LANCL1 as the Key Immune Marker in Neuropathic Pain
Objective. This study is to explore key immune markers and changes of immune microenvironment in neuropathic pain (NeuP). Method. The data sets of GSE145199 and GSE145226 in Gene Expression Omnibus (GEO) database was used to analyze, and the key immune markers were verified by GSE70006 and GSE91396,...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2022/9762244 |
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| _version_ | 1832554876389818368 |
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| author | Yu Shi XueFei Zhang Qian Fang Hongrui Zhan Xianglong Wang Xiyan Huang Tao Fan Wei Liu Wen Wu |
| author_facet | Yu Shi XueFei Zhang Qian Fang Hongrui Zhan Xianglong Wang Xiyan Huang Tao Fan Wei Liu Wen Wu |
| author_sort | Yu Shi |
| collection | DOAJ |
| description | Objective. This study is to explore key immune markers and changes of immune microenvironment in neuropathic pain (NeuP). Method. The data sets of GSE145199 and GSE145226 in Gene Expression Omnibus (GEO) database was used to analyze, and the key immune markers were verified by GSE70006 and GSE91396, and the infiltration degree of immune cells in different samples were analyzed by CIBERSORT analysis package. Results. In this study, we found a key immune marker, namely, LANCL1. Regulatory axis closely related to LANCL1 has also been found, namely, miR-6325/LANCL1 axis. In the immune infiltration analysis, we also found that the LANCL1 is positively correlated with T cells CD4 naïve (r=0.880, p<0.05). Conclusion. In this study, we found that LANCL1 may be a protective factor for NeuP, and the miR-6325/LANCL1 axis may be involved in the occurrence and development of NeuP. Cascade reactions including mast cells, macrophages, and T cells may be an important reason for the aggravation of nerve damage. |
| format | Article |
| id | doaj-art-0bdc14fe69b74f7996cbf42f95683b41 |
| institution | Kabale University |
| issn | 1687-5443 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-0bdc14fe69b74f7996cbf42f95683b412025-02-03T05:50:17ZengWileyNeural Plasticity1687-54432022-01-01202210.1155/2022/9762244LANCL1 as the Key Immune Marker in Neuropathic PainYu Shi0XueFei Zhang1Qian Fang2Hongrui Zhan3Xianglong Wang4Xiyan Huang5Tao Fan6Wei Liu7Wen Wu8Department of RehabilitationDepartment of RehabilitationDepartment of RehabilitationDepartment of RehabilitationDepartment of RehabilitationDepartment of RehabilitationDepartment of RehabilitationDepartment of RehabilitationDepartment of RehabilitationObjective. This study is to explore key immune markers and changes of immune microenvironment in neuropathic pain (NeuP). Method. The data sets of GSE145199 and GSE145226 in Gene Expression Omnibus (GEO) database was used to analyze, and the key immune markers were verified by GSE70006 and GSE91396, and the infiltration degree of immune cells in different samples were analyzed by CIBERSORT analysis package. Results. In this study, we found a key immune marker, namely, LANCL1. Regulatory axis closely related to LANCL1 has also been found, namely, miR-6325/LANCL1 axis. In the immune infiltration analysis, we also found that the LANCL1 is positively correlated with T cells CD4 naïve (r=0.880, p<0.05). Conclusion. In this study, we found that LANCL1 may be a protective factor for NeuP, and the miR-6325/LANCL1 axis may be involved in the occurrence and development of NeuP. Cascade reactions including mast cells, macrophages, and T cells may be an important reason for the aggravation of nerve damage.http://dx.doi.org/10.1155/2022/9762244 |
| spellingShingle | Yu Shi XueFei Zhang Qian Fang Hongrui Zhan Xianglong Wang Xiyan Huang Tao Fan Wei Liu Wen Wu LANCL1 as the Key Immune Marker in Neuropathic Pain Neural Plasticity |
| title | LANCL1 as the Key Immune Marker in Neuropathic Pain |
| title_full | LANCL1 as the Key Immune Marker in Neuropathic Pain |
| title_fullStr | LANCL1 as the Key Immune Marker in Neuropathic Pain |
| title_full_unstemmed | LANCL1 as the Key Immune Marker in Neuropathic Pain |
| title_short | LANCL1 as the Key Immune Marker in Neuropathic Pain |
| title_sort | lancl1 as the key immune marker in neuropathic pain |
| url | http://dx.doi.org/10.1155/2022/9762244 |
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