A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors
Abstract Pancreatic neuroendocrine tumors (pNETs) are a rare subset of pancreatic cancers often diagnosed late and characterized by complex behaviors. Recent evidence suggests the gut microbiome (GM) significantly influences various diseases by modulating the immune system. This study utilized a Men...
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| Format: | Article |
| Language: | English |
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Springer
2025-05-01
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| Series: | Discover Oncology |
| Online Access: | https://doi.org/10.1007/s12672-025-02761-3 |
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| author | Fangsheng Chen Yuan Zhou Xinwen Mao Ronggui Lin Heguang Huang |
| author_facet | Fangsheng Chen Yuan Zhou Xinwen Mao Ronggui Lin Heguang Huang |
| author_sort | Fangsheng Chen |
| collection | DOAJ |
| description | Abstract Pancreatic neuroendocrine tumors (pNETs) are a rare subset of pancreatic cancers often diagnosed late and characterized by complex behaviors. Recent evidence suggests the gut microbiome (GM) significantly influences various diseases by modulating the immune system. This study utilized a Mendelian randomization (MR) approach to investigate the causal relationship between GM and pNETs, using single nucleotide polymorphism data as instrumental variables. Two-sample MR analysis identified significant correlations between GM and immune cell types. The study found eight specific GMs affecting pNETs risk: the family Sutterellaceae (OR: 1.52, 95% CI 1.10–2.10, p = 0.01), the genus Paraprevotella (OR: 1.34, 95% CI 1.05–1.72, p = 0.02), the species Paraprevotella unclassified (OR: 1.40, 95% CI 1.08–1.81, p = 0.01), and the species Ruminococcus torques (OR: 1.45, 95% CI 1.12–1.89, p = 0.01) increased risk, while the class Gammaproteobacteria (OR: 0.75, 95% CI 0.57–0.98, p = 0.04), the family Acidaminococcaceae (OR: 0.70, 95% CI 0.52–0.94, p = 0.02), the species Paraprevotella xylaniphila (OR: 0.72, 95% CI 0.54–0.96, p = 0.03), and the species Bacteroides finegoldii (OR: 0.68, 95% CI 0.51–0.91, p = 0.01) decreased it. Mediation analysis indicated the species Ruminococcus torques mediated the effect of CD25 on CD45RA+ CD4 non-regulatory T cells on pNETs, accounting for 3.6% of the total effect. This study provides evidence suggestive of a potential causal role of specific GM compositions in pNETs progression and their mediation through immune cell signatures. However, mechanistic studies are required to further validate this relationship. Graphical abstract |
| format | Article |
| id | doaj-art-0b7c3234e9d04d69a64fa2b82356a17d |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-0b7c3234e9d04d69a64fa2b82356a17d2025-08-20T02:00:03ZengSpringerDiscover Oncology2730-60112025-05-0116111010.1007/s12672-025-02761-3A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumorsFangsheng Chen0Yuan Zhou1Xinwen Mao2Ronggui Lin3Heguang Huang4Department of General Surgery, Fujian Medical University Union HospitalDepartment of General Surgery, Fujian Medical University Union HospitalDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityDepartment of General Surgery, Fujian Medical University Union HospitalDepartment of General Surgery, Fujian Medical University Union HospitalAbstract Pancreatic neuroendocrine tumors (pNETs) are a rare subset of pancreatic cancers often diagnosed late and characterized by complex behaviors. Recent evidence suggests the gut microbiome (GM) significantly influences various diseases by modulating the immune system. This study utilized a Mendelian randomization (MR) approach to investigate the causal relationship between GM and pNETs, using single nucleotide polymorphism data as instrumental variables. Two-sample MR analysis identified significant correlations between GM and immune cell types. The study found eight specific GMs affecting pNETs risk: the family Sutterellaceae (OR: 1.52, 95% CI 1.10–2.10, p = 0.01), the genus Paraprevotella (OR: 1.34, 95% CI 1.05–1.72, p = 0.02), the species Paraprevotella unclassified (OR: 1.40, 95% CI 1.08–1.81, p = 0.01), and the species Ruminococcus torques (OR: 1.45, 95% CI 1.12–1.89, p = 0.01) increased risk, while the class Gammaproteobacteria (OR: 0.75, 95% CI 0.57–0.98, p = 0.04), the family Acidaminococcaceae (OR: 0.70, 95% CI 0.52–0.94, p = 0.02), the species Paraprevotella xylaniphila (OR: 0.72, 95% CI 0.54–0.96, p = 0.03), and the species Bacteroides finegoldii (OR: 0.68, 95% CI 0.51–0.91, p = 0.01) decreased it. Mediation analysis indicated the species Ruminococcus torques mediated the effect of CD25 on CD45RA+ CD4 non-regulatory T cells on pNETs, accounting for 3.6% of the total effect. This study provides evidence suggestive of a potential causal role of specific GM compositions in pNETs progression and their mediation through immune cell signatures. However, mechanistic studies are required to further validate this relationship. Graphical abstracthttps://doi.org/10.1007/s12672-025-02761-3 |
| spellingShingle | Fangsheng Chen Yuan Zhou Xinwen Mao Ronggui Lin Heguang Huang A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors Discover Oncology |
| title | A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors |
| title_full | A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors |
| title_fullStr | A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors |
| title_full_unstemmed | A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors |
| title_short | A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors |
| title_sort | systematic mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors |
| url | https://doi.org/10.1007/s12672-025-02761-3 |
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