Impact of targeting the platelet-activating factor and its receptor in cancer treatment
Abstract The lipid mediator platelet-activating factor (PAF) and its receptor (PAFR) signaling play critical roles in a wide range of physiological and pathophysiological conditions, including cancer growth and metastasis. The ability of PAFR to interact with other oncogenic signaling cascades makes...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Military Medical Research |
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| Online Access: | https://doi.org/10.1186/s40779-025-00597-0 |
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| author | Kimya Qaderi Arvin Shahmoradi Anita Thyagarajan Ravi P. Sahu |
| author_facet | Kimya Qaderi Arvin Shahmoradi Anita Thyagarajan Ravi P. Sahu |
| author_sort | Kimya Qaderi |
| collection | DOAJ |
| description | Abstract The lipid mediator platelet-activating factor (PAF) and its receptor (PAFR) signaling play critical roles in a wide range of physiological and pathophysiological conditions, including cancer growth and metastasis. The ability of PAFR to interact with other oncogenic signaling cascades makes it a promising target for cancer treatment. Moreover, numerous natural and synthetic compounds, characterized by diverse pharmacological activities such as anti-inflammatory and anti-tumor effects, have been explored for their potential as PAF and PAFR antagonists. In this review, we provide comprehensive evidence regarding the PAF/PAFR signaling pathway, highlighting the effectiveness of various classes of PAF and PAFR inhibitors and antagonists across multiple cancer models. Notably, the synergistic effects of PAF and PAFR antagonists in enhancing the efficacy of chemotherapy and radiation therapy in several experimental cancer models are also discussed. Overall, the synthesis of literature review indicates that targeting the PAF/PAFR axis represents a promising approach for cancer treatment and also exerts synergy with chemotherapy and radiation therapy. |
| format | Article |
| id | doaj-art-0bc279c232164db5905a50975587efed |
| institution | DOAJ |
| issn | 2054-9369 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Military Medical Research |
| spelling | doaj-art-0bc279c232164db5905a50975587efed2025-08-20T02:59:19ZengBMCMilitary Medical Research2054-93692025-03-0112112710.1186/s40779-025-00597-0Impact of targeting the platelet-activating factor and its receptor in cancer treatmentKimya Qaderi0Arvin Shahmoradi1Anita Thyagarajan2Ravi P. Sahu3Department of Molecular and Cell Biology, College of Life Sciences, University of LeicesterDepartment of Laboratory Medicine, Faculty of Paramedical, Kurdistan University of Medical SciencesDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine Wright State UniversityDepartment of Pharmacology and Toxicology, Boonshoft School of Medicine Wright State UniversityAbstract The lipid mediator platelet-activating factor (PAF) and its receptor (PAFR) signaling play critical roles in a wide range of physiological and pathophysiological conditions, including cancer growth and metastasis. The ability of PAFR to interact with other oncogenic signaling cascades makes it a promising target for cancer treatment. Moreover, numerous natural and synthetic compounds, characterized by diverse pharmacological activities such as anti-inflammatory and anti-tumor effects, have been explored for their potential as PAF and PAFR antagonists. In this review, we provide comprehensive evidence regarding the PAF/PAFR signaling pathway, highlighting the effectiveness of various classes of PAF and PAFR inhibitors and antagonists across multiple cancer models. Notably, the synergistic effects of PAF and PAFR antagonists in enhancing the efficacy of chemotherapy and radiation therapy in several experimental cancer models are also discussed. Overall, the synthesis of literature review indicates that targeting the PAF/PAFR axis represents a promising approach for cancer treatment and also exerts synergy with chemotherapy and radiation therapy.https://doi.org/10.1186/s40779-025-00597-0Platelet-activating factor (PAF)Platelet-activating factor-receptor (PAFR)AntagonistsInhibitorsCancerCell signaling pathways |
| spellingShingle | Kimya Qaderi Arvin Shahmoradi Anita Thyagarajan Ravi P. Sahu Impact of targeting the platelet-activating factor and its receptor in cancer treatment Military Medical Research Platelet-activating factor (PAF) Platelet-activating factor-receptor (PAFR) Antagonists Inhibitors Cancer Cell signaling pathways |
| title | Impact of targeting the platelet-activating factor and its receptor in cancer treatment |
| title_full | Impact of targeting the platelet-activating factor and its receptor in cancer treatment |
| title_fullStr | Impact of targeting the platelet-activating factor and its receptor in cancer treatment |
| title_full_unstemmed | Impact of targeting the platelet-activating factor and its receptor in cancer treatment |
| title_short | Impact of targeting the platelet-activating factor and its receptor in cancer treatment |
| title_sort | impact of targeting the platelet activating factor and its receptor in cancer treatment |
| topic | Platelet-activating factor (PAF) Platelet-activating factor-receptor (PAFR) Antagonists Inhibitors Cancer Cell signaling pathways |
| url | https://doi.org/10.1186/s40779-025-00597-0 |
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