A comprehensive review of oncogenic Notch signaling in multiple myeloma
Multiple myeloma remains an incurable plasma cell cancer with radical case-by-case heterogeneity. Because of this, personalized and disease-specific biology of multiple myeloma must be understood for the discovery of effective molecular targets. The highly evolutionarily conserved Notch signaling pa...
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PeerJ Inc.
2024-11-01
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| Online Access: | https://peerj.com/articles/18485.pdf |
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| author | Justin Roosma |
| author_facet | Justin Roosma |
| author_sort | Justin Roosma |
| collection | DOAJ |
| description | Multiple myeloma remains an incurable plasma cell cancer with radical case-by-case heterogeneity. Because of this, personalized and disease-specific biology of multiple myeloma must be understood for the discovery of effective molecular targets. The highly evolutionarily conserved Notch signaling pathway has been extensively described as a multifaceted driver of the multiple myeloma disease process—contributing to both intrinsic effects of malignant cells and to widespread remodeling of the tumor microenvironment that further facilitates disease progression. Namely, Notch signaling amongst malignant cells promotes increased proliferation, tumor-initiating capacity, drug resistance, and invasiveness. Moreover, Notch signaling between malignant cells and cells of the tumor microenvironment leads to increased osteodegenerative disease and angiogenesis. This comprehensive review will discuss both the intrinsic implications of pathological Notch signaling in multiple myeloma and the extrinsic implications of Notch signaling in the multiple myeloma tumor microenvironment. Additionally, the genetic origins of Notch signaling dysregulation in multiple myeloma and current attempts at targeting Notch therapeutically will be reviewed. While the subject has been reviewed previously, recent developments in the intervening years demand a revised synthesis of the literature. The aim of this work is to introduce and thoroughly synthesize the current state of knowledge in this vein of research and to highlight future directions for both new and in-the-field scientists. |
| format | Article |
| id | doaj-art-0bd247ded2d54c7bb5e8a1dfe523efdf |
| institution | DOAJ |
| issn | 2167-8359 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj-art-0bd247ded2d54c7bb5e8a1dfe523efdf2025-08-20T02:48:42ZengPeerJ Inc.PeerJ2167-83592024-11-0112e1848510.7717/peerj.18485A comprehensive review of oncogenic Notch signaling in multiple myelomaJustin RoosmaMultiple myeloma remains an incurable plasma cell cancer with radical case-by-case heterogeneity. Because of this, personalized and disease-specific biology of multiple myeloma must be understood for the discovery of effective molecular targets. The highly evolutionarily conserved Notch signaling pathway has been extensively described as a multifaceted driver of the multiple myeloma disease process—contributing to both intrinsic effects of malignant cells and to widespread remodeling of the tumor microenvironment that further facilitates disease progression. Namely, Notch signaling amongst malignant cells promotes increased proliferation, tumor-initiating capacity, drug resistance, and invasiveness. Moreover, Notch signaling between malignant cells and cells of the tumor microenvironment leads to increased osteodegenerative disease and angiogenesis. This comprehensive review will discuss both the intrinsic implications of pathological Notch signaling in multiple myeloma and the extrinsic implications of Notch signaling in the multiple myeloma tumor microenvironment. Additionally, the genetic origins of Notch signaling dysregulation in multiple myeloma and current attempts at targeting Notch therapeutically will be reviewed. While the subject has been reviewed previously, recent developments in the intervening years demand a revised synthesis of the literature. The aim of this work is to introduce and thoroughly synthesize the current state of knowledge in this vein of research and to highlight future directions for both new and in-the-field scientists.https://peerj.com/articles/18485.pdfMultiple myelomaNotch signalingTumor microenvironmentPlasma cellsSignal transductionBone marrow metastasis |
| spellingShingle | Justin Roosma A comprehensive review of oncogenic Notch signaling in multiple myeloma PeerJ Multiple myeloma Notch signaling Tumor microenvironment Plasma cells Signal transduction Bone marrow metastasis |
| title | A comprehensive review of oncogenic Notch signaling in multiple myeloma |
| title_full | A comprehensive review of oncogenic Notch signaling in multiple myeloma |
| title_fullStr | A comprehensive review of oncogenic Notch signaling in multiple myeloma |
| title_full_unstemmed | A comprehensive review of oncogenic Notch signaling in multiple myeloma |
| title_short | A comprehensive review of oncogenic Notch signaling in multiple myeloma |
| title_sort | comprehensive review of oncogenic notch signaling in multiple myeloma |
| topic | Multiple myeloma Notch signaling Tumor microenvironment Plasma cells Signal transduction Bone marrow metastasis |
| url | https://peerj.com/articles/18485.pdf |
| work_keys_str_mv | AT justinroosma acomprehensivereviewofoncogenicnotchsignalinginmultiplemyeloma AT justinroosma comprehensivereviewofoncogenicnotchsignalinginmultiplemyeloma |