β-Cell Generation: Can Rodent Studies Be Translated to Humans?
β-cell replacement by allogeneic islet transplantation is a promising approach for patients with type 1 diabetes, but the shortage of organ donors requires new sources of β cells. Islet regeneration in vivo and generation of β-cells ex vivo followed by transplantation represent attractive therapeuti...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2011/892453 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850231590518521856 |
|---|---|
| author | Françoise Carlotti Arnaud Zaldumbide Johanne H. Ellenbroek H. Siebe Spijker Rob C. Hoeben Eelco J. de Koning |
| author_facet | Françoise Carlotti Arnaud Zaldumbide Johanne H. Ellenbroek H. Siebe Spijker Rob C. Hoeben Eelco J. de Koning |
| author_sort | Françoise Carlotti |
| collection | DOAJ |
| description | β-cell replacement by allogeneic islet transplantation is a promising approach for patients with type 1 diabetes, but the shortage of organ donors requires new sources of β cells. Islet regeneration in vivo and generation of β-cells ex vivo followed by transplantation represent attractive therapeutic alternatives to restore the β-cell mass. In this paper, we discuss different postnatal cell types that have been envisaged as potential sources for future β-cell replacement therapy. The ultimate goal being translation to the clinic, a particular attention is given to the discrepancies between findings from studies performed in rodents (both ex vivo on primary cells and in vivo on animal models), when compared with clinical data and studies performed on human cells. |
| format | Article |
| id | doaj-art-0b9592a33d9f44faa71802ec857ceddb |
| institution | OA Journals |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-0b9592a33d9f44faa71802ec857ceddb2025-08-20T02:03:28ZengWileyJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/892453892453β-Cell Generation: Can Rodent Studies Be Translated to Humans?Françoise Carlotti0Arnaud Zaldumbide1Johanne H. Ellenbroek2H. Siebe Spijker3Rob C. Hoeben4Eelco J. de Koning5Department of Nephrology, Leiden University Medical Center, Postal Zone C3-P, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Molecular Cell Biology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Nephrology, Leiden University Medical Center, Postal Zone C3-P, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Nephrology, Leiden University Medical Center, Postal Zone C3-P, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Molecular Cell Biology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Nephrology, Leiden University Medical Center, Postal Zone C3-P, P.O. Box 9600, 2300 RC Leiden, The Netherlandsβ-cell replacement by allogeneic islet transplantation is a promising approach for patients with type 1 diabetes, but the shortage of organ donors requires new sources of β cells. Islet regeneration in vivo and generation of β-cells ex vivo followed by transplantation represent attractive therapeutic alternatives to restore the β-cell mass. In this paper, we discuss different postnatal cell types that have been envisaged as potential sources for future β-cell replacement therapy. The ultimate goal being translation to the clinic, a particular attention is given to the discrepancies between findings from studies performed in rodents (both ex vivo on primary cells and in vivo on animal models), when compared with clinical data and studies performed on human cells.http://dx.doi.org/10.1155/2011/892453 |
| spellingShingle | Françoise Carlotti Arnaud Zaldumbide Johanne H. Ellenbroek H. Siebe Spijker Rob C. Hoeben Eelco J. de Koning β-Cell Generation: Can Rodent Studies Be Translated to Humans? Journal of Transplantation |
| title | β-Cell Generation: Can Rodent Studies Be Translated to Humans? |
| title_full | β-Cell Generation: Can Rodent Studies Be Translated to Humans? |
| title_fullStr | β-Cell Generation: Can Rodent Studies Be Translated to Humans? |
| title_full_unstemmed | β-Cell Generation: Can Rodent Studies Be Translated to Humans? |
| title_short | β-Cell Generation: Can Rodent Studies Be Translated to Humans? |
| title_sort | β cell generation can rodent studies be translated to humans |
| url | http://dx.doi.org/10.1155/2011/892453 |
| work_keys_str_mv | AT francoisecarlotti bcellgenerationcanrodentstudiesbetranslatedtohumans AT arnaudzaldumbide bcellgenerationcanrodentstudiesbetranslatedtohumans AT johannehellenbroek bcellgenerationcanrodentstudiesbetranslatedtohumans AT hsiebespijker bcellgenerationcanrodentstudiesbetranslatedtohumans AT robchoeben bcellgenerationcanrodentstudiesbetranslatedtohumans AT eelcojdekoning bcellgenerationcanrodentstudiesbetranslatedtohumans |