Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study
Background There are limited data describing the long-term outcomes of severe COVID-19. We aimed to evaluate the long-term psychosocial and physical consequences of severe COVID-19 for patients.Methods We conducted a multicentre observational cohort study; between 3 and 7 months posthospital dischar...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2021-01-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/8/1/e001080.full |
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| author | Kevin G Blyth Stefan Siebert Iain McInnes Malcolm Sim Martin Shaw Tara Quasim Lisa Gemmell Pamela MacTavish Helen Devine Joanne McPeake Mark Henderson Varun Sharma Kathryn Puxty Gillian Fleming Justine Griffin Pauline Grose Philip Henderson Lucy Hogg Kirstin King Peter O'Brien Callum Rainey Laura Strachan |
| author_facet | Kevin G Blyth Stefan Siebert Iain McInnes Malcolm Sim Martin Shaw Tara Quasim Lisa Gemmell Pamela MacTavish Helen Devine Joanne McPeake Mark Henderson Varun Sharma Kathryn Puxty Gillian Fleming Justine Griffin Pauline Grose Philip Henderson Lucy Hogg Kirstin King Peter O'Brien Callum Rainey Laura Strachan |
| author_sort | Kevin G Blyth |
| collection | DOAJ |
| description | Background There are limited data describing the long-term outcomes of severe COVID-19. We aimed to evaluate the long-term psychosocial and physical consequences of severe COVID-19 for patients.Methods We conducted a multicentre observational cohort study; between 3 and 7 months posthospital discharge, patients who had been admitted to critical care due to severe COVID-19 were invited to an established recovery service. Standardised questionnaires concerning emotional, physical and social recovery, including information on employment, were completed by patients. Using propensity score matching, we explored outcomes between patients admitted to critical care with and without COVID-19, using data from the same recovery programme.Results Between July 2020 and December 2020, 93 patients who had been admitted to critical with COVID-19 participated. Emotional dysfunction was common: 46.2% of patients had symptoms of anxiety and 34.4% symptoms of depression. At follow-up 53.7% of previously employed patients had returned to employment; there was a significant difference in return to employment across the socio-economic gradient, with lower numbers of patients from the most deprived areas returning to employment (p=0.03). 91 (97.8%) COVID-19 patients were matched with 91 non-COVID-19 patients. There were no significant differences in any measured outcomes between the two cohorts.Interpretation Emotional and social problems are common in survivors of severe COVID-19 infection. Coordinated rehabilitation is required to ensure patients make an optimal recovery. |
| format | Article |
| id | doaj-art-0b8ffbf1e45e4db996e5efc45c8b6945 |
| institution | Kabale University |
| issn | 2052-4439 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Respiratory Research |
| spelling | doaj-art-0b8ffbf1e45e4db996e5efc45c8b69452024-11-24T17:00:09ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392021-01-018110.1136/bmjresp-2021-001080Long-term outcomes following severe COVID-19 infection: a propensity matched cohort studyKevin G Blyth0Stefan Siebert1Iain McInnes2Malcolm Sim3Martin Shaw4Tara Quasim5Lisa Gemmell6Pamela MacTavish7Helen Devine8Joanne McPeake9Mark Henderson10Varun Sharma11Kathryn Puxty12Gillian Fleming13Justine Griffin14Pauline Grose15Philip Henderson16Lucy Hogg17Kirstin King18Peter O'Brien19Callum Rainey20Laura Strachan21Glasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, UKInstitute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom5 University of Glasgow, College of Medical, Veterinary and Life Science, Glasgow, UKAcademic Unit of Anaesthesia, Peri-operative Medicine and Critical Care, University of Glasgow School of Medicine Dentistry and Nursing, Glasgow, UKprincipal clinical physicistAcademic Unit of Anaesthesia, Peri-operative Medicine and Critical Care, University of Glasgow School of Medicine Dentistry and Nursing, Glasgow, UK1Freeman Hospital, Newcastle upon Tyne, UKGlasgow Royal Infirmary, NHS Greater Glasgow and Clyde, Glasgow, UKMitochondria Research Group, Newcastle University, Newcastle upon Tyne, UKUniversity of Cambridge School of Clinical Medicine, Cambridge, UKscience editor1 NHS Greater Glasgow and Clyde, Glasgow, UK1 NHS Greater Glasgow and Clyde, Glasgow, UK4 NHS Fife, Kirkcaldy, UK1 NHS Greater Glasgow and Clyde, Glasgow, UKGeneral Medicine, Glasgow Royal Infirmary, Glasgow, UKRoyal Alexandra Hospital, NHS Greater Glasgow and Clyde, Glasgow, UKIntensive Care Unit, Victoria Hospital, NHS Fife, Kirkcaldy, UK1 NHS Greater Glasgow and Clyde, Glasgow, UKIntensive Care Unit, University Hospital Crosshouse, NHS Ayrshire and Arran, Kilmarnock, UK6 NHS Ayrshire and Arran, Ayr, UKIntensive Care Unit, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, Glasgow, UKBackground There are limited data describing the long-term outcomes of severe COVID-19. We aimed to evaluate the long-term psychosocial and physical consequences of severe COVID-19 for patients.Methods We conducted a multicentre observational cohort study; between 3 and 7 months posthospital discharge, patients who had been admitted to critical care due to severe COVID-19 were invited to an established recovery service. Standardised questionnaires concerning emotional, physical and social recovery, including information on employment, were completed by patients. Using propensity score matching, we explored outcomes between patients admitted to critical care with and without COVID-19, using data from the same recovery programme.Results Between July 2020 and December 2020, 93 patients who had been admitted to critical with COVID-19 participated. Emotional dysfunction was common: 46.2% of patients had symptoms of anxiety and 34.4% symptoms of depression. At follow-up 53.7% of previously employed patients had returned to employment; there was a significant difference in return to employment across the socio-economic gradient, with lower numbers of patients from the most deprived areas returning to employment (p=0.03). 91 (97.8%) COVID-19 patients were matched with 91 non-COVID-19 patients. There were no significant differences in any measured outcomes between the two cohorts.Interpretation Emotional and social problems are common in survivors of severe COVID-19 infection. Coordinated rehabilitation is required to ensure patients make an optimal recovery.https://bmjopenrespres.bmj.com/content/8/1/e001080.full |
| spellingShingle | Kevin G Blyth Stefan Siebert Iain McInnes Malcolm Sim Martin Shaw Tara Quasim Lisa Gemmell Pamela MacTavish Helen Devine Joanne McPeake Mark Henderson Varun Sharma Kathryn Puxty Gillian Fleming Justine Griffin Pauline Grose Philip Henderson Lucy Hogg Kirstin King Peter O'Brien Callum Rainey Laura Strachan Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study BMJ Open Respiratory Research |
| title | Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study |
| title_full | Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study |
| title_fullStr | Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study |
| title_full_unstemmed | Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study |
| title_short | Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study |
| title_sort | long term outcomes following severe covid 19 infection a propensity matched cohort study |
| url | https://bmjopenrespres.bmj.com/content/8/1/e001080.full |
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