The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand?
Injectable Platelet-Rich Fibrin (i-PRF) has emerged as a promising tool in regenerative medicine, particularly in orthopedics, due to its unique biological properties and ease of preparation. i-PRF is an autologous platelet concentrate derived through a simple, anticoagulant-free centrifugation proc...
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MDPI AG
2025-03-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/4/239 |
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| author | Fábio Ramos Costa Sergio Augusto Lopes de Souza Rubens Andrade Martins Bruno Ramos Costa Luyddy Pires Alex Pontes de Macedo Napoliane Santos Stephany Cares Huber Gabriel Silva Santos André Kruel Márcia Santos José Fábio Lana |
| author_facet | Fábio Ramos Costa Sergio Augusto Lopes de Souza Rubens Andrade Martins Bruno Ramos Costa Luyddy Pires Alex Pontes de Macedo Napoliane Santos Stephany Cares Huber Gabriel Silva Santos André Kruel Márcia Santos José Fábio Lana |
| author_sort | Fábio Ramos Costa |
| collection | DOAJ |
| description | Injectable Platelet-Rich Fibrin (i-PRF) has emerged as a promising tool in regenerative medicine, particularly in orthopedics, due to its unique biological properties and ease of preparation. i-PRF is an autologous platelet concentrate derived through a simple, anticoagulant-free centrifugation process, resulting in a liquid matrix enriched with fibrin, leukocytes, and growth factors. These components promote tissue regeneration, angiogenesis, and anti-inflammatory responses, making i-PRF suitable for bone and cartilage repair as well as drug delivery systems. This review discusses the history, biological mechanisms, and clinical applications of i-PRF in orthopedics, highlighting its potential advantages over traditional platelet-rich plasma (PRP). Furthermore, we address the challenges and limitations of i-PRF, including drug stability, release control, and bioactive interactions, underscoring the need for further research to optimize its therapeutic efficacy. |
| format | Article |
| id | doaj-art-0b75b2d62ad443ce98ae43d2dc3bbc39 |
| institution | DOAJ |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-0b75b2d62ad443ce98ae43d2dc3bbc392025-08-20T03:13:49ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-03-0147423910.3390/cimb47040239The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand?Fábio Ramos Costa0Sergio Augusto Lopes de Souza1Rubens Andrade Martins2Bruno Ramos Costa3Luyddy Pires4Alex Pontes de Macedo5Napoliane Santos6Stephany Cares Huber7Gabriel Silva Santos8André Kruel9Márcia Santos10José Fábio Lana11Department of Orthopedics, FC Sports Traumatology, Salvador 40296-210, BA, BrazilDepartment of Radiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-916, RJ, BrazilMedical School, Tiradentes University Center, Maceió 57038-000, AL, BrazilMedical School, Zarns College, Salvador 41720-200, BA, BrazilDepartment of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, BrazilDepartment of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, BrazilDepartment of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, BrazilDepartment of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, BrazilDepartment of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, BrazilRegenerative Medicine, Orthoregen International Course, Indaiatuba 13334-170, SP, BrazilNutritional Sciences, Metropolitan Union of Education and Culture, Salvador 42700-000, BA, BrazilDepartment of Orthopedics, Brazilian Institute of Regenerative Medicine (BIRM), Indaiatuba 13334-170, SP, BrazilInjectable Platelet-Rich Fibrin (i-PRF) has emerged as a promising tool in regenerative medicine, particularly in orthopedics, due to its unique biological properties and ease of preparation. i-PRF is an autologous platelet concentrate derived through a simple, anticoagulant-free centrifugation process, resulting in a liquid matrix enriched with fibrin, leukocytes, and growth factors. These components promote tissue regeneration, angiogenesis, and anti-inflammatory responses, making i-PRF suitable for bone and cartilage repair as well as drug delivery systems. This review discusses the history, biological mechanisms, and clinical applications of i-PRF in orthopedics, highlighting its potential advantages over traditional platelet-rich plasma (PRP). Furthermore, we address the challenges and limitations of i-PRF, including drug stability, release control, and bioactive interactions, underscoring the need for further research to optimize its therapeutic efficacy.https://www.mdpi.com/1467-3045/47/4/239platelet-rich fibrinorthopedicstissue regenerationanti-inflammatory therapyregenerative medicine |
| spellingShingle | Fábio Ramos Costa Sergio Augusto Lopes de Souza Rubens Andrade Martins Bruno Ramos Costa Luyddy Pires Alex Pontes de Macedo Napoliane Santos Stephany Cares Huber Gabriel Silva Santos André Kruel Márcia Santos José Fábio Lana The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand? Current Issues in Molecular Biology platelet-rich fibrin orthopedics tissue regeneration anti-inflammatory therapy regenerative medicine |
| title | The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand? |
| title_full | The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand? |
| title_fullStr | The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand? |
| title_full_unstemmed | The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand? |
| title_short | The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand? |
| title_sort | role of injectable platelet rich fibrin in orthopedics where do we stand |
| topic | platelet-rich fibrin orthopedics tissue regeneration anti-inflammatory therapy regenerative medicine |
| url | https://www.mdpi.com/1467-3045/47/4/239 |
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