Innovations, challenges, and minimal information for standardization of humanized mice

Innovations, challenges, and minimal information for standardization of humanized mice

Abstract Mice xenotransplanted with human cells and/or expressing human gene products (also known as “humanized mice”) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant in vivo context for understanding of human‐s...

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Main Authors: Renata Stripecke, Christian Münz, Jan Jacob Schuringa, Karl‐Dimiter Bissig, Brian Soper, Terrence Meeham, Li‐Chin Yao, James P Di Santo, Michael Brehm, Estefania Rodriguez, Anja Kathrin Wege, Dominique Bonnet, Silvia Guionaud, Kristina E Howard, Scott Kitchen, Florian Klein, Kourosh Saeb‐Parsy, Johannes Sam, Amar Deep Sharma, Andreas Trumpp, Livio Trusolino, Carol Bult, Leonard Shultz
Format: Article
Language:English
Published: Springer Nature 2020-06-01
Series:EMBO Molecular Medicine
Subjects:
humanized mice
infections
PDX
immuno‐oncology
regenerative medicine
Online Access:https://doi.org/10.15252/emmm.201708662
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