Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, Brazil
Introduction: Human T-lymphotropic virus (HTLV) 1 and 2 infections can lead to neurological diseases, mainly in HIV/HTLV 1 coinfected. Furthermore, HTLV 1 infection in HIV/AIDS patients has also been associated with AIDS progression. Despite this, HTLV 1/2 infections are not of mandatory notificati...
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The Journal of Infection in Developing Countries
2021-10-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/14602 |
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| author | Marcela Santos de Souza Juliana Prado Gonçales Viviane Martha Santos deMorais José Valter Joaquim Silva Júnior Thaísa Regina Rocha Lopes Joanne Elizabeth Ferraz da Costa Maria Rosângela Cunha Duarte Côelho |
| author_facet | Marcela Santos de Souza Juliana Prado Gonçales Viviane Martha Santos deMorais José Valter Joaquim Silva Júnior Thaísa Regina Rocha Lopes Joanne Elizabeth Ferraz da Costa Maria Rosângela Cunha Duarte Côelho |
| author_sort | Marcela Santos de Souza |
| collection | DOAJ |
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Introduction: Human T-lymphotropic virus (HTLV) 1 and 2 infections can lead to neurological diseases, mainly in HIV/HTLV 1 coinfected. Furthermore, HTLV 1 infection in HIV/AIDS patients has also been associated with AIDS progression. Despite this, HTLV 1/2 infections are not of mandatory notification in Brazil. Here, we describe the prevalence of HTLV 1/2 in HIV/AIDS patients from Paraíba state, Brazil, as well as the sociodemographic characteristics of the coinfected individuals.
Methodology: Information about HIV viral load and TCD4 lymphocyte count were obtained from patients’ records. Data on the patients’ sociodemographic characteristics were obtained by interview conducted after signing the informed consent form. The serological diagnosis for HTLV 1/2 was performed by Enzyme-Linked Immunosorbent Assay (ELISA) and Western Blot (WB).
Results: A total of 401 HIV/AIDS patients participated in the study, of whom about 1.5% (6/401) were positive for antibodies against HTLV, specifically for HTLV 1, evaluated by both ELISA and WB. No risk factors were found associated with HIV/HTLV 1/2 coinfection.
Conclusions: We report a 1.5% prevalence of HTLV 1 infection in HIV/AIDS patients from Paraíba state. Although we have not identified risk factors associated with HTLV 1, we describe the most observed sociodemographic characteristics in HIV/HTLV 1 coinfection.
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| format | Article |
| id | doaj-art-0bb6b59f794d49639e7f563dfcf27a08 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-0bb6b59f794d49639e7f563dfcf27a082025-08-20T02:57:04ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802021-10-01151010.3855/jidc.14602Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, BrazilMarcela Santos de Souza0Juliana Prado Gonçales1Viviane Martha Santos deMorais2José Valter Joaquim Silva Júnior3Thaísa Regina Rocha Lopes4Joanne Elizabeth Ferraz da Costa5Maria Rosângela Cunha Duarte Côelho6Virology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, BrazilVirology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, BrazilVirology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, BrazilVirology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, BrazilVirology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, BrazilVirology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, BrazilVirology Sector, Keizo Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil Introduction: Human T-lymphotropic virus (HTLV) 1 and 2 infections can lead to neurological diseases, mainly in HIV/HTLV 1 coinfected. Furthermore, HTLV 1 infection in HIV/AIDS patients has also been associated with AIDS progression. Despite this, HTLV 1/2 infections are not of mandatory notification in Brazil. Here, we describe the prevalence of HTLV 1/2 in HIV/AIDS patients from Paraíba state, Brazil, as well as the sociodemographic characteristics of the coinfected individuals. Methodology: Information about HIV viral load and TCD4 lymphocyte count were obtained from patients’ records. Data on the patients’ sociodemographic characteristics were obtained by interview conducted after signing the informed consent form. The serological diagnosis for HTLV 1/2 was performed by Enzyme-Linked Immunosorbent Assay (ELISA) and Western Blot (WB). Results: A total of 401 HIV/AIDS patients participated in the study, of whom about 1.5% (6/401) were positive for antibodies against HTLV, specifically for HTLV 1, evaluated by both ELISA and WB. No risk factors were found associated with HIV/HTLV 1/2 coinfection. Conclusions: We report a 1.5% prevalence of HTLV 1 infection in HIV/AIDS patients from Paraíba state. Although we have not identified risk factors associated with HTLV 1, we describe the most observed sociodemographic characteristics in HIV/HTLV 1 coinfection. https://jidc.org/index.php/journal/article/view/14602HIV/AIDSHTLV 1/2EpidemiologyBrazil |
| spellingShingle | Marcela Santos de Souza Juliana Prado Gonçales Viviane Martha Santos deMorais José Valter Joaquim Silva Júnior Thaísa Regina Rocha Lopes Joanne Elizabeth Ferraz da Costa Maria Rosângela Cunha Duarte Côelho Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, Brazil Journal of Infection in Developing Countries HIV/AIDS HTLV 1/2 Epidemiology Brazil |
| title | Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, Brazil |
| title_full | Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, Brazil |
| title_fullStr | Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, Brazil |
| title_full_unstemmed | Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, Brazil |
| title_short | Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, Brazil |
| title_sort | prevalence and risk factor analysis for hiv htlv 1 2 coinfection in paraiba state brazil |
| topic | HIV/AIDS HTLV 1/2 Epidemiology Brazil |
| url | https://jidc.org/index.php/journal/article/view/14602 |
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