Microbiota‐Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration

Microbiota‐Derived Inosine Suppresses Systemic Autoimmunity via Restriction of B Cell Differentiation and Migration

Abstract The role of gut microbiota dysbiosis in systemic lupus erythematosus (SLE) pathogenesis remains elusive. Here, it is shown that fecal microbiota transplantation (FMT) from healthy mice to lupus mice ameliorates lupus‐like symptoms. Microbiota reconstitution effectively reduces systemic clas...

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Main Authors: Lingyu Gao, Yuhan Zhang, Zhi Hu, Shengwen Chen, Qiaolin Wang, Yong Zeng, Huiqi Yin, Junpeng Zhao, Yijing Zhan, Changxing Gao, Yue Xin, Bing Chen, Stijn van derVeen, Ming Zhao, Deyu Fang, Qianjin Lu
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
systemic lupus erythematosus (SLE)
lupus nephritis (LN)
fecal microbiota transplantation (FMT)
Lactobacillus johnsonii
purine metabolites
inosine
Online Access:https://doi.org/10.1002/advs.202409837
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