Impact of non-steroidal anti-inflammatory drugs exposure on persistent cough after pulmonary resection in a Chinese tertiary hospital: a prospective cohort study protocol
Introduction Previous studies have pointed out that persistent cough is a common complication after pulmonary resection and its occurrence is closely related to inflammatory response. However, there are no clinical studies to date that directly verify that the use of non-steroidal anti-inflammatory...
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BMJ Publishing Group
2025-06-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/6/e096934.full |
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| author | Rong Zhang Xin Zhang Jie Yu Xuan Yang Yi-Fan Zhang Tao He Bo Men Zi-Xiong Nian Xing-Kai Liu Gong-Hao He Wen-Ke Cai |
| author_facet | Rong Zhang Xin Zhang Jie Yu Xuan Yang Yi-Fan Zhang Tao He Bo Men Zi-Xiong Nian Xing-Kai Liu Gong-Hao He Wen-Ke Cai |
| author_sort | Rong Zhang |
| collection | DOAJ |
| description | Introduction Previous studies have pointed out that persistent cough is a common complication after pulmonary resection and its occurrence is closely related to inflammatory response. However, there are no clinical studies to date that directly verify that the use of non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the incidence of persistent cough after pulmonary resection (CAP). In view of this, this study aimed to explore and confirm whether exposure to NSAIDs can effectively reduce the incidence of CAP through a prospective cohort study.Methods and analysis We will conduct a single-centre, prospective cohort comparative study to investigate the impact of NSAIDs use on persistent cough after video-assisted thoracoscopic (VATS) lung resection surgery. The study will include all patients without preoperative cough symptoms who are scheduled for VATS lung resection. These patients will be divided into exposed and non-exposed groups according to whether they used NSAIDs after surgery. The primary outcome measures of this study are the incidence of CAP and the association between NSAIDs exposure and the incidence of CAP in patients undergoing VATS lung resection, while the secondary outcome parameter was set as severity of cough.Ethics and dissemination This research was approved by the Ethics Committee of the 920th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army (2024-041-01). The study findings will be published in peer-reviewed journals and presented at professional conferences.Trial registration number NCT06476249. |
| format | Article |
| id | doaj-art-0bdf57a2e1cf467eaf07d80eb5d3b2d0 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-0bdf57a2e1cf467eaf07d80eb5d3b2d02025-08-20T03:28:13ZengBMJ Publishing GroupBMJ Open2044-60552025-06-0115610.1136/bmjopen-2024-096934Impact of non-steroidal anti-inflammatory drugs exposure on persistent cough after pulmonary resection in a Chinese tertiary hospital: a prospective cohort study protocolRong Zhang0Xin Zhang1Jie Yu2Xuan Yang3Yi-Fan Zhang4Tao He5Bo Men6Zi-Xiong Nian7Xing-Kai Liu8Gong-Hao He9Wen-Ke Cai10Department of Cardiothoracic Vascular Surgery, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Respiratory and Critical Care, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Cardiothoracic Vascular Surgery, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Cardiothoracic Vascular Surgery, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Cardiothoracic Vascular Surgery, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Cardiothoracic Vascular Surgery, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Cardiothoracic Vascular Surgery, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Cardiothoracic Vascular Surgery, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Cardiothoracic Vascular Surgery, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Clinical Pharmacy, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Cardiothoracic Vascular Surgery, Clinical College of the 920th Hospital, Kunming Medical University, Kunming, Yunnan, ChinaIntroduction Previous studies have pointed out that persistent cough is a common complication after pulmonary resection and its occurrence is closely related to inflammatory response. However, there are no clinical studies to date that directly verify that the use of non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the incidence of persistent cough after pulmonary resection (CAP). In view of this, this study aimed to explore and confirm whether exposure to NSAIDs can effectively reduce the incidence of CAP through a prospective cohort study.Methods and analysis We will conduct a single-centre, prospective cohort comparative study to investigate the impact of NSAIDs use on persistent cough after video-assisted thoracoscopic (VATS) lung resection surgery. The study will include all patients without preoperative cough symptoms who are scheduled for VATS lung resection. These patients will be divided into exposed and non-exposed groups according to whether they used NSAIDs after surgery. The primary outcome measures of this study are the incidence of CAP and the association between NSAIDs exposure and the incidence of CAP in patients undergoing VATS lung resection, while the secondary outcome parameter was set as severity of cough.Ethics and dissemination This research was approved by the Ethics Committee of the 920th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army (2024-041-01). The study findings will be published in peer-reviewed journals and presented at professional conferences.Trial registration number NCT06476249.https://bmjopen.bmj.com/content/15/6/e096934.full |
| spellingShingle | Rong Zhang Xin Zhang Jie Yu Xuan Yang Yi-Fan Zhang Tao He Bo Men Zi-Xiong Nian Xing-Kai Liu Gong-Hao He Wen-Ke Cai Impact of non-steroidal anti-inflammatory drugs exposure on persistent cough after pulmonary resection in a Chinese tertiary hospital: a prospective cohort study protocol BMJ Open |
| title | Impact of non-steroidal anti-inflammatory drugs exposure on persistent cough after pulmonary resection in a Chinese tertiary hospital: a prospective cohort study protocol |
| title_full | Impact of non-steroidal anti-inflammatory drugs exposure on persistent cough after pulmonary resection in a Chinese tertiary hospital: a prospective cohort study protocol |
| title_fullStr | Impact of non-steroidal anti-inflammatory drugs exposure on persistent cough after pulmonary resection in a Chinese tertiary hospital: a prospective cohort study protocol |
| title_full_unstemmed | Impact of non-steroidal anti-inflammatory drugs exposure on persistent cough after pulmonary resection in a Chinese tertiary hospital: a prospective cohort study protocol |
| title_short | Impact of non-steroidal anti-inflammatory drugs exposure on persistent cough after pulmonary resection in a Chinese tertiary hospital: a prospective cohort study protocol |
| title_sort | impact of non steroidal anti inflammatory drugs exposure on persistent cough after pulmonary resection in a chinese tertiary hospital a prospective cohort study protocol |
| url | https://bmjopen.bmj.com/content/15/6/e096934.full |
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