Faecal Carriage of Carbapenem-resistant Enterobacterales in a Tertiary Care Teaching Hospital in Mumbai
CRE colonization can act as a potential source for subsequent infection with high mortality rate. This study was to determine prevalence of faecal carriage of CRE among hospitalized patients and the associated risk factors for acquisition. A prospective cross-sectional study was carried over one yea...
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Journal of Pure and Applied Microbiology
2025-03-01
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| author | Bhagyashree Kadam Priyanka Sheshnath Prasad Gita Nataraj |
| author_facet | Bhagyashree Kadam Priyanka Sheshnath Prasad Gita Nataraj |
| author_sort | Bhagyashree Kadam |
| collection | DOAJ |
| description | CRE colonization can act as a potential source for subsequent infection with high mortality rate. This study was to determine prevalence of faecal carriage of CRE among hospitalized patients and the associated risk factors for acquisition. A prospective cross-sectional study was carried over one year (August 2019-July 2020) on newly admitted indoor patients screened for CRE. Rectal swab/fecal specimen was collected, processed and interpreted as per CLSI standards. Of the 300 patients screened, 331 Enterobacterales were isolated of which 46 CRE strains were detected in 40 patients giving a prevalence 13.3% (40/300). Highest number of CRE were in the age group >60 years while among the CSE-positive patients, highest cases were in the age group 31-40 years. Males (62.5%) had a higher faecal carriage compared to females (37.5%). E. coli and Klebsiella species were predominant in both CRE and CSE groups (63% and 28.3% in CRE; 47.01% and 37.5% in CSE). Among the 46 CRE isolates, 25 (54.3%) were carbapenemase producers, of which 16 (64%) produced metallo-β lactamases. Highest proportion of CRE cases were found among ICU patients (26.82%). Patients harbouring CSE had a mean length of stay (LOS) of 5.2 days while CRE patients had LOS of 15.4 days. On multivariate analysis, risk factors associated with CRE colonization were previous exposure to antibiotics, surgical intervention, and diabetes mellitus. Effective infection control measures, including early detection and isolation of CRE carriers are essential to prevent spread and improve patient outcomes. |
| format | Article |
| id | doaj-art-0bdd1833d9a2473d87cfd33486e40b52 |
| institution | DOAJ |
| issn | 0973-7510 2581-690X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Journal of Pure and Applied Microbiology |
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| series | Journal of Pure and Applied Microbiology |
| spelling | doaj-art-0bdd1833d9a2473d87cfd33486e40b522025-08-20T02:41:20ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2025-03-01191361368https://doi.org/10.22207/JPAM.19.1.26Faecal Carriage of Carbapenem-resistant Enterobacterales in a Tertiary Care Teaching Hospital in MumbaiBhagyashree Kadamhttps://orcid.org/0009-0006-7975-4009Priyanka Sheshnath Prasadhttps://orcid.org/0000-0003-2576-3824Gita NatarajCRE colonization can act as a potential source for subsequent infection with high mortality rate. This study was to determine prevalence of faecal carriage of CRE among hospitalized patients and the associated risk factors for acquisition. A prospective cross-sectional study was carried over one year (August 2019-July 2020) on newly admitted indoor patients screened for CRE. Rectal swab/fecal specimen was collected, processed and interpreted as per CLSI standards. Of the 300 patients screened, 331 Enterobacterales were isolated of which 46 CRE strains were detected in 40 patients giving a prevalence 13.3% (40/300). Highest number of CRE were in the age group >60 years while among the CSE-positive patients, highest cases were in the age group 31-40 years. Males (62.5%) had a higher faecal carriage compared to females (37.5%). E. coli and Klebsiella species were predominant in both CRE and CSE groups (63% and 28.3% in CRE; 47.01% and 37.5% in CSE). Among the 46 CRE isolates, 25 (54.3%) were carbapenemase producers, of which 16 (64%) produced metallo-β lactamases. Highest proportion of CRE cases were found among ICU patients (26.82%). Patients harbouring CSE had a mean length of stay (LOS) of 5.2 days while CRE patients had LOS of 15.4 days. On multivariate analysis, risk factors associated with CRE colonization were previous exposure to antibiotics, surgical intervention, and diabetes mellitus. Effective infection control measures, including early detection and isolation of CRE carriers are essential to prevent spread and improve patient outcomes.https://microbiologyjournal.org/faecal-carriage-of-carbapenem-resistant-enterobacterales-in-a-tertiary-care-teaching-hospital-in-mumbai/carbapenem-resistant enterobacteriaceaecrefecal carriagerisk factorscre colonization |
| spellingShingle | Bhagyashree Kadam Priyanka Sheshnath Prasad Gita Nataraj Faecal Carriage of Carbapenem-resistant Enterobacterales in a Tertiary Care Teaching Hospital in Mumbai Journal of Pure and Applied Microbiology carbapenem-resistant enterobacteriaceae cre fecal carriage risk factors cre colonization |
| title | Faecal Carriage of Carbapenem-resistant Enterobacterales in a Tertiary Care Teaching Hospital in Mumbai |
| title_full | Faecal Carriage of Carbapenem-resistant Enterobacterales in a Tertiary Care Teaching Hospital in Mumbai |
| title_fullStr | Faecal Carriage of Carbapenem-resistant Enterobacterales in a Tertiary Care Teaching Hospital in Mumbai |
| title_full_unstemmed | Faecal Carriage of Carbapenem-resistant Enterobacterales in a Tertiary Care Teaching Hospital in Mumbai |
| title_short | Faecal Carriage of Carbapenem-resistant Enterobacterales in a Tertiary Care Teaching Hospital in Mumbai |
| title_sort | faecal carriage of carbapenem resistant enterobacterales in a tertiary care teaching hospital in mumbai |
| topic | carbapenem-resistant enterobacteriaceae cre fecal carriage risk factors cre colonization |
| url | https://microbiologyjournal.org/faecal-carriage-of-carbapenem-resistant-enterobacterales-in-a-tertiary-care-teaching-hospital-in-mumbai/ |
| work_keys_str_mv | AT bhagyashreekadam faecalcarriageofcarbapenemresistantenterobacteralesinatertiarycareteachinghospitalinmumbai AT priyankasheshnathprasad faecalcarriageofcarbapenemresistantenterobacteralesinatertiarycareteachinghospitalinmumbai AT gitanataraj faecalcarriageofcarbapenemresistantenterobacteralesinatertiarycareteachinghospitalinmumbai |