CXCR4+ mammary gland macrophageal niche promotes tumor initiating cell activity and immune suppression during tumorigenesis

CXCR4+ mammary gland macrophageal niche promotes tumor initiating cell activity and immune suppression during tumorigenesis

Abstract Tumor-initiating cells (TICs) share features and regulatory pathways with normal stem cells, yet how the stem cell niche contributes to tumorigenesis remains unclear. Here, we identify CXCR4+ macrophages as a niche population enriched in normal mammary ducts, where they promote the regenera...

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Main Authors: Eunmi Lee, Jason J. Hong, Gabriel Samcam Vargas, Natalie Sauerwald, Yong Wei, Xiang Hang, Chandra L. Theesfeld, Jean Arly A. Volmar, Jennifer M. Miller, Wei Wang, Sha Wang, Gary Laevsky, Christina J. DeCoste, Yibin Kang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59972-z
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https://doi.org/10.1038/s41467-025-59972-z

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