Correlation between suboptimal vitamin D concentration and secondary hyperparathyroidism in women with low-energy fracture
Background/Aim. Osteoporosis is the most common metabolic bone disorder worldwide characterized by decreased bone strength that predisposes to an increased fracture risk, especially in postmenopausal women. Today, over 25 million people, mainly women, suffer from this metabolic disorder. In addition...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2021-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900054C.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850245209508544512 |
|---|---|
| author | Ćirković Milan Božić Ksenija Petronijević Nataša Nikolić Tatjana |
| author_facet | Ćirković Milan Božić Ksenija Petronijević Nataša Nikolić Tatjana |
| author_sort | Ćirković Milan |
| collection | DOAJ |
| description | Background/Aim. Osteoporosis is the most common metabolic bone disorder worldwide characterized by decreased bone strength that predisposes to an increased fracture risk, especially in postmenopausal women. Today, over 25 million people, mainly women, suffer from this metabolic disorder. In addition to genetic predispositions, hormonal disorders, lifestyle, and insufficient vitamin D levels in the blood are significant risk factors for the occurrence of osteoporosis and low-energy fractures. The aim of our study was to analyze the incidence of osteoporosis and the correlation between vitamin D deficiency and secondary hyperparathyroidism in women of different ages with low-energy fractures. Methods. This cross-sectional study included 559 women who were not previously treated for osteoporosis. All women were clinically examined and their anamnesis of chronic illnesses, fractures, and therapies was taken. Height and weight were measured, and body mass index (BMI) was calculated. Risk factors for osteoporosis, including the concentration of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH), were measured. Vitamin D deficiency was defined as serum level of 25(OH)D less than 30 ng/mL (75 nmol/L). Results. The study included a total of 559 women, of which low-energy fractures were identified in 102 women. Women with fractures were older (63.69 ± 13.88 years) compared to women without fractures (54.39 ± 14.10 years) (p < 0.0005). Furthermore, BMI was also higher (27.75 kg/m2) in women with fractures compared to the other group (26.49 kg/m2) (p < 0.025). Out of 102 women with fractures, 88 were postmenopausal. The most frequent fractures were the humerus and radius fractures, 11.62% (65/559), followed by femoral neck fractures, 7.15% (40/559), and body vertebrae fractures, 3.04% (17/559). A significant decrease of the bone mineral density (BMD) in the spinal and the femoral neck sites was observed in women with femoral neck and body vertebrae fractures, but not in women with humerus and radius fractures. Vitamin D deficiency did not have a significant impact on fracture incidence. The increased concentration of PTH was statistically significant in women with femoral neck and body vertebrae fractures. Conclusion. In women with all three types of low-energy fractures, compared to women without fractures, significant risk factors for osteoporosis were age, BMD, and the strength of mechanical force during fall (estimated through BMI). |
| format | Article |
| id | doaj-art-0bbf29ea2b294b9baec8ea74e3fca82e |
| institution | OA Journals |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-0bbf29ea2b294b9baec8ea74e3fca82e2025-08-20T01:59:31ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202021-01-0178218619110.2298/VSP190208054C0042-84501900054CCorrelation between suboptimal vitamin D concentration and secondary hyperparathyroidism in women with low-energy fractureĆirković Milan0Božić Ksenija1Petronijević Nataša2https://orcid.org/0000-0002-4338-1953Nikolić Tatjana3Military Medical Academy, Clinic for Rheumatology, Belgrade, SerbiaMilitary Medical Academy, Clinic for Rheumatology, Belgrade, Serbia + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade, SerbiaClinical Centre of Serbia, Institute for Biochemistry, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaClinical Centre of Serbia, Institute for Biochemistry, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaBackground/Aim. Osteoporosis is the most common metabolic bone disorder worldwide characterized by