High accumulation of linezolid and its major metabolite in the serum of patients with hepatic and renal dysfunction is significantly associated with thrombocytopenia and anemia

High accumulation of linezolid and its major metabolite in the serum of patients with hepatic and renal dysfunction is significantly associated with thrombocytopenia and anemia

ABSTRACT This study aims to examine the serum levels of linezolid and its metabolites (PNU-142300 and PNU-142586) in patients with varying hepatic and renal function. It seeks to understand how these levels relate to thrombocytopenia and anemia and to identify concentration thresholds that could cau...

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Bibliographic Details
Main Authors: Junqiang Gou, Qian Li, Ning Fan, Chen Zhang, Haiwen Tang, Xiaofeng Wang, Dongfeng Yin
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
linezolid
therapeutic drug monitoring
threshold
adverse reactions
relationship analysis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02493-24
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