Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes
Purpose. To identify and correlate age-related changes in outer retinal layers’ thickness and choroidal thickness (CT) in the normal eyes using spectral-domain optical coherence tomography (SD-OCT) and to investigate factors affecting these changes. Study Design. Observational cross-sectional study....
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/1698967 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563613596909568 |
|---|---|
| author | Mona Kamal Abdellatif Yasser Abdelmaguid Mohamed Elzankalony Ahmed Abdelmonsef Abdelhamid Ebeid Weam Mohamed Ebeid |
| author_facet | Mona Kamal Abdellatif Yasser Abdelmaguid Mohamed Elzankalony Ahmed Abdelmonsef Abdelhamid Ebeid Weam Mohamed Ebeid |
| author_sort | Mona Kamal Abdellatif |
| collection | DOAJ |
| description | Purpose. To identify and correlate age-related changes in outer retinal layers’ thickness and choroidal thickness (CT) in the normal eyes using spectral-domain optical coherence tomography (SD-OCT) and to investigate factors affecting these changes. Study Design. Observational cross-sectional study. Subjects and Methods. We studied 125 healthy Egyptians between 20 and 79 years old. Patients were divided into 3 groups: group 1 (20–40 years), group 2 (40–60 years), and group 3 (>60 years). All patients had full ophthalmic examination. SD-OCT was done to measure the 9 ETDRS macular grid sectors of retinal pigment epithelium and photoreceptor outer segment (RPE-OS), outer nuclear layer and photoreceptor inner segment (ONL-IS), and choroidal thickness (CT) (by enhanced depth imaging). Results. RPE-OS was significantly thinner in group 3 than in the other 2 groups (central: P<0.001). Moreover, the 3 groups were significantly different from each other regarding the CT (central: P<0.001); significant thinning was noticed in the choroid with age. The 3 groups did not show significant difference concerning the ONL-IS thickness. RPE-OS and CT showed statistically significant negative correlation with age (central RPE-OS: r = −0 C.345, P<0.001, and central CT: r = −0.725, P<0.001) while ONL-IS showed statistically nonsignificant correlation with age (central ONL-IS: r = −0.08, P=0.376). Multiple regression analysis revealed that the most important determinant of central 1 mm RPE-OS thickness in this study was age (β = −0.087, P=0.010) rather than choroidal thinning (β = 0.001, P=0.879). Conclusion. RPE-OS layer thickness shows significant thinning with increasing age, and with decrease in CT, however, age is the most determinant factor of this thinning. |
| format | Article |
| id | doaj-art-0b85dd2632a04c008c1339585636137e |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-0b85dd2632a04c008c1339585636137e2025-02-03T01:12:57ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/16989671698967Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal EyesMona Kamal Abdellatif0Yasser Abdelmaguid Mohamed Elzankalony1Ahmed Abdelmonsef Abdelhamid Ebeid2Weam Mohamed Ebeid3Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartment of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartment of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, EgyptDepartment of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, EgyptPurpose. To identify and correlate age-related changes in outer retinal layers’ thickness and choroidal thickness (CT) in the normal eyes using spectral-domain optical coherence tomography (SD-OCT) and to investigate factors affecting these changes. Study Design. Observational cross-sectional study. Subjects and Methods. We studied 125 healthy Egyptians between 20 and 79 years old. Patients were divided into 3 groups: group 1 (20–40 years), group 2 (40–60 years), and group 3 (>60 years). All patients had full ophthalmic examination. SD-OCT was done to measure the 9 ETDRS macular grid sectors of retinal pigment epithelium and photoreceptor outer segment (RPE-OS), outer nuclear layer and photoreceptor inner segment (ONL-IS), and choroidal thickness (CT) (by enhanced depth imaging). Results. RPE-OS was significantly thinner in group 3 than in the other 2 groups (central: P<0.001). Moreover, the 3 groups were significantly different from each other regarding the CT (central: P<0.001); significant thinning was noticed in the choroid with age. The 3 groups did not show significant difference concerning the ONL-IS thickness. RPE-OS and CT showed statistically significant negative correlation with age (central RPE-OS: r = −0 C.345, P<0.001, and central CT: r = −0.725, P<0.001) while ONL-IS showed statistically nonsignificant correlation with age (central ONL-IS: r = −0.08, P=0.376). Multiple regression analysis revealed that the most important determinant of central 1 mm RPE-OS thickness in this study was age (β = −0.087, P=0.010) rather than choroidal thinning (β = 0.001, P=0.879). Conclusion. RPE-OS layer thickness shows significant thinning with increasing age, and with decrease in CT, however, age is the most determinant factor of this thinning.http://dx.doi.org/10.1155/2019/1698967 |
| spellingShingle | Mona Kamal Abdellatif Yasser Abdelmaguid Mohamed Elzankalony Ahmed Abdelmonsef Abdelhamid Ebeid Weam Mohamed Ebeid Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes Journal of Ophthalmology |
| title | Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes |
| title_full | Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes |
| title_fullStr | Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes |
| title_full_unstemmed | Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes |
| title_short | Outer Retinal Layers’ Thickness Changes in relation to Age and Choroidal Thickness in Normal Eyes |
| title_sort | outer retinal layers thickness changes in relation to age and choroidal thickness in normal eyes |
| url | http://dx.doi.org/10.1155/2019/1698967 |
| work_keys_str_mv | AT monakamalabdellatif outerretinallayersthicknesschangesinrelationtoageandchoroidalthicknessinnormaleyes AT yasserabdelmaguidmohamedelzankalony outerretinallayersthicknesschangesinrelationtoageandchoroidalthicknessinnormaleyes AT ahmedabdelmonsefabdelhamidebeid outerretinallayersthicknesschangesinrelationtoageandchoroidalthicknessinnormaleyes AT weammohamedebeid outerretinallayersthicknesschangesinrelationtoageandchoroidalthicknessinnormaleyes |