The Changing Landscape of Antibiotic Treatment: Reevaluating Treatment Length in the Age of New Agents
Background: The landscape of antimicrobial therapy is undergoing a profound transformation; the contemporary arsenal of antimicrobials, particularly those with extended half-lives and enhanced tissue penetration, necessitates critically reassessing these traditional paradigms. The growing emphasis o...
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| Format: | Article |
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MDPI AG
2025-07-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/14/7/727 |
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| author | Francesca Serapide Salvatore Rotundo Luca Gallelli Caterina Palleria Manuela Colosimo Sara Palma Gullì Gianmarco Marcianò Alessandro Russo |
| author_facet | Francesca Serapide Salvatore Rotundo Luca Gallelli Caterina Palleria Manuela Colosimo Sara Palma Gullì Gianmarco Marcianò Alessandro Russo |
| author_sort | Francesca Serapide |
| collection | DOAJ |
| description | Background: The landscape of antimicrobial therapy is undergoing a profound transformation; the contemporary arsenal of antimicrobials, particularly those with extended half-lives and enhanced tissue penetration, necessitates critically reassessing these traditional paradigms. The growing emphasis on antimicrobial stewardship programs has underscored the importance of optimizing antimicrobial agents to minimize the development and spread of resistance. Shorter treatment durations, when clinically appropriate, represent a key strategy in this endeavor. Methods: This narrative review provides a comprehensive synthesis of current evidence on the duration of antimicrobial therapy, with a particular focus on the clinical and pharmacological implications of novel agents, including long-acting formulations. Results: We critically examine the pharmacokinetic and pharmacodynamic properties of these agents, evaluate the opportunities and limitations associated with treatment shortening strategies, and underscore the pivotal role of antimicrobial stewardship in optimizing therapeutic outcomes within an increasingly complex and evolving landscape. Conclusions: The future of antimicrobial therapy lies in a personalized approach, where treatment decisions are tailored to the individual patient, but detailed clinical trials are necessary to evaluate these approaches. |
| format | Article |
| id | doaj-art-0bc9a8ccdaf141b7a2ec80ef234d2b5b |
| institution | DOAJ |
| issn | 2079-6382 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj-art-0bc9a8ccdaf141b7a2ec80ef234d2b5b2025-08-20T03:13:42ZengMDPI AGAntibiotics2079-63822025-07-0114772710.3390/antibiotics14070727The Changing Landscape of Antibiotic Treatment: Reevaluating Treatment Length in the Age of New AgentsFrancesca Serapide0Salvatore Rotundo1Luca Gallelli2Caterina Palleria3Manuela Colosimo4Sara Palma Gullì5Gianmarco Marcianò6Alessandro Russo7Department of Medical and Surgical Sciences, University ‘Magna Graecia’ of Catanzaro, 88100 Catanzaro, ItalyInfectious and Tropical Disease Unit, “Renato Dulbecco” Hospital, 88100 Catanzaro, ItalyDepartment of Health Science, University ‘Magna Graecia’ of Catanzaro, Viale Europa, 88100 Catanzaro, ItalyClinical Pharmacology and Pharmacovigilance Unit, “Renato Dulbecco” University Hospital Viale Europa, 88100 Catanzaro, ItalyMicrobiology and Virology Unit, “Renato Dulbecco” University Hospital, 88100 Catanzaro, ItalyInfectious and Tropical Disease Unit, “Renato Dulbecco” Hospital, 88100 Catanzaro, ItalyClinical Pharmacology and Pharmacovigilance Unit, “Renato Dulbecco” University Hospital Viale Europa, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University ‘Magna Graecia’ of Catanzaro, 88100 Catanzaro, ItalyBackground: The landscape of antimicrobial therapy is undergoing a profound transformation; the contemporary arsenal of antimicrobials, particularly those with extended half-lives and enhanced tissue penetration, necessitates critically reassessing these traditional paradigms. The growing emphasis on antimicrobial stewardship programs has underscored the importance of optimizing antimicrobial agents to minimize the development and spread of resistance. Shorter treatment durations, when clinically appropriate, represent a key strategy in this endeavor. Methods: This narrative review provides a comprehensive synthesis of current evidence on the duration of antimicrobial therapy, with a particular focus on the clinical and pharmacological implications of novel agents, including long-acting formulations. Results: We critically examine the pharmacokinetic and pharmacodynamic properties of these agents, evaluate the opportunities and limitations associated with treatment shortening strategies, and underscore the pivotal role of antimicrobial stewardship in optimizing therapeutic outcomes within an increasingly complex and evolving landscape. Conclusions: The future of antimicrobial therapy lies in a personalized approach, where treatment decisions are tailored to the individual patient, but detailed clinical trials are necessary to evaluate these approaches.https://www.mdpi.com/2079-6382/14/7/727antibioticspharmacokineticpharmacodynamichalf-liferesistance |
| spellingShingle | Francesca Serapide Salvatore Rotundo Luca Gallelli Caterina Palleria Manuela Colosimo Sara Palma Gullì Gianmarco Marcianò Alessandro Russo The Changing Landscape of Antibiotic Treatment: Reevaluating Treatment Length in the Age of New Agents Antibiotics antibiotics pharmacokinetic pharmacodynamic half-life resistance |
| title | The Changing Landscape of Antibiotic Treatment: Reevaluating Treatment Length in the Age of New Agents |
| title_full | The Changing Landscape of Antibiotic Treatment: Reevaluating Treatment Length in the Age of New Agents |
| title_fullStr | The Changing Landscape of Antibiotic Treatment: Reevaluating Treatment Length in the Age of New Agents |
| title_full_unstemmed | The Changing Landscape of Antibiotic Treatment: Reevaluating Treatment Length in the Age of New Agents |
| title_short | The Changing Landscape of Antibiotic Treatment: Reevaluating Treatment Length in the Age of New Agents |
| title_sort | changing landscape of antibiotic treatment reevaluating treatment length in the age of new agents |
| topic | antibiotics pharmacokinetic pharmacodynamic half-life resistance |
| url | https://www.mdpi.com/2079-6382/14/7/727 |
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