Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis
Silicosis is a devastating disease caused by inhalation of silica dust that leads to inflammatory cascade and then scarring of the lung tissue. Increasing evidences indicate that soluble receptor for advanced glycation end products (sRAGE) is involved in inflammatory diseases. However, no data on th...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/2683753 |
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| author | Heliang Liu Jingjing Ma Tian Jiang Enhong Li Xiaokun Zhao Ying Wang Jie Cui Xiaohui Hao Lingli Guo |
| author_facet | Heliang Liu Jingjing Ma Tian Jiang Enhong Li Xiaokun Zhao Ying Wang Jie Cui Xiaohui Hao Lingli Guo |
| author_sort | Heliang Liu |
| collection | DOAJ |
| description | Silicosis is a devastating disease caused by inhalation of silica dust that leads to inflammatory cascade and then scarring of the lung tissue. Increasing evidences indicate that soluble receptor for advanced glycation end products (sRAGE) is involved in inflammatory diseases. However, no data on the possible relationship between sRAGE and inflammation of silicosis are available. In this study, serum from subjects with silicosis (n=59) or from healthy controls (HC, n=14) was analyzed for the secretion of sRAGE, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), transforming growth factor-β1 (TGF-β1), and oxidized low-density lipoprotein (ox-LDL). The associations between sRAGE and cytokines and ox-LDL and lung function were assessed by Pearson’s correlation analyses. Mean levels of serum sRAGE were lower in silicosis than those in controls (p<0.05). The subjects who had a longer term of occupational exposure had higher levels of sRAGE (p<0.05). The secretion of TNF-α, IL-1β, IL-6, TGF-β1, and ox-LDL was significantly higher in the silicosis group than that in the HC group (p<0.05). Furthermore, the levels of sRAGE were negatively correlated with TNF-α, IL-6, IL-1β, and ox-LDL. There is no correlation between sRAGE and TGF-β1 and lung function. The optimal point of sRAGE for differentiating silicosis from healthy controls was 14250.02 pg/ml by ROC curve analysis. A decrease in serum sRAGE and its association with inflammatory response might suggest a role for sRAGE in the pathogenesis of silicosis. |
| format | Article |
| id | doaj-art-0b8bf4e2d25e45ba8275d150b64fa79e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0b8bf4e2d25e45ba8275d150b64fa79e2025-02-03T05:44:13ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/26837532683753Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in SilicosisHeliang Liu0Jingjing Ma1Tian Jiang2Enhong Li3Xiaokun Zhao4Ying Wang5Jie Cui6Xiaohui Hao7Lingli Guo8Hebei Key Laboratory of Organ Fibrosis, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, ChinaHebei Key Laboratory of Organ Fibrosis, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, ChinaHebei Key Laboratory of Organ Fibrosis, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, ChinaHebei Key Laboratory of Organ Fibrosis, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, ChinaHebei Key Laboratory of Organ Fibrosis, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, ChinaHebei Key Laboratory of Organ Fibrosis, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, ChinaHebei Key Laboratory of Organ Fibrosis, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, ChinaHebei Key Laboratory of Organ Fibrosis, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, ChinaHebei Key Laboratory of Organ Fibrosis, School of Public Health, North China University of Science and Technology, Tangshan, Hebei 063210, ChinaSilicosis is a devastating disease caused by inhalation of silica dust that leads to inflammatory cascade and then scarring of the lung tissue. Increasing evidences indicate that soluble receptor for advanced glycation end products (sRAGE) is involved in inflammatory diseases. However, no data on the possible relationship between sRAGE and inflammation of silicosis are available. In this study, serum from subjects with silicosis (n=59) or from healthy controls (HC, n=14) was analyzed for the secretion of sRAGE, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), transforming growth factor-β1 (TGF-β1), and oxidized low-density lipoprotein (ox-LDL). The associations between sRAGE and cytokines and ox-LDL and lung function were assessed by Pearson’s correlation analyses. Mean levels of serum sRAGE were lower in silicosis than those in controls (p<0.05). The subjects who had a longer term of occupational exposure had higher levels of sRAGE (p<0.05). The secretion of TNF-α, IL-1β, IL-6, TGF-β1, and ox-LDL was significantly higher in the silicosis group than that in the HC group (p<0.05). Furthermore, the levels of sRAGE were negatively correlated with TNF-α, IL-6, IL-1β, and ox-LDL. There is no correlation between sRAGE and TGF-β1 and lung function. The optimal point of sRAGE for differentiating silicosis from healthy controls was 14250.02 pg/ml by ROC curve analysis. A decrease in serum sRAGE and its association with inflammatory response might suggest a role for sRAGE in the pathogenesis of silicosis.http://dx.doi.org/10.1155/2020/2683753 |
| spellingShingle | Heliang Liu Jingjing Ma Tian Jiang Enhong Li Xiaokun Zhao Ying Wang Jie Cui Xiaohui Hao Lingli Guo Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis Mediators of Inflammation |
| title | Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis |
| title_full | Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis |
| title_fullStr | Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis |
| title_full_unstemmed | Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis |
| title_short | Decreased Soluble Receptor of Advanced Glycation End Product Levels Correlated with Inflammation in Silicosis |
| title_sort | decreased soluble receptor of advanced glycation end product levels correlated with inflammation in silicosis |
| url | http://dx.doi.org/10.1155/2020/2683753 |
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