p97/VCP is required for piecemeal autophagy of aggresomes

p97/VCP is required for piecemeal autophagy of aggresomes

Abstract Metazoan cells adapt to the exhaustion of protein quality control (PQC) systems by sequestering aggregation-prone proteins in large, pericentriolar structures termed aggresomes. Defects in both aggresome formation and clearance affect proteostasis and have been linked to neurodegenerative d...

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Bibliographic Details
Main Authors: Maria Körner, Paul Müller, Hirak Das, Felix Kraus, Timo Pfeuffer, Sven Spielhaupter, Silke Oeljeklaus, Christina Schülein-Völk, J. Wade Harper, Bettina Warscheid, Alexander Buchberger
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59556-x
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