Polyploid giant cancer cells and tumor budding: translation from basic research to clinical application

Polyploid giant cancer cells and tumor budding: translation from basic research to clinical application

Polyploid giant cancer cells (PGCCs) represent a distinct subpopulation of tumor cells characterized by enlarged or multiple nuclei and aneuploidy. PGCCs are products of genomic instability, possessing cancer stem cell properties and exhibiting significant resistance to radiotherapy and chemotherapy...

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Bibliographic Details
Main Authors:	Peng Huang, Rong Wu, Zhimou Yang, Yuwei Li, Fei Fei, Yongjun Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Oncology
Subjects:	tumor budding metastasis drug resistance therapeutic strategies polyploid giant cancer cells (PGCCs)
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1611920/full
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