Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degeneration
Abstract Background To evaluate baseline optical coherence tomography (OCT) biomarkers in treatment-naïve patients with neovascular age-related macular degeneration (nAMD) and their correlation with visual acuity changes following intravitreal aflibercept injections. Methods A retrospective analysis...
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BMC
2025-02-01
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| Series: | International Journal of Retina and Vitreous |
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| Online Access: | https://doi.org/10.1186/s40942-025-00633-0 |
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| author | Hamid Riazi-Esfahani Hooshang Faghihi Fatemeh Bazvand Mohammadreza Mehrabi Bahar Hassan Khojasteh Ahmed Husein Ahmed Shahin Faghihi Ali Fakhraie Mohammad Hossein Zamani Samin Ghasemi Esmaeil Asadi Khameneh Elias Khalili Pour |
| author_facet | Hamid Riazi-Esfahani Hooshang Faghihi Fatemeh Bazvand Mohammadreza Mehrabi Bahar Hassan Khojasteh Ahmed Husein Ahmed Shahin Faghihi Ali Fakhraie Mohammad Hossein Zamani Samin Ghasemi Esmaeil Asadi Khameneh Elias Khalili Pour |
| author_sort | Hamid Riazi-Esfahani |
| collection | DOAJ |
| description | Abstract Background To evaluate baseline optical coherence tomography (OCT) biomarkers in treatment-naïve patients with neovascular age-related macular degeneration (nAMD) and their correlation with visual acuity changes following intravitreal aflibercept injections. Methods A retrospective analysis was conducted on treatment-naïve nAMD patients. Baseline OCT biomarkers, including shallow irregular pigment epithelial detachment (SIPED), subretinal hyperreflective material, subretinal fluid, intraretinal fluid (IRF), hyperreflective foci, and subretinal drusenoid deposits, were assessed. Patients received bimonthly aflibercept injections after three loading doses. Visual acuity changes were evaluated at 3 and 12 months. The maximum height and width of the largest pigment epithelial detachment (PED) were also measured. Results Among 89 eyes with nAMD, mean best-corrected visual acuity (BCVA) improved by 6 Early Treatment Diabetic Retinopathy Study (ETDRS) letters from baseline to month 3, with sustained improvement through month 12. Baseline IRF was associated with poorer visual acuity improvement at month 12, with patients showing a mean improvement of 1.6 ± 18.2 ETDRS letters versus 11.1 ± 10 ETDRS letters in those without IRF (P = 0.002). Multivariable analysis indicated SIPED was linked to lower visual gains at month 3 (P = 0.025). The largest PED width correlated significantly with lower BCVA gains at months 3 (P = 0.021) and 12 (P = 0.043), suggesting its potential as a prognostic factor. Conclusion Baseline OCT biomarkers, including SIPED, IRF, and PED width, may predict visual acuity changes in nAMD patients treated with aflibercept, highlighting the need for individualized monitoring. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-0ba4151231f04fe0b93347c35ca8316f |
| institution | Kabale University |
| issn | 2056-9920 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | International Journal of Retina and Vitreous |
| spelling | doaj-art-0ba4151231f04fe0b93347c35ca8316f2025-02-09T12:49:11ZengBMCInternational Journal of Retina and Vitreous2056-99202025-02-0111111310.1186/s40942-025-00633-0Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degenerationHamid Riazi-Esfahani0Hooshang Faghihi1Fatemeh Bazvand2Mohammadreza Mehrabi Bahar3Hassan Khojasteh4Ahmed Husein Ahmed5Shahin Faghihi6Ali Fakhraie7Mohammad Hossein Zamani8Samin Ghasemi9Esmaeil Asadi Khameneh10Elias Khalili Pour11Farabi Eye Hospital, Tehran University of Medical SciencesFarabi Eye Hospital, Tehran University of Medical SciencesFarabi Eye Hospital, Tehran University of Medical SciencesFarabi Eye Hospital, Tehran University of Medical SciencesBascom Palmer Eye Institute, University of MiamiFarabi Eye Hospital, Tehran University of Medical SciencesRetinal Disorders and Ophthalmic Genetics Division, Stein Eye Institute, University of California of Los Angeles, David Geffen School of Medicine at UCLAFarabi Eye Hospital, Tehran University of Medical SciencesFarabi Eye Hospital, Tehran University of Medical SciencesFarabi Eye Hospital, Tehran University of Medical SciencesFarabi Eye Hospital, Tehran University of Medical SciencesFarabi Eye Hospital, Tehran University of Medical SciencesAbstract Background To evaluate baseline optical coherence tomography (OCT) biomarkers in treatment-naïve patients with neovascular age-related macular degeneration (nAMD) and their correlation with visual acuity changes following intravitreal aflibercept injections. Methods A retrospective analysis was conducted on treatment-naïve nAMD patients. Baseline OCT biomarkers, including shallow irregular pigment epithelial detachment (SIPED), subretinal hyperreflective material, subretinal fluid, intraretinal fluid (IRF), hyperreflective foci, and subretinal drusenoid deposits, were assessed. Patients received bimonthly aflibercept injections after three loading doses. Visual acuity changes were evaluated at 3 and 12 months. The maximum height and width of the largest pigment epithelial detachment (PED) were also measured. Results Among 89 eyes with nAMD, mean best-corrected visual acuity (BCVA) improved by 6 Early Treatment Diabetic Retinopathy Study (ETDRS) letters from baseline to month 3, with sustained improvement through month 12. Baseline IRF was associated with poorer visual acuity improvement at month 12, with patients showing a mean improvement of 1.6 ± 18.2 ETDRS letters versus 11.1 ± 10 ETDRS letters in those without IRF (P = 0.002). Multivariable analysis indicated SIPED was linked to lower visual gains at month 3 (P = 0.025). The largest PED width correlated significantly with lower BCVA gains at months 3 (P = 0.021) and 12 (P = 0.043), suggesting its potential as a prognostic factor. Conclusion Baseline OCT biomarkers, including SIPED, IRF, and PED width, may predict visual acuity changes in nAMD patients treated with aflibercept, highlighting the need for individualized monitoring. Clinical trial number Not applicable.https://doi.org/10.1186/s40942-025-00633-0Age-related macular degenerationChoroidal neovascularizationAnti-vascular endothelial growth factorOptical coherence tomography |
| spellingShingle | Hamid Riazi-Esfahani Hooshang Faghihi Fatemeh Bazvand Mohammadreza Mehrabi Bahar Hassan Khojasteh Ahmed Husein Ahmed Shahin Faghihi Ali Fakhraie Mohammad Hossein Zamani Samin Ghasemi Esmaeil Asadi Khameneh Elias Khalili Pour Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degeneration International Journal of Retina and Vitreous Age-related macular degeneration Choroidal neovascularization Anti-vascular endothelial growth factor Optical coherence tomography |
| title | Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degeneration |
| title_full | Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degeneration |
| title_fullStr | Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degeneration |
| title_full_unstemmed | Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degeneration |
| title_short | Predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age-related macular degeneration |
| title_sort | predictive value of different baseline optical coherence tomography biomarkers for visual acuity changes in neovascular age related macular degeneration |
| topic | Age-related macular degeneration Choroidal neovascularization Anti-vascular endothelial growth factor Optical coherence tomography |
| url | https://doi.org/10.1186/s40942-025-00633-0 |
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