShingle | Liqiang Wu Yunxia Liu Yazhen Li Synthesis of Spirooxindole-<em>O</em>-Naphthoquinone-Tetrazolo[1,5-<em>a</em>]Pyrimidine Hybrids as Potential Anticancer Agents Molecules spirooxindole <i>O</i>-naphthoquinone hybrids antitumor activity |
| title | Synthesis of Spirooxindole-<em>O</em>-Naphthoquinone-Tetrazolo[1,5-<em>a</em>]Pyrimidine Hybrids as Potential Anticancer Agents |
| title_full | Synthesis of Spirooxindole-<em>O</em>-Naphthoquinone-Tetrazolo[1,5-<em>a</em>]Pyrimidine Hybrids as Potential Anticancer Agents |
| title_fullStr | Synthesis of Spirooxindole-<em>O</em>-Naphthoquinone-Tetrazolo[1,5-<em>a</em>]Pyrimidine Hybrids as Potential Anticancer Agents |
| title_full_unstemmed | Synthesis of Spirooxindole-<em>O</em>-Naphthoquinone-Tetrazolo[1,5-<em>a</em>]Pyrimidine Hybrids as Potential Anticancer Agents |
| title_short | Synthesis of Spirooxindole-<em>O</em>-Naphthoquinone-Tetrazolo[1,5-<em>a</em>]Pyrimidine Hybrids as Potential Anticancer Agents |
| title_sort | synthesis of spirooxindole em o em naphthoquinone tetrazolo 1 5 em a em pyrimidine hybrids as potential anticancer agents |
| topic | spirooxindole <i>O</i>-naphthoquinone hybrids antitumor activity |
| url | https://www.mdpi.com/1420-3049/23/9/2330 |
| work_keys_str_mv | AT liqiangwu synthesisofspirooxindoleemoemnaphthoquinonetetrazolo15emaempyrimidinehybridsaspotentialanticanceragents AT yunxialiu synthesisofspirooxindoleemoemnaphthoquinonetetrazolo15emaempyrimidinehybridsaspotentialanticanceragents AT yazhenli synthesisofspirooxindoleemoemnaphthoquinonetetrazolo15emaempyrimidinehybridsaspotentialanticanceragents |