Effects of corticothalamic feedback depend on visual responsiveness and stimulus type
Summary: In the dorsolateral geniculate nucleus (dLGN) of the thalamus, stimulus-driven signals combine with modulatory inputs such as corticothalamic (CT) feedback and behavioral state, but their impact in shaping dLGN activity is debated. We recorded extracellular responses in the dLGN of mice vie...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225007424 |
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| author | Lisa Schmors Ann H. Kotkat Yannik Bauer Ziwei Huang Davide Crombie Lukas Sebastian Meyerolbersleben Sacha Sokoloski Philipp Berens Laura Busse |
| author_facet | Lisa Schmors Ann H. Kotkat Yannik Bauer Ziwei Huang Davide Crombie Lukas Sebastian Meyerolbersleben Sacha Sokoloski Philipp Berens Laura Busse |
| author_sort | Lisa Schmors |
| collection | DOAJ |
| description | Summary: In the dorsolateral geniculate nucleus (dLGN) of the thalamus, stimulus-driven signals combine with modulatory inputs such as corticothalamic (CT) feedback and behavioral state, but their impact in shaping dLGN activity is debated. We recorded extracellular responses in the dLGN of mice viewing a movie stimulus, while photosuppressing CT feedback and tracking locomotion and pupil size. Using generalized linear models fit to single neuron responses, we found that including CT feedback and behavioral state improved model predictions, especially for a subpopulation of neurons poorly responsive to the movie. Intriguingly, the impact of CT feedback was stronger without a patterned visual stimulus. Finally, for neurons sensitive to CT feedback, visual stimuli could be more easily discriminated when CT feedback was suppressed. Together, these results show that the effects of modulatory inputs in dLGN depend on visual responsiveness and stimulus type, with CT feedback affecting sensitivity and reliability, potentially to tune the thalamic relay. |
| format | Article |
| id | doaj-art-0baee586cd8e497395d9de4d33450b6f |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-0baee586cd8e497395d9de4d33450b6f2025-08-20T03:26:35ZengElsevieriScience2589-00422025-06-0128611248110.1016/j.isci.2025.112481Effects of corticothalamic feedback depend on visual responsiveness and stimulus typeLisa Schmors0Ann H. Kotkat1Yannik Bauer2Ziwei Huang3Davide Crombie4Lukas Sebastian Meyerolbersleben5Sacha Sokoloski6Philipp Berens7Laura Busse8Hertie Institute for AI in Brain Health, University of Tübingen, 72076 Tübingen, GermanyDivision of Neurobiology, Faculty of Biology, LMU Munich, 82152 Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg-Martinsried, GermanyDivision of Neurobiology, Faculty of Biology, LMU Munich, 82152 Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg-Martinsried, GermanyHertie Institute for AI in Brain Health, University of Tübingen, 72076 Tübingen, Germany; Tübingen AI Center, University of Tübingen, 72076 Tübingen, GermanyDivision of Neurobiology, Faculty of Biology, LMU Munich, 82152 Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg-Martinsried, GermanyDivision of Neurobiology, Faculty of Biology, LMU Munich, 82152 Planegg-Martinsried, Germany; Graduate School of Systemic Neurosciences (GSN), LMU Munich, 82152 Planegg-Martinsried, GermanyHertie Institute for AI in Brain Health, University of Tübingen, 72076 Tübingen, GermanyHertie Institute for AI in Brain Health, University of Tübingen, 72076 Tübingen, Germany; Tübingen AI Center, University of Tübingen, 72076 Tübingen, Germany; Corresponding authorDivision of Neurobiology, Faculty of Biology, LMU Munich, 82152 Planegg-Martinsried, Germany; Bernstein Center for Computational Neuroscience, 82152 Planegg-Martinsried, Germany; Corresponding authorSummary: In the dorsolateral geniculate nucleus (dLGN) of the thalamus, stimulus-driven signals combine with modulatory inputs such as corticothalamic (CT) feedback and behavioral state, but their impact in shaping dLGN activity is debated. We recorded extracellular responses in the dLGN of mice viewing a movie stimulus, while photosuppressing CT feedback and tracking locomotion and pupil size. Using generalized linear models fit to single neuron responses, we found that including CT feedback and behavioral state improved model predictions, especially for a subpopulation of neurons poorly responsive to the movie. Intriguingly, the impact of CT feedback was stronger without a patterned visual stimulus. Finally, for neurons sensitive to CT feedback, visual stimuli could be more easily discriminated when CT feedback was suppressed. Together, these results show that the effects of modulatory inputs in dLGN depend on visual responsiveness and stimulus type, with CT feedback affecting sensitivity and reliability, potentially to tune the thalamic relay.http://www.sciencedirect.com/science/article/pii/S2589004225007424NeuroscienceSensory neuroscience |
| spellingShingle | Lisa Schmors Ann H. Kotkat Yannik Bauer Ziwei Huang Davide Crombie Lukas Sebastian Meyerolbersleben Sacha Sokoloski Philipp Berens Laura Busse Effects of corticothalamic feedback depend on visual responsiveness and stimulus type iScience Neuroscience Sensory neuroscience |
| title | Effects of corticothalamic feedback depend on visual responsiveness and stimulus type |
| title_full | Effects of corticothalamic feedback depend on visual responsiveness and stimulus type |
| title_fullStr | Effects of corticothalamic feedback depend on visual responsiveness and stimulus type |
| title_full_unstemmed | Effects of corticothalamic feedback depend on visual responsiveness and stimulus type |
| title_short | Effects of corticothalamic feedback depend on visual responsiveness and stimulus type |
| title_sort | effects of corticothalamic feedback depend on visual responsiveness and stimulus type |
| topic | Neuroscience Sensory neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225007424 |
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