Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer
Abstract Recent studies have progressively clarified the critical role of long non-coding RNA (lncRNA) in cancer, especially concerning its involvement in immune processes, which holds significant therapeutic promise. However, the incorporation of lncRNA into immunotherapy has yet to demonstrate ade...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06732-8 |
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| author | Dechun Zhang Shaoxuan Pei Zixuan Feng Guangfeng Xia |
| author_facet | Dechun Zhang Shaoxuan Pei Zixuan Feng Guangfeng Xia |
| author_sort | Dechun Zhang |
| collection | DOAJ |
| description | Abstract Recent studies have progressively clarified the critical role of long non-coding RNA (lncRNA) in cancer, especially concerning its involvement in immune processes, which holds significant therapeutic promise. However, the incorporation of lncRNA into immunotherapy has yet to demonstrate adequate clinical efficacy. This shortcoming can be attributed to various challenges, including unclear mechanisms of action and limited prognostic capacity. In colorectal cancer (CRC), this ineffectiveness may predominantly stem from immune escape mechanisms mediated by lncRNAs. Despite some exploration into lncRNA-driven immune escape, a comprehensive overview of its implications for immunotherapy in CRC remains inadequately addressed. In this review, we thoroughly assess the role of lncRNA in immune escape mechanisms associated with CRC, focusing on immune checkpoints, immune cells, and cytokines. We elucidate the relationship between lncRNA-mediated immune escape and CRC progression and discuss strategies for lncRNA-mediated immunotherapy for CRC. Our aim is to provide fresh insights into the potential of targeting lncRNAs to enhance the effectiveness of immunotherapeutic strategies in CRC. |
| format | Article |
| id | doaj-art-0b7922c5538e4ea598e9e0e10eb11003 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-0b7922c5538e4ea598e9e0e10eb110032025-08-20T03:47:16ZengBMCJournal of Translational Medicine1479-58762025-06-0123112110.1186/s12967-025-06732-8Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancerDechun Zhang0Shaoxuan Pei1Zixuan Feng2Guangfeng Xia3Queen Mary School, Jiangxi Medical College, Nanchang UniversityQueen Mary School, Jiangxi Medical College, Nanchang UniversityQueen Mary School, Jiangxi Medical College, Nanchang UniversityDepartment of Hepatobiliary Surgery, Jiujiang University Affiliated HospitalAbstract Recent studies have progressively clarified the critical role of long non-coding RNA (lncRNA) in cancer, especially concerning its involvement in immune processes, which holds significant therapeutic promise. However, the incorporation of lncRNA into immunotherapy has yet to demonstrate adequate clinical efficacy. This shortcoming can be attributed to various challenges, including unclear mechanisms of action and limited prognostic capacity. In colorectal cancer (CRC), this ineffectiveness may predominantly stem from immune escape mechanisms mediated by lncRNAs. Despite some exploration into lncRNA-driven immune escape, a comprehensive overview of its implications for immunotherapy in CRC remains inadequately addressed. In this review, we thoroughly assess the role of lncRNA in immune escape mechanisms associated with CRC, focusing on immune checkpoints, immune cells, and cytokines. We elucidate the relationship between lncRNA-mediated immune escape and CRC progression and discuss strategies for lncRNA-mediated immunotherapy for CRC. Our aim is to provide fresh insights into the potential of targeting lncRNAs to enhance the effectiveness of immunotherapeutic strategies in CRC.https://doi.org/10.1186/s12967-025-06732-8Long non-coding RNAColorectal cancerImmune escapeImmunotherapy |
| spellingShingle | Dechun Zhang Shaoxuan Pei Zixuan Feng Guangfeng Xia Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer Journal of Translational Medicine Long non-coding RNA Colorectal cancer Immune escape Immunotherapy |
| title | Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer |
| title_full | Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer |
| title_fullStr | Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer |
| title_full_unstemmed | Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer |
| title_short | Functions and mechanisms of lncRNAs in immune escape and their application in immunotherapy for colorectal cancer |
| title_sort | functions and mechanisms of lncrnas in immune escape and their application in immunotherapy for colorectal cancer |
| topic | Long non-coding RNA Colorectal cancer Immune escape Immunotherapy |
| url | https://doi.org/10.1186/s12967-025-06732-8 |
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