Italian screening protocol and genotypes characterization for HCV elimination (2022–2023) in Ferrara’s province: a real-world study
Abstract Hepatitis C virus (HCV) is a worldwide health hazard, and in chronic form (nowadays affecting 50 million people – World Health Organization data) can be lethal. To forestall it, preventive screening is a mandatory approach. Since 2021, Italy conducts a national-wide screening program to eli...
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Nature Portfolio
2025-03-01
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| author | Nicolò Landini Chiara Chiericati Michela Boni Loredana Simone Massimo Trombini Chiara Zanforlin Caterina Palmonari |
| author_facet | Nicolò Landini Chiara Chiericati Michela Boni Loredana Simone Massimo Trombini Chiara Zanforlin Caterina Palmonari |
| author_sort | Nicolò Landini |
| collection | DOAJ |
| description | Abstract Hepatitis C virus (HCV) is a worldwide health hazard, and in chronic form (nowadays affecting 50 million people – World Health Organization data) can be lethal. To forestall it, preventive screening is a mandatory approach. Since 2021, Italy conducts a national-wide screening program to eliminate the virus from its population. The team perfected an innovative method throughout the period between 2022 and 2023, to answer that medical necessity and map HCV genotypes. The medical protocol has introduced a dedicated double invitation model for the adherents, with consequential pre-prepared medical consumables allocated. The population was divided in three separate groups: born between 1969 and 1989, addiction services, and prison. Two screening levels were carried out: anti-HCV antibodies (indirect chemiluminescence immunoassay) and quantitative HCV RNA reverse transcription. 51,283 adherents were registered: 447 resulted positive to the first screening round, and 88 to the second (393 and 77 patients respectively from population born between 1969 and 1989). The medical protocol introduced allowed to substantially increase patients and medical staff compliance to HCV screening (adherence: 51.83%, the highest in Italy). HCV genotypes’ distribution was mapped by patients’ age, biological sex and origin over five groups comprehending subtypes 1a(35.06% of the positive population), 1b(27.27%), 2a/2c(10.39%), 3a(22.08%), 4a/4c/4d(5.19%). |
| format | Article |
| id | doaj-art-0bb9aa1bcf3e4c5d90612fccd4f20070 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-0bb9aa1bcf3e4c5d90612fccd4f200702025-08-20T03:05:56ZengNature PortfolioScientific Reports2045-23222025-03-0115111310.1038/s41598-025-92654-wItalian screening protocol and genotypes characterization for HCV elimination (2022–2023) in Ferrara’s province: a real-world studyNicolò Landini0Chiara Chiericati1Michela Boni2Loredana Simone3Massimo Trombini4Chiara Zanforlin5Caterina Palmonari6AUSL – U.O.S.D. Oncology Screenings, Epidemiology and Health Promotion Programs, Local Health Agency of FerraraAUSL – U.O.S.D. Oncology Screenings, Epidemiology and Health Promotion Programs, Local Health Agency of FerraraChemical-Clinical Analysis Laboratory, S. Anna University HospitalDepartment of Gastroenterology and Gastrointestinal Endoscopy, S. Anna University HospitalAUSL – Addiction Service, Local Health Agency of RomagnaAUSL – U.O.S.D. Oncology Screenings, Epidemiology and Health Promotion Programs, Local Health Agency of FerraraAUSL – U.O.S.D. Oncology Screenings, Epidemiology and Health Promotion Programs, Local Health Agency of FerraraAbstract Hepatitis C virus (HCV) is a worldwide health hazard, and in chronic form (nowadays affecting 50 million people – World Health Organization data) can be lethal. To forestall it, preventive screening is a mandatory approach. Since 2021, Italy conducts a national-wide screening program to eliminate the virus from its population. The team perfected an innovative method throughout the period between 2022 and 2023, to answer that medical necessity and map HCV genotypes. The medical protocol has introduced a dedicated double invitation model for the adherents, with consequential pre-prepared medical consumables allocated. The population was divided in three separate groups: born between 1969 and 1989, addiction services, and prison. Two screening levels were carried out: anti-HCV antibodies (indirect chemiluminescence immunoassay) and quantitative HCV RNA reverse transcription. 51,283 adherents were registered: 447 resulted positive to the first screening round, and 88 to the second (393 and 77 patients respectively from population born between 1969 and 1989). The medical protocol introduced allowed to substantially increase patients and medical staff compliance to HCV screening (adherence: 51.83%, the highest in Italy). HCV genotypes’ distribution was mapped by patients’ age, biological sex and origin over five groups comprehending subtypes 1a(35.06% of the positive population), 1b(27.27%), 2a/2c(10.39%), 3a(22.08%), 4a/4c/4d(5.19%).https://doi.org/10.1038/s41598-025-92654-wHepatitis CPopulation screeningViral genotypesPolymerase chain reactionPreventionHealth system |
| spellingShingle | Nicolò Landini Chiara Chiericati Michela Boni Loredana Simone Massimo Trombini Chiara Zanforlin Caterina Palmonari Italian screening protocol and genotypes characterization for HCV elimination (2022–2023) in Ferrara’s province: a real-world study Scientific Reports Hepatitis C Population screening Viral genotypes Polymerase chain reaction Prevention Health system |
| title | Italian screening protocol and genotypes characterization for HCV elimination (2022–2023) in Ferrara’s province: a real-world study |
| title_full | Italian screening protocol and genotypes characterization for HCV elimination (2022–2023) in Ferrara’s province: a real-world study |
| title_fullStr | Italian screening protocol and genotypes characterization for HCV elimination (2022–2023) in Ferrara’s province: a real-world study |
| title_full_unstemmed | Italian screening protocol and genotypes characterization for HCV elimination (2022–2023) in Ferrara’s province: a real-world study |
| title_short | Italian screening protocol and genotypes characterization for HCV elimination (2022–2023) in Ferrara’s province: a real-world study |
| title_sort | italian screening protocol and genotypes characterization for hcv elimination 2022 2023 in ferrara s province a real world study |
| topic | Hepatitis C Population screening Viral genotypes Polymerase chain reaction Prevention Health system |
| url | https://doi.org/10.1038/s41598-025-92654-w |
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