decreased bone strength that predisposes to an increased fracture risk, especially in postmenopausal women. Today, over 25 million people, mainly women, suffer from this metabolic disorder. In addition to genetic predispositions, hormonal disorders, lifestyle, and insufficient vitamin D levels in the blood are significant risk factors for the occurrence of osteoporosis and low-energy fractures. The aim of our study was to analyze the incidence of osteoporosis and the correlation between vitamin D deficiency and secondary hyperparathyroidism in women of different ages with low-energy fractures. Methods. This cross-sectional study included 559 women who were not previously treated for osteoporosis. All women were clinically examined and their anamnesis of chronic illnesses, fractures, and therapies was taken. Height and weight were measured, and body mass index (BMI) was calculated. Risk factors for osteoporosis, including the concentration of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH), were measured. Vitamin D deficiency was defined as serum level of 25(OH)D less than 30 ng/mL (75 nmol/L). Results. The study included a total of 559 women, of which low-energy fractures were identified in 102 women. Women with fractures were older (63.69 ± 13.88 years) compared to women without fractures (54.39 ± 14.10 years) (p < 0.0005). Furthermore, BMI was also higher (27.75 kg/m2) in women with fractures compared to the other group (26.49 kg/m2) (p < 0.025). Out of 102 women with fractures, 88 were postmenopausal. The most frequent fractures were the humerus and radius fractures, 11.62% (65/559), followed by femoral neck fractures, 7.15% (40/559), and body vertebrae fractures, 3.04% (17/559). A significant decrease of the bone mineral density (BMD) in the spinal and the femoral neck sites was observed in women with femoral neck and body vertebrae fractures, but not in women with humerus and radius fractures. Vitamin D deficiency did not have a significant impact on fracture incidence. The increased concentration of PTH was statistically significant in women with femoral neck and body vertebrae fractures. Conclusion. In women with all three types of low-energy fractures, compared to women without fractures, significant risk factors for osteoporosis were age, BMD, and the strength of mechanical force during fall (estimated through BMI).http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900054C.pdfosteoporosisrisk factorsvitamin dfractures, bonehyperparathyroidism, secondarywomen |
| spellingShingle | Ćirković Milan Božić Ksenija Petronijević Nataša Nikolić Tatjana Correlation between suboptimal vitamin D concentration and secondary hyperparathyroidism in women with low-energy fracture Vojnosanitetski Pregled osteoporosis risk factors vitamin d fractures, bone hyperparathyroidism, secondary women |
| title | Correlation between suboptimal vitamin D concentration and secondary hyperparathyroidism in women with low-energy fracture |
| title_full | Correlation between suboptimal vitamin D concentration and secondary hyperparathyroidism in women with low-energy fracture |
| title_fullStr | Correlation between suboptimal vitamin D concentration and secondary hyperparathyroidism in women with low-energy fracture |
| title_full_unstemmed | Correlation between suboptimal vitamin D concentration and secondary hyperparathyroidism in women with low-energy fracture |
| title_short | Correlation between suboptimal vitamin D concentration and secondary hyperparathyroidism in women with low-energy fracture |
| title_sort | correlation between suboptimal vitamin d concentration and secondary hyperparathyroidism in women with low energy fracture |
| topic | osteoporosis risk factors vitamin d fractures, bone hyperparathyroidism, secondary women |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84501900054C.pdf |
| work_keys_str_mv | AT cirkovicmilan correlationbetweensuboptimalvitamindconcentrationandsecondaryhyperparathyroidisminwomenwithlowenergyfracture AT bozicksenija correlationbetweensuboptimalvitamindconcentrationandsecondaryhyperparathyroidisminwomenwithlowenergyfracture AT petronijevicnatasa correlationbetweensuboptimalvitamindconcentrationandsecondaryhyperparathyroidisminwomenwithlowenergyfracture AT nikolictatjana correlationbetweensuboptimalvitamindconcentrationandsecondaryhyperparathyroidisminwomenwithlowenergyfracture |