Gorlin-Goltz syndrome in an older black adult. Case Report
Introduction: Gorlin-Goltz syndrome (GGS), or basal cell nevus syndrome (BCNS), is a rare genetic disease that induces the development of odontogenic keratocysts, skeletal malformations and neoplasms, especially multiple and recurrent basal cell carcinomas (BCC). This condition is rare in black peo...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidad Nacional de Colombia
2021-04-01
|
| Series: | Revista de la Facultad de Medicina |
| Subjects: | |
| Online Access: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/83066 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849699025086840832 |
|---|---|
| author | Mauricio Andrés Uribe-Valencia Janeth Jurado-Delgado Lina Marcela Velásquez-Tafur Luis Fernando Cárdenas-Cardona |
| author_facet | Mauricio Andrés Uribe-Valencia Janeth Jurado-Delgado Lina Marcela Velásquez-Tafur Luis Fernando Cárdenas-Cardona |
| author_sort | Mauricio Andrés Uribe-Valencia |
| collection | DOAJ |
| description |
Introduction: Gorlin-Goltz syndrome (GGS), or basal cell nevus syndrome (BCNS), is a rare genetic disease that induces the development of odontogenic keratocysts, skeletal malformations and neoplasms, especially multiple and recurrent basal cell carcinomas (BCC). This condition is rare in black people, being reported in this population in only 5% of the cases.
Case presentation: A 68-year-old black man reported the constant appearance for approximately 4 years of multiple papules and non-pruritic and non-desquamating skin plaques, with hyperpigmented margins, of different sizes that grew gradually in scalp, left lower eyelid, arms, forearms, back, and lower limbs. Histopathological study showed multiple BCC, and imaging studies identified calcifications in the tentorium cerebelli and cerebral falx, as well as images suggestive of odontogenic cysts. Based on his clinical history, histopathologic and imaging findings, and physical examination, he was diagnosed with GGS.
Conclusions: This is the first case of GGS in an older black adult reported in Colombia. This case highlights the relevance of reviewing the medical records and performing a thorough physical examination when approaching the patient, as well as doing a comprehensive geriatric assessment, since they are key to diagnose this rare disease and initiate a timely multidisciplinary treatment. This will allow obtaining better outcomes in these patients.
|
| format | Article |
| id | doaj-art-0bbdccb958b14fa9a61d2e296c85163d |
| institution | DOAJ |
| issn | 0120-0011 2357-3848 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Revista de la Facultad de Medicina |
| spelling | doaj-art-0bbdccb958b14fa9a61d2e296c85163d2025-08-20T03:18:43ZengUniversidad Nacional de ColombiaRevista de la Facultad de Medicina0120-00112357-38482021-04-0169210.15446/revfacmed.v69n2.83066Gorlin-Goltz syndrome in an older black adult. Case ReportMauricio Andrés Uribe-Valencia0https://orcid.org/0000-0002-0065-6152Janeth Jurado-Delgado1https://orcid.org/0000-0002-0305-1714Lina Marcela Velásquez-Tafur2https://orcid.org/0000-0003-4418-7092Luis Fernando Cárdenas-Cardona3https://orcid.org/0000-0002-7244-6234Universidad del Valle - Faculty of Health - Geriatrics Program - Cali - Colombia.Universidad del Valle - Faculty of Health - Geriatrics Program - Cali - Colombia.Universidad del Valle - Faculty of Health - Department of Internal Medicine - Dermatology and Dermatological Surgery Section - Cali - Colombia.Universidad del Valle - Faculty of Health - Department of Internal Medicine - Dermatology and Dermatological Surgery Section - Cali - Colombia. Introduction: Gorlin-Goltz syndrome (GGS), or basal cell nevus syndrome (BCNS), is a rare genetic disease that induces the development of odontogenic keratocysts, skeletal malformations and neoplasms, especially multiple and recurrent basal cell carcinomas (BCC). This condition is rare in black people, being reported in this population in only 5% of the cases. Case presentation: A 68-year-old black man reported the constant appearance for approximately 4 years of multiple papules and non-pruritic and non-desquamating skin plaques, with hyperpigmented margins, of different sizes that grew gradually in scalp, left lower eyelid, arms, forearms, back, and lower limbs. Histopathological study showed multiple BCC, and imaging studies identified calcifications in the tentorium cerebelli and cerebral falx, as well as images suggestive of odontogenic cysts. Based on his clinical history, histopathologic and imaging findings, and physical examination, he was diagnosed with GGS. Conclusions: This is the first case of GGS in an older black adult reported in Colombia. This case highlights the relevance of reviewing the medical records and performing a thorough physical examination when approaching the patient, as well as doing a comprehensive geriatric assessment, since they are key to diagnose this rare disease and initiate a timely multidisciplinary treatment. This will allow obtaining better outcomes in these patients. https://revistas.unal.edu.co/index.php/revfacmed/article/view/83066Basal Cell CarcinomaGorlin-Goltz SyndromeBasal cell Nevus SyndromeElderly |
| spellingShingle | Mauricio Andrés Uribe-Valencia Janeth Jurado-Delgado Lina Marcela Velásquez-Tafur Luis Fernando Cárdenas-Cardona Gorlin-Goltz syndrome in an older black adult. Case Report Revista de la Facultad de Medicina Basal Cell Carcinoma Gorlin-Goltz Syndrome Basal cell Nevus Syndrome Elderly |
| title | Gorlin-Goltz syndrome in an older black adult. Case Report |
| title_full | Gorlin-Goltz syndrome in an older black adult. Case Report |
| title_fullStr | Gorlin-Goltz syndrome in an older black adult. Case Report |
| title_full_unstemmed | Gorlin-Goltz syndrome in an older black adult. Case Report |
| title_short | Gorlin-Goltz syndrome in an older black adult. Case Report |
| title_sort | gorlin goltz syndrome in an older black adult case report |
| topic | Basal Cell Carcinoma Gorlin-Goltz Syndrome Basal cell Nevus Syndrome Elderly |
| url | https://revistas.unal.edu.co/index.php/revfacmed/article/view/83066 |
| work_keys_str_mv | AT mauricioandresuribevalencia gorlingoltzsyndromeinanolderblackadultcasereport AT janethjuradodelgado gorlingoltzsyndromeinanolderblackadultcasereport AT linamarcelavelasqueztafur gorlingoltzsyndromeinanolderblackadultcasereport AT luisfernandocardenascardona gorlingoltzsyndromeinanolderblackadultcasereport |