Inhibition of Cbl-b restores effector functions of human intratumoral NK cells

Inhibition of Cbl-b restores effector functions of human intratumoral NK cells

Background T cell-based immunotherapies including immune checkpoint blockade and chimeric antigen receptor T cells can induce durable responses in patients with cancer. However, clinical efficacy is limited due to the ability of cancer cells to evade immune surveillance. While T cells have been the...

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Main Authors: Alfred Zippelius, Mélanie Buchi, Petra Herzig, Heinz Läubli, Kirsten D Mertz, Viola Heinzelmann-Schwarz, Didier Lardinois, Marina Natoli, Clara Serger, Alberto Toso, Nicole Brodmann, Sofia Tundo, Marcel Trefny, Andrijana Rodić, Olivia Grueninger, Anastasiya Börsch, Jonas Fürst, Katarzyna Buczak, Alex T Müller, Lisa Sach-Peltason, Leyla Don, Aljaž Hojski, Karin Schaeuble, Thuy T Luu, Andrea Romagnani
Format: Article
Language:English
Published: BMJ Publishing Group 2024-11-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/11/e009860.full
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