Estimation of Lamotrigine by RP-HPLC Method
A rapid and reproducible reverse phase high performance liquid chromatographic method has been developed for the estimation of lamotrigine in its pure form as well as in pharmaceutical dosage forms. Chromatography was carried out on a Luna C18 column using a mixture of potassium dihydrogen phosphate...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/754745 |
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| author | D. Anantha Kumar CH. Venkata Kumar P. Seetharamaiah J. V. L. N. Seshagiri Rao |
| author_facet | D. Anantha Kumar CH. Venkata Kumar P. Seetharamaiah J. V. L. N. Seshagiri Rao |
| author_sort | D. Anantha Kumar |
| collection | DOAJ |
| description | A rapid and reproducible reverse phase high performance liquid chromatographic method has been developed for the estimation of lamotrigine in its pure form as well as in pharmaceutical dosage forms. Chromatography was carried out on a Luna C18 column using a mixture of potassium dihydrogen phosphate buffer (pH 7.3) and methanol in a ratio of 60:40 v/v as the mobile phase at a flow rate of 1.0 mL/min. The detection was done at 305 nm. The retention time of the drug was 6.1 min. The method produced linear responses in the concentration range of 10 to 70 μg/mL of lamotrigine. The method was found to be reproducible for analysis of the drug in tablet dosage forms. |
| format | Article |
| id | doaj-art-0b98016ca6514e22a4090b2972bf0873 |
| institution | OA Journals |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-0b98016ca6514e22a4090b2972bf08732025-08-20T02:03:28ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-017S1S203S20810.1155/2010/754745Estimation of Lamotrigine by RP-HPLC MethodD. Anantha Kumar0CH. Venkata Kumar1P. Seetharamaiah2J. V. L. N. Seshagiri Rao3Pharmaceutical Analysis and Quality Assurance Division, College of Pharmaceutical Sciences Andhra University, Visakhapatnam-530 003, IndiaPharmaceutical Analysis and Quality Assurance Division, College of Pharmaceutical Sciences Andhra University, Visakhapatnam-530 003, IndiaPharmaceutical Analysis and Quality Assurance Division, College of Pharmaceutical Sciences Andhra University, Visakhapatnam-530 003, IndiaPharmaceutical Analysis and Quality Assurance Division, College of Pharmaceutical Sciences Andhra University, Visakhapatnam-530 003, IndiaA rapid and reproducible reverse phase high performance liquid chromatographic method has been developed for the estimation of lamotrigine in its pure form as well as in pharmaceutical dosage forms. Chromatography was carried out on a Luna C18 column using a mixture of potassium dihydrogen phosphate buffer (pH 7.3) and methanol in a ratio of 60:40 v/v as the mobile phase at a flow rate of 1.0 mL/min. The detection was done at 305 nm. The retention time of the drug was 6.1 min. The method produced linear responses in the concentration range of 10 to 70 μg/mL of lamotrigine. The method was found to be reproducible for analysis of the drug in tablet dosage forms.http://dx.doi.org/10.1155/2010/754745 |
| spellingShingle | D. Anantha Kumar CH. Venkata Kumar P. Seetharamaiah J. V. L. N. Seshagiri Rao Estimation of Lamotrigine by RP-HPLC Method E-Journal of Chemistry |
| title | Estimation of Lamotrigine by RP-HPLC Method |
| title_full | Estimation of Lamotrigine by RP-HPLC Method |
| title_fullStr | Estimation of Lamotrigine by RP-HPLC Method |
| title_full_unstemmed | Estimation of Lamotrigine by RP-HPLC Method |
| title_short | Estimation of Lamotrigine by RP-HPLC Method |
| title_sort | estimation of lamotrigine by rp hplc method |
| url | http://dx.doi.org/10.1155/2010/754745 |
| work_keys_str_mv | AT dananthakumar estimationoflamotriginebyrphplcmethod AT chvenkatakumar estimationoflamotriginebyrphplcmethod AT pseetharamaiah estimationoflamotriginebyrphplcmethod AT jvlnseshagirirao estimationoflamotriginebyrphplcmethod |