Oxidative stress and antioxidant status among the elderly in Jakarta
Background: Indonesia is experiencing a demographic shift, with the elderly population comprising 9.92% (26.82 million) of the total population, 8.21% of whom reside in Jakarta. Oxidative stress is a key contributor to the development of degenerative diseases associated with aging, while antioxidan...
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Indonesian Society for Biochemistry and Molecular Biology
2024-10-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/177 |
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| author | Novi Silvia Hardiany Daniya Qanita Amani Jasmine Virginia Anjani Prima Christin Natalia Rheina Tamara Tarigan |
| author_facet | Novi Silvia Hardiany Daniya Qanita Amani Jasmine Virginia Anjani Prima Christin Natalia Rheina Tamara Tarigan |
| author_sort | Novi Silvia Hardiany |
| collection | DOAJ |
| description |
Background: Indonesia is experiencing a demographic shift, with the elderly population comprising 9.92% (26.82 million) of the total population, 8.21% of whom reside in Jakarta. Oxidative stress is a key contributor to the development of degenerative diseases associated with aging, while antioxidant defenses can mitigate its effects.
Objective: This study aimed to assess oxidative stress levels, measured by malondialdehyde (MDA), and antioxidant status, including catalase, reduced glutathione (GSH), and vitamin C, in the elderly population of Jakarta.
Methods: A cross-sectional study was conducted with 91 elderly participants from three sub-districts in Jakarta. Erythrocyte lysate samples were analyzed to measure MDA, catalase, and GSH levels, while plasma was used to measure vitamin C. All parameters were quantified using a spectrophotometer. MDA levels and antioxidant status were categorized based on age, blood pressure, and the number of chronic diseases, with statistical analysis performed using the Kruskal-Wallis test.
Results: The median MDA level was 2.68 (1.61–5.64) nmol/mL, with the highest levels observed in participants aged 60–64 and those with three chronic diseases. The mean catalase level was 2.41 ± 0.39 U/mL, the median GSH level was 6.16 (2.02–128.07) µmol/mL, and the mean vitamin C level was 10.87 ± 4.9 µg/mL. No significant differences in antioxidant status were observed based on age, blood pressure, or the number of chronic diseases.
Conclusion: Oxidative stress is prevalent in the elderly and is particularly influenced by the presence of multiple chronic diseases. However, antioxidant status does not significantly vary with age, blood pressure, or disease burden in this population.
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| format | Article |
| id | doaj-art-0bc777bba0bb4cfca2189496c5be2dc0 |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-0bc777bba0bb4cfca2189496c5be2dc02025-02-08T03:04:43ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222024-10-017210.32889/actabioina.177Oxidative stress and antioxidant status among the elderly in JakartaNovi Silvia Hardiany0Daniya Qanita Amani1Jasmine Virginia Anjani2Prima Christin Natalia3Rheina Tamara Tarigan4Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaUndergraduate Program in Medical Science Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaUndergraduate Program in Medical Science Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaUndergraduate Program in Medical Science Faculty of Medicine, Universitas Indonesia, Jakarta 10430, IndonesiaUndergraduate Program in Medical Science Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia Background: Indonesia is experiencing a demographic shift, with the elderly population comprising 9.92% (26.82 million) of the total population, 8.21% of whom reside in Jakarta. Oxidative stress is a key contributor to the development of degenerative diseases associated with aging, while antioxidant defenses can mitigate its effects. Objective: This study aimed to assess oxidative stress levels, measured by malondialdehyde (MDA), and antioxidant status, including catalase, reduced glutathione (GSH), and vitamin C, in the elderly population of Jakarta. Methods: A cross-sectional study was conducted with 91 elderly participants from three sub-districts in Jakarta. Erythrocyte lysate samples were analyzed to measure MDA, catalase, and GSH levels, while plasma was used to measure vitamin C. All parameters were quantified using a spectrophotometer. MDA levels and antioxidant status were categorized based on age, blood pressure, and the number of chronic diseases, with statistical analysis performed using the Kruskal-Wallis test. Results: The median MDA level was 2.68 (1.61–5.64) nmol/mL, with the highest levels observed in participants aged 60–64 and those with three chronic diseases. The mean catalase level was 2.41 ± 0.39 U/mL, the median GSH level was 6.16 (2.02–128.07) µmol/mL, and the mean vitamin C level was 10.87 ± 4.9 µg/mL. No significant differences in antioxidant status were observed based on age, blood pressure, or the number of chronic diseases. Conclusion: Oxidative stress is prevalent in the elderly and is particularly influenced by the presence of multiple chronic diseases. However, antioxidant status does not significantly vary with age, blood pressure, or disease burden in this population. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/177oxidative stressantioxidantelderly |
| spellingShingle | Novi Silvia Hardiany Daniya Qanita Amani Jasmine Virginia Anjani Prima Christin Natalia Rheina Tamara Tarigan Oxidative stress and antioxidant status among the elderly in Jakarta Acta Biochimica Indonesiana oxidative stress antioxidant elderly |
| title | Oxidative stress and antioxidant status among the elderly in Jakarta |
| title_full | Oxidative stress and antioxidant status among the elderly in Jakarta |
| title_fullStr | Oxidative stress and antioxidant status among the elderly in Jakarta |
| title_full_unstemmed | Oxidative stress and antioxidant status among the elderly in Jakarta |
| title_short | Oxidative stress and antioxidant status among the elderly in Jakarta |
| title_sort | oxidative stress and antioxidant status among the elderly in jakarta |
| topic | oxidative stress antioxidant elderly |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/177 |
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