Evaluation of a national digital pre-implantation biopsy service for deceased-donor kidney transplantation in the UK (Pithia trial); a stepped-wedge cluster randomised registry trialResearch in context

Evaluation of a national digital pre-implantation biopsy service for deceased-donor kidney transplantation in the UK (Pithia trial); a stepped-wedge cluster randomised registry trialResearch in context

Summary: Background: Pre-implantation biopsy may help select kidneys retrieved from elderly deceased donors for transplantation, but concerns persist that it may cause unnecessary discard of kidneys that would have provided acceptable transplant function. The PITHIA trial tested the hypothesis that...

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Main Authors: Dominic M. Summers, John O.O. Ayorinde, Desley A. Neil, Karla Hemming, Laura Smith, Jennifer Mehew, Helen Thomas, Rosie Brown, Suzie Phillips, Emma Laing, Anna Sidders, Alison J. Deary, Rachel J. Johnson, Victoria Bardsley, Sathia Thiru, Meryl H. Griffiths, Ranmith Perera, Owen Cain, Candice Roufosse, Naomi Simmonds, Michael Sheaff, Natalie Brearley, Bindu Vydianath, Anna Paterson, Kishore Gopalakrishnan, Anastasios Chatzitolios, Chris J. Callaghan, Richard Jarvis, Frank J.M.F. Dor, Smarajit Dutta, Atul Bagul, Colin Wilson, Dan Ridgway, Adam Barlow, Richard Baker, Adnan Sharif, James McDaid, John Terrace, Lorna Marson, Debabrata Roy, James Hunter, Laszlo Szabo, Simon Knight, Karen Stevenson, Patrick Mark, Samuel Turner, Zia Moinuddin, Abbas Ghazanfar, Rajesh Sivaprakasam, Reza Motallebzadeh, Nicholas Torpey, Gareth Jones, Catherine Boffa, Paul Gibbs, Andrew Connor, Imran Saif, Badri Shrestha, Harry Hill, James Fotheringham, Gavin J. Pettigrew
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:The Lancet Regional Health. Europe
Subjects:
Pre-implantation biopsy analysis
Deceased donor kidney transplantation
Stepped wedge cluster randomised trial
National digital pathology service
Online Access:http://www.sciencedirect.com/science/article/pii/S2666776225001826
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