Levels of IL-6 and IL-1β in Umbilical Cord Blood in Relation to Mode of Birth
OBJECTIVE: The present study aims to determine whether normal spontaneous vaginal delivery at term was associated with an inflammatory activation compared with scheduled cesarean section without previous onset of labor by detecting cord blood serum levels of interleukin-6 (IL-6) and interleukin-1β...
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Medical Network
2014-04-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/121 |
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| author | Ebru Aslan Patlakoğlu Sündüz Özlem ALTINKAYA Mustafa Uğur Cuma Taşın Nezaket Kadıoğlu |
| author_facet | Ebru Aslan Patlakoğlu Sündüz Özlem ALTINKAYA Mustafa Uğur Cuma Taşın Nezaket Kadıoğlu |
| author_sort | Ebru Aslan Patlakoğlu |
| collection | DOAJ |
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OBJECTIVE: The present study aims to determine whether normal spontaneous vaginal delivery at term was associated with an inflammatory activation compared with scheduled cesarean section without previous onset of labor by detecting cord blood serum levels of interleukin-6 (IL-6) and interleukin-1β (IL-1β).
STUDY DESIGN: Eighty-eight patients were studied (vaginal delivery n=44 and scheduled cesarean n=44) with cord venous blood sampling after delivery of the fetus. IL-6 and IL-1β levels were measured with commercial kits. All of the subjects had uncomplicated term singleton pregnancies.
RESULTS: Both study groups showed no significant difference in maternal age, gestational week, birth weight, body mass index (p>0.05). Cord blood IL-6 and IL-1β levels were similar between spontaneous vaginal delivery and scheduled cesarean groups (3.1±2.0 pg/mL versus 3.1±2.9 pg/mL, p=0.62 and 2.0±1.7 pg/mL versus 2.3±1.8 pg/mL, p=0.46, respectively). Also maternal age, gestational week, birth weight and body mass index did not correlate with cord blood cytokine levels.
CONCLUSION: In healthy and term pregnancies, the exposition of spontaneous vaginal delivery and labor is not associated with activation of inflammatory mediators compared to cesarean. The data of the present study did not support the increasing ratio of newborn complications (respiratory distress syndrome, bronchopulmonary dysplasia, the need for prolonged oxygen therapy and neonatal intensive care unit, allergic diseases of infancy period) after cesarean delivery due to inadequate increasing levels of cytokines in newborns delivered by cesarean.
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| format | Article |
| id | doaj-art-0b73e99523604ec8b661148add04c010 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2014-04-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-0b73e99523604ec8b661148add04c0102025-02-11T21:23:14ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182014-04-0120163Levels of IL-6 and IL-1β in Umbilical Cord Blood in Relation to Mode of BirthEbru Aslan Patlakoğlu0Sündüz Özlem ALTINKAYA1Mustafa Uğur2Cuma Taşın3Nezaket Kadıoğlu4Dumlupınar University Kütahya Evliya Çelebi Education and Research Hospital, KütahyaAdnan Menderes University Faculty of Medicine, AydınZekai Tahir Burak Women's Health Education and Research Hospital, AnkaraZekai Tahir Burak Women's Health Education and Research Hospital, AnkaraZekai Tahir Burak Women's Health Education and Research Hospital, Ankara OBJECTIVE: The present study aims to determine whether normal spontaneous vaginal delivery at term was associated with an inflammatory activation compared with scheduled cesarean section without previous onset of labor by detecting cord blood serum levels of interleukin-6 (IL-6) and interleukin-1β (IL-1β). STUDY DESIGN: Eighty-eight patients were studied (vaginal delivery n=44 and scheduled cesarean n=44) with cord venous blood sampling after delivery of the fetus. IL-6 and IL-1β levels were measured with commercial kits. All of the subjects had uncomplicated term singleton pregnancies. RESULTS: Both study groups showed no significant difference in maternal age, gestational week, birth weight, body mass index (p>0.05). Cord blood IL-6 and IL-1β levels were similar between spontaneous vaginal delivery and scheduled cesarean groups (3.1±2.0 pg/mL versus 3.1±2.9 pg/mL, p=0.62 and 2.0±1.7 pg/mL versus 2.3±1.8 pg/mL, p=0.46, respectively). Also maternal age, gestational week, birth weight and body mass index did not correlate with cord blood cytokine levels. CONCLUSION: In healthy and term pregnancies, the exposition of spontaneous vaginal delivery and labor is not associated with activation of inflammatory mediators compared to cesarean. The data of the present study did not support the increasing ratio of newborn complications (respiratory distress syndrome, bronchopulmonary dysplasia, the need for prolonged oxygen therapy and neonatal intensive care unit, allergic diseases of infancy period) after cesarean delivery due to inadequate increasing levels of cytokines in newborns delivered by cesarean. https://gorm.com.tr/index.php/GORM/article/view/121CytokinesMode of birthCord bloodInflammation |
| spellingShingle | Ebru Aslan Patlakoğlu Sündüz Özlem ALTINKAYA Mustafa Uğur Cuma Taşın Nezaket Kadıoğlu Levels of IL-6 and IL-1β in Umbilical Cord Blood in Relation to Mode of Birth Gynecology Obstetrics & Reproductive Medicine Cytokines Mode of birth Cord blood Inflammation |
| title | Levels of IL-6 and IL-1β in Umbilical Cord Blood in Relation to Mode of Birth |
| title_full | Levels of IL-6 and IL-1β in Umbilical Cord Blood in Relation to Mode of Birth |
| title_fullStr | Levels of IL-6 and IL-1β in Umbilical Cord Blood in Relation to Mode of Birth |
| title_full_unstemmed | Levels of IL-6 and IL-1β in Umbilical Cord Blood in Relation to Mode of Birth |
| title_short | Levels of IL-6 and IL-1β in Umbilical Cord Blood in Relation to Mode of Birth |
| title_sort | levels of il 6 and il 1β in umbilical cord blood in relation to mode of birth |
| topic | Cytokines Mode of birth Cord blood Inflammation |
| url | https://gorm.com.tr/index.php/GORM/article/view/121 |
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