Comparative study on the time trends of antimicrobial resistance at animal and human hospitals in a shared community
Antimicrobial resistance (AMR) is a significant global health threat, with increasing morbidity, mortality, and economic consequences. Human and animal health are linked in the spread and evolution of AMR, particularly due to shared antimicrobial usage in healthcare and agriculture. This study inves...
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Elsevier
2025-06-01
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| Series: | One Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352771425001326 |
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| author | Mackenzie Blackstock Jieun Park Matthew Shane Loop Melanie Hyte Andrea Perkins Sarah Grace Gunter Laura Matthews Laura Huber |
| author_facet | Mackenzie Blackstock Jieun Park Matthew Shane Loop Melanie Hyte Andrea Perkins Sarah Grace Gunter Laura Matthews Laura Huber |
| author_sort | Mackenzie Blackstock |
| collection | DOAJ |
| description | Antimicrobial resistance (AMR) is a significant global health threat, with increasing morbidity, mortality, and economic consequences. Human and animal health are linked in the spread and evolution of AMR, particularly due to shared antimicrobial usage in healthcare and agriculture. This study investigates the temporal trends in AMR in both a human and an animal hospital within the same community, focusing on five common drug-bug combinations that overlap between these settings. We aim to explore whether AMR patterns in these two hospitals follow similar trajectories, potentially supporting the hypothesis of cross-species transmission of AMR. Data were retrospectively collected from 2010 to 2022 from East Alabama Medical Center (EAMC) and from 2010 to 2023 from Auburn University Veterinary Teaching Hospital (AUVTH). The analysis focused on Escherichia coli and Klebsiella pneumoniae resistance to cefazolin, ceftriaxone, levofloxacin, and gentamicin, as these were overlapping pairs that had shown statistically significant time trends in preanalysis screening. Bayesian logistic regression was applied to model trends in AMR over time. Generally, the AMR trends in the two hospitals did not align, with decreasing susceptibility in the human hospital and increasing susceptibility in the animal hospital. The trends over time for K. pneumoniae susceptibility to gentamicin were the exception, with both the human and animal hospital showing little change over time. Sensitivity analysis that excluded repeated animal isolates revealed stronger alignment between settings in resistance trends, particularly a decreasing sensitivity over time for E. coli and ceftriaxone. This finding suggests possible shared environmental factors or interspecies transmission in certain instances. This study emphasizes the need to collect combined data from humans and animals to better understand AMR and create joint efforts for antimicrobial stewardship. Further research is needed to clarify the relationship between AMR in these interconnected environments and inform strategies to mitigate the spread of resistance. |
| format | Article |
| id | doaj-art-0bde1e83e03745cf9e33e71de76384cd |
| institution | OA Journals |
| issn | 2352-7714 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | One Health |
| spelling | doaj-art-0bde1e83e03745cf9e33e71de76384cd2025-08-20T02:36:02ZengElsevierOne Health2352-77142025-06-012010109610.1016/j.onehlt.2025.101096Comparative study on the time trends of antimicrobial resistance at animal and human hospitals in a shared communityMackenzie Blackstock0Jieun Park1Matthew Shane Loop2Melanie Hyte3Andrea Perkins4Sarah Grace Gunter5Laura Matthews6Laura Huber7Edward Via College of Osteopathic Medicine - Auburn Campus, 910 S Donahue Dr, Auburn, AL 36832, USADivision of Research, Harrison College of Pharmacy, Auburn University, AL 36849, USADepartment of Health Outcomes Research and Policy, Harrison College of Pharmacy, Auburn University, 362 Thach Concourse, Auburn, AL 36849, USA; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, 301 Pharmacy Ln, Chapel Hill, NC 27516, USAEdward Via College of Osteopathic Medicine - Auburn Campus, 910 S Donahue Dr, Auburn, AL 36832, USADepartment of Clinical Sciences, College of Veterinary Medicine, Auburn University, 1500 Wire Road, Auburn, AL 36832, USADepartment of Pharmacy Services, East Alabama Health, 2000 Pepperell Pkwy, Opelika, AL 36801, USADepartment of Pharmacy Services, East Alabama Health, 2000 Pepperell Pkwy, Opelika, AL 36801, USAPathobiology Department, College of Veterinary Medicine, Auburn University, 1130 Wire Road, Auburn, AL 36832, USA; Corresponding author.Antimicrobial resistance (AMR) is a significant global health threat, with increasing morbidity, mortality, and economic consequences. Human and animal health are linked in the spread and evolution of AMR, particularly due to shared antimicrobial usage in healthcare and agriculture. This study investigates the temporal trends in AMR in both a human and an animal hospital within the same community, focusing on five common drug-bug combinations that overlap between these settings. We aim to explore whether AMR patterns in these two hospitals follow similar trajectories, potentially supporting the hypothesis of cross-species transmission of AMR. Data were retrospectively collected from 2010 to 2022 from East Alabama Medical Center (EAMC) and from 2010 to 2023 from Auburn University Veterinary Teaching Hospital (AUVTH). The analysis focused on Escherichia coli and Klebsiella pneumoniae resistance to cefazolin, ceftriaxone, levofloxacin, and gentamicin, as these were overlapping pairs that had shown statistically significant time trends in preanalysis screening. Bayesian logistic regression was applied to model trends in AMR over time. Generally, the AMR trends in the two hospitals did not align, with decreasing susceptibility in the human hospital and increasing susceptibility in the animal hospital. The trends over time for K. pneumoniae susceptibility to gentamicin were the exception, with both the human and animal hospital showing little change over time. Sensitivity analysis that excluded repeated animal isolates revealed stronger alignment between settings in resistance trends, particularly a decreasing sensitivity over time for E. coli and ceftriaxone. This finding suggests possible shared environmental factors or interspecies transmission in certain instances. This study emphasizes the need to collect combined data from humans and animals to better understand AMR and create joint efforts for antimicrobial stewardship. Further research is needed to clarify the relationship between AMR in these interconnected environments and inform strategies to mitigate the spread of resistance.http://www.sciencedirect.com/science/article/pii/S2352771425001326Antimicrobial resistanceCross-species transmissionShared community |
| spellingShingle | Mackenzie Blackstock Jieun Park Matthew Shane Loop Melanie Hyte Andrea Perkins Sarah Grace Gunter Laura Matthews Laura Huber Comparative study on the time trends of antimicrobial resistance at animal and human hospitals in a shared community One Health Antimicrobial resistance Cross-species transmission Shared community |
| title | Comparative study on the time trends of antimicrobial resistance at animal and human hospitals in a shared community |
| title_full | Comparative study on the time trends of antimicrobial resistance at animal and human hospitals in a shared community |
| title_fullStr | Comparative study on the time trends of antimicrobial resistance at animal and human hospitals in a shared community |
| title_full_unstemmed | Comparative study on the time trends of antimicrobial resistance at animal and human hospitals in a shared community |
| title_short | Comparative study on the time trends of antimicrobial resistance at animal and human hospitals in a shared community |
| title_sort | comparative study on the time trends of antimicrobial resistance at animal and human hospitals in a shared community |
| topic | Antimicrobial resistance Cross-species transmission Shared community |
| url | http://www.sciencedirect.com/science/article/pii/S2352771425001326 |
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