Effect of high, low, and asymmetric frequency subthalamic stimulation on speech and voice in Parkinson’s disease: a randomized trial

Abstract While bilateral high-frequency subthalamic nucleus stimulation (Bi-HFS) frequently worsens speech in Parkinson’s disease (PD), low-frequency stimulation (LFS) may alleviate gait deficits but lacks robust evidence for speech benefits. This randomized trial compared Bi-LFS (60 Hz) and Bi-HFS...

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Bibliographic Details
Main Authors: Zhitong Zeng, Mei Yang, Zhengyu Lin, Peng Huang, Yixin Pan, Chencheng Zhang, Bomin Sun, Dianyou Li
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01090-0
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