Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery
Background. Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction. The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB. Methods. Thirty patients undergoi...
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| Format: | Article |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/341740 |
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| author | Tso-Chou Lin Feng-Yen Lin Yi-Wen Lin Che-Hao Hsu Go-Shine Huang Zhi-Fu Wu Yi-Ting Tsai Chih-Yuan Lin Chi-Yuan Li Chien-Sung Tsai |
| author_facet | Tso-Chou Lin Feng-Yen Lin Yi-Wen Lin Che-Hao Hsu Go-Shine Huang Zhi-Fu Wu Yi-Ting Tsai Chih-Yuan Lin Chi-Yuan Li Chien-Sung Tsai |
| author_sort | Tso-Chou Lin |
| collection | DOAJ |
| description | Background. Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction. The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB. Methods. Thirty patients undergoing elective cardiac surgery were included. Arterial blood was sampled at 6 sequential points (before anesthesia induction, before CPB and at 2, 4, 6, and 24 h after beginning CPB) for plasma MMP-9 concentrations by ELISA. The perioperative laboratory data and variables, including bypass time, PaO2/FiO2, and extubation time, were also recorded. Results. The plasma MMP-9 concentrations significantly elevated at 2–6 h after beginning CPB (P<0.001) and returned to the preanesthesia level at 24 h (P=0.23), with predominant neutrophil counts after surgery (P<0.001). The plasma MMP-9 levels at 4 and 6 h were not correlated with prolonged CPB time and displayed no association with postoperative PaO2/FiO2, regardless of reduced ratio from preoperative 342.9±81.2 to postoperative 207.3±121.3 mmHg (P<0.001). Conclusion. Elective cardiac surgery with CPB induced short-term elevation of plasma MMP-9 concentrations within 24 hours, however, without significant correlation with CPB time and postoperative pulmonary dysfunction, despite predominantly increased neutrophils and reduced oxygenation. |
| format | Article |
| id | doaj-art-0b7f76af7412424eb7aeb3a0926b9f7f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0b7f76af7412424eb7aeb3a0926b9f7f2025-02-03T07:24:32ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/341740341740Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac SurgeryTso-Chou Lin0Feng-Yen Lin1Yi-Wen Lin2Che-Hao Hsu3Go-Shine Huang4Zhi-Fu Wu5Yi-Ting Tsai6Chih-Yuan Lin7Chi-Yuan Li8Chien-Sung Tsai9Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, TaiwanDivision of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDepartment of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDivision of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanDivision of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanGraduate Institute of Clinical Medical Sciences, China Medical University, Taichung, TaiwanDivision of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, TaiwanBackground. Cardiopulmonary bypass (CPB) causes release of matrix metalloproteinase- (MMP-) 9, contributing to pulmonary infiltration and dysfunction. The aims were to investigate MMP-9 production and associated perioperative variables and oxygenation following CPB. Methods. Thirty patients undergoing elective cardiac surgery were included. Arterial blood was sampled at 6 sequential points (before anesthesia induction, before CPB and at 2, 4, 6, and 24 h after beginning CPB) for plasma MMP-9 concentrations by ELISA. The perioperative laboratory data and variables, including bypass time, PaO2/FiO2, and extubation time, were also recorded. Results. The plasma MMP-9 concentrations significantly elevated at 2–6 h after beginning CPB (P<0.001) and returned to the preanesthesia level at 24 h (P=0.23), with predominant neutrophil counts after surgery (P<0.001). The plasma MMP-9 levels at 4 and 6 h were not correlated with prolonged CPB time and displayed no association with postoperative PaO2/FiO2, regardless of reduced ratio from preoperative 342.9±81.2 to postoperative 207.3±121.3 mmHg (P<0.001). Conclusion. Elective cardiac surgery with CPB induced short-term elevation of plasma MMP-9 concentrations within 24 hours, however, without significant correlation with CPB time and postoperative pulmonary dysfunction, despite predominantly increased neutrophils and reduced oxygenation.http://dx.doi.org/10.1155/2015/341740 |
| spellingShingle | Tso-Chou Lin Feng-Yen Lin Yi-Wen Lin Che-Hao Hsu Go-Shine Huang Zhi-Fu Wu Yi-Ting Tsai Chih-Yuan Lin Chi-Yuan Li Chien-Sung Tsai Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery Mediators of Inflammation |
| title | Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery |
| title_full | Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery |
| title_fullStr | Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery |
| title_full_unstemmed | Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery |
| title_short | Matrix Metalloproteinase-9 Production following Cardiopulmonary Bypass Was Not Associated with Pulmonary Dysfunction after Cardiac Surgery |
| title_sort | matrix metalloproteinase 9 production following cardiopulmonary bypass was not associated with pulmonary dysfunction after cardiac surgery |
| url | http://dx.doi.org/10.1155/2015/341740 |
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