Exploring the impacts of senescence on implantation and early embryonic development using totipotent cell-derived blastoids

Exploring the impacts of senescence on implantation and early embryonic development using totipotent cell-derived blastoids

Introduction: Advanced maternal age is associated with reduced implantation and pregnancy rates, yet the underlying mechanisms remain poorly understood, and research models are limited. Objectives: Here, we aim to elucidate the impacts of senescence on implantation ability by employing blastoids to...

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Bibliographic Details
Main Authors: Yuxin Luo, Chenrui An, Ke Zhong, Ping Zhou, Dan Li, Hui Liu, Qing Guo, Wei Wei, Hen Pan, Zheying Min, Rong Li, Yang Yu, Yong Fan
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Journal of Advanced Research
Subjects:
Blastocysts
Blastoids
Totipotent
Implantation
Senescence
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224000730
